Novel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies

Autor: Christie Mitri, Zhengzhong Xu, Pauline Bardin, Harriet Corvol, Lhousseine Touqui, Olivier Tabary

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Cystic fibrosis (CF) is the most common genetic disorder among Caucasians, estimated to affect more than 70,000 people in the world. Severe and persistent bronchial inflammation and chronic bacterial infection, along with airway mucus obstruction, ar

Externí odkaz: https://doaj.org/article/8b5f978c7d3a4c3cb3025ba2c69b94ab

Emerging microRNA Therapeutic Approaches for Cystic Fibrosis

Autor: Pauline Bardin, Florence Sonneville, Harriet Corvol, Olivier Tabary

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs. The absence of this channel results in an imbalance

Externí odkaz: https://doaj.org/article/6a233c8e33a149c79ae8619d09fd836e

Small RNA and transcriptome sequencing reveal the role of miR-199a-3p in inflammatory processes in cystic fibrosis airways: miR-199a-3p regulates the NF-κB pathway in the lungs of CF patients

Autor: Pauline, Bardin, Emmeline, Marchal-Duval, Florence, Sonneville, Sabine, Blouquit-Laye, Nathalie, Rousselet, Philippe, Le Rouzic, Harriet, Corvol, Olivier, Tabary

Publikováno v: The Journal of pathology and bacteriology
The Journal of pathology and bacteriology, John Wiley & Sons, 2018, 245 (4), pp.410-420. ⟨10.1002/path.5095⟩

International audience; Cystic fibrosis (CF) is the most common lethal genetic disease, caused by CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations. CF is characterized by an ionic imbalance and thickened mucus, which impair m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f906c6f3a0ccd6cf360edc36c538067d
https://www.hal.inserm.fr/inserm-02390385

Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells.

Autor: Cyr-Depauw, Chanèle, Cook, David P., Mižik, Ivana, Lesage, Flore, Vadivel, Arul, Renesme, Laurent, Deng, Yupu, Zhong, Shumei, Bardin, Pauline, Xu, Liqun, Möbius, Marius A., Marzahn, Jenny, Freund, Daniel, Stewart, Duncan J., Vanderhyden, Barbara C., Rüdiger, Mario, Thébaud, Bernard

Publikováno v: American Journal of Respiratory & Critical Care Medicine; 9/15/2024, Vol. 210 Issue 6, p814-827, 14p

Single-Cell RNA Sequencing-Based Characterization of Resident Lung Mesenchymal Stromal Cells in Bronchopulmonary Dysplasia.

Autor: Mižíková, Ivana, Lesage, Flore, Cyr-Depauw, Chanele, Cook, David P, Hurskainen, Maria, Hänninen, Satu M, Vadivel, Arul, Bardin, Pauline, Zhong, Shumei, Carpén, Olli, Vanderhyden, Barbara C, Thébaud, Bernard

Publikováno v: Stem Cells; May2022, Vol. 40 Issue 5, p479-492, 14p