Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Paulina Will"'
Autor:
Jasim Kada Benotmane, Jan Kueckelhaus, Paulina Will, Junyi Zhang, Vidhya M. Ravi, Kevin Joseph, Roman Sankowski, Jürgen Beck, Catalina Lee-Chang, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated immune dysfunction. Current spatially resolved transcriptomic technologies are unable to directly annotate T cell receptors (TCR). We present spatiall
Externí odkaz:
https://doaj.org/article/3bbd27aa3be14c8cb9783f3bdb460db0
Autor:
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Jürgen Beck, Henrike Salié, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The tumour microenvironment counteracts immune therapy in Glioblastomas. Authors show here, using spatially resolved and single cell transcriptomics, that dysfunctional T cells are induced by a myeloid cell subset via Interleukin-10 signalling, and i
Externí odkaz:
https://doaj.org/article/c8ede93aa6744a97b9b18e93349c871a
Autor:
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance dur
Externí odkaz:
https://doaj.org/article/b89ed836d7234b6e8298f323cfead154
Autor:
Alexander Grote, Dieter-Henrik Heiland, Julia Taube, Christoph Helmstaedter, Vidhya M Ravi, Paulina Will, Elke Hattingen, Jan-Rüdiger Schüre, Juri-Alexander Witt, Annika Reimers, Christian Elger, Johannes Schramm, Albert J Becker, Daniel Delev
Publikováno v:
Brain : a journal of neurology 146(2), 549-560 (2023). doi:10.1093/brain/awac293
Brain : a journal of neurology 146(2), 549-560 (2023). doi:10.1093/brain/awac293
Published by Oxford Univ. Press, Oxford
Published by Oxford Univ. Press, Oxford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1237a4ad3ae3fd75ce78f8d9bda213a3
Autor:
Simon P Behringer, Vidhya M Ravi, Oliver Schnell, Jasim Kada Benotmane, Henrike Salié, Marie Follo, Daniel Delev, Marius Schwabenland, Ulrich G. Hofmann, Melanie Boerries, Jonathan M Goeldner, Mohammed Khiat, Christian Fung, Manching Ku, Axel Walch, Jürgen Beck, Dieter Henrik Heiland, Ugne Kuliesiute, Florian Scherer, Ulrich Schüller, Paulina Will, Lea Vollmer, Na Sun, Pamela Franco, Roman Sankowski, Jasmin von Ehr, Kevin Joseph, Marco Prinz, Katrin Lamszus, Franz Ricklefs, Junyi Zhang, Jan Kueckelhaus, Saskia Killmer, Nicolas Neidert, Bertram Bengsch
Publikováno v:
Cancer cell, Cambridge, MA : Cell Press, 2022, vol. 40, iss. 6, p. 639-655, e1-e13
Cancer Cell 40, 639-655.e13 (2022)
Cancer Cell 40, 639-655.e13 (2022)
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of the dynamic reorganization within the spatial context of these tumors remains elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e8ee4dd63c97972bea35b3546493e
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
Autor:
Franz Ricklefs, Oliver Schnell, Vidyha Ravi, Dieter Henrik Heiland, Jürgen Beck, Kevin Joseph, Jan Kückelhaus, Jasim Kada Benotmane, Paulina Will
Publikováno v:
Neuro Oncol
High-dimensional technologies have provided insights into transcriptional heterogeneity and dynamic plasticity which are hallmarks of brain tumors. Although scRNA-seq recovers the diversity of transcriptional states, their spatial context within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944f552c8554f40d35af2a2020dd5dce
https://europepmc.org/articles/PMC8598897/
https://europepmc.org/articles/PMC8598897/
Autor:
Vidhya Ravi, Simon Behringer, Kevin Joseph, Luciana Haniball, Jan Kueckelhaus, Paulina Will, Nicolas Neidert, Jonathan Goeldner, Pamela Franco, Christian Fung, Juergen Beck, Roman Sankowski, Marco Prinz, Ulrich Hofmann, Oliver Schnell, Dieter Henrik Heiland
Reactive transformation of astrocytes in IDH wild-type glioma contribute to anti-tumor immunity and support pro-oncogenic signaling. The role of intra- and peritumoral astrocytes in IDH1/2 mutated glioma, a prognostically beneficial subgroup with onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b561a91818892df99104a4a78f748bfa
https://doi.org/10.21203/rs.3.rs-720962/v1
https://doi.org/10.21203/rs.3.rs-720962/v1
Autor:
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salié, Jasmin von Ehr, Lea Vollmer, Jasim K. Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M Goeldner, Simon P. Behringer, Pamela Franco, Ulrich G. Hofmann, Christian Fung, Jürgen Beck, Roman Sankowski, Marco Prinz, Saskia Killmer, Bertram Bengsch, Axel Karl Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c363038a378ba4957da7d5adc0078b
https://doi.org/10.1101/2021.02.16.431475
https://doi.org/10.1101/2021.02.16.431475
Autor:
Florian Scherer, Jonathan M Goeldner, Dieter Henrik Heiland, Julius M Kernbach, Tobias Weiss, Marco Prinz, Kevin Joseph, Pamela Franco, Roman Sankowski, Jan Kückelhaus, Christine Dierks, Maria Stella Carro, Julian P Maier, Nicolas Neidert, Melanie Boerries, Marie Follo, Ulrich G. Hofmann, Simon P Behringer, Paulina Will, Nils Schallner, Vidhya M Ravi, Daniel Delev, Christian Fung, Jürgen Beck, Lea Vollmer, Oliver Schnell
Despite recent advances in cancer immunotherapy, its efficacy in Glioblastoma (GBM) is limited due to poor understanding of molecular states and cellular plasticity of immune cells within the tumor microenvironment. Here, we combined spatial and sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb2383ea71d810fc6a5f797e3076c1e
https://doi.org/10.21203/rs.3.rs-244157/v1
https://doi.org/10.21203/rs.3.rs-244157/v1
Autor:
Roman Sankowski, Saskia Killmer, Kevin Joseph, Henrike Salié, Jonathan M Goeldner, Vidhya M Ravi, Marie Follo, Nicolas Neidert, Na Sun, Ulrich G. Hofmann, Florian Scherer, Simon P Behringer, Jasim Kada Benotmane, Jan Kekelhaus, Daniel Delev, Oliver Schnell, Lea Vollmer, Christian Fung, Jürgen Beck, Dieter Henrik Heiland, Paulina Will, Bertram Bengsch, Marco Prinz, Pamela Franco, Jasmin von Ehr, Axel Walch
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4874e0d1d05588b27fb7dddf6d13147d
https://doi.org/10.21203/rs.3.rs-244902/v1
https://doi.org/10.21203/rs.3.rs-244902/v1