Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Paulina Valenzuela-Hormazabal"'
Autor:
Paulina Valenzuela-Hormazabal, Romina V. Sepúlveda, Melissa Alegría-Arcos, Elizabeth Valdés-Muñoz, Víctor Rojas-Pérez, Ileana González-Bonet, Reynier Suardíaz, Christian Galarza, Natalia Morales, Verónica Leddermann, Ricardo I. Castro, Bruna Benso, Gabriela Urra, Erix W. Hernández-Rodríguez, Daniel Bustos
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 1968 (2024)
Helicobacter pylori (Hp) infections pose a global health challenge demanding innovative therapeutic strategies by which to eradicate them. Urease, a key Hp virulence factor hydrolyzes urea, facilitating bacterial survival in the acidic gastric enviro
Externí odkaz:
https://doaj.org/article/7e05afd178a648809ebbfdbdf94badcf
Autor:
Maximiliano Martínez-Cifuentes, Emmanuel Soto-Tapia, Camila Linares-Pipón, Ben Bradshaw, Paulina Valenzuela-Hormazabal, David Ramírez, Patricio Muñoz-Torres, Claudio Parra
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1339 (2023)
This work proposes the design of β-keto esters as antibacterial compounds. The design was based on the structure of the autoinducer of bacterial quorum sensing, N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). Eight β-keto ester analogues we
Externí odkaz:
https://doaj.org/article/3a8fe336900a4e60ac4efa03d5c88dac
Autor:
Matías Monroy-Cárdenas, Cristopher Almarza, Paulina Valenzuela-Hormazábal, David Ramírez, Félix A. Urra, Maximiliano Martínez-Cifuentes, Ramiro Araya-Maturana
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8334 (2024)
α-glucosidase, a pharmacological target for type 2 diabetes mellitus (T2DM), is present in the intestinal brush border membrane and catalyzes the hydrolysis of sugar linkages during carbohydrate digestion. Since α-glucosidase inhibitors (AGIs) modu
Externí odkaz:
https://doaj.org/article/ea3865e24dd84c8599b81ce082bb238d
Autor:
Natalia Morales, Elizabeth Valdés-Muñoz, Jaime González, Paulina Valenzuela-Hormazábal, Jonathan M. Palma, Christian Galarza, Ángel Catagua-González, Osvaldo Yáñez, Alfredo Pereira, Daniel Bustos
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4303 (2024)
Urease, a pivotal enzyme in nitrogen metabolism, plays a crucial role in various microorganisms, including the pathogenic Helicobacter pylori. Inhibiting urease activity offers a promising approach to combating infections and associated ailments, suc
Externí odkaz:
https://doaj.org/article/50ee0f61f92b460b8e9d837620c86b19