Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease

Autor: Kevin Blanco, Stefanny Salcidua, Paulina Orellana, Tania Sauma-Pérez, Tomás León, Lorena Cecilia López Steinmetz, Agustín Ibañez, Claudia Duran-Aniotz, Rolando de la Cruz

Publikováno v: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2023)

Abstract Mild cognitive impairment (MCI) is often considered an early stage of dementia, with estimated rates of progression to dementia up to 80–90% after approximately 6 years from the initial diagnosis. Diagnosis of cognitive impairment in demen

Externí odkaz: https://doaj.org/article/0a2e8de3929c4c25a49843bfc3b03be6

Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries

Autor: Claudia Duran-Aniotz, Paulina Orellana, Tomas Leon Rodriguez, Fernando Henriquez, Victoria Cabello, María F. Aguirre-Pinto, Tamara Escobedo, Leonel T. Takada, Stefanie D. Pina-Escudero, Oscar Lopez, Jennifer S. Yokoyama, Agustin Ibanez, Mario A. Parra, Andrea Slachevsky

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Frontotemporal dementia (FTD) includes a group of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders, affecting the fronto-insular-temporal regions of the brain. Clinically, FTD is characterized by progressive defic

Externí odkaz: https://doaj.org/article/8eff1edc95a64035ba74af1ffa80104b

Observations from a nationwide vigilance program in medical care for spinal muscular atrophy patients in Chile

Autor: Karin ALVAREZ, Bernardita SUAREZ, María Angélica PALOMINO, Cecilia HERVIAS, Giancarlo CALCAGNO, Maripaz MARTÍNEZ-JALILIE, Andrés LOZANO-ARANGO, Susana LILLO, Mariana HARO, Fanny CORTÉS, Samuel PANTOJA, Andrés CHAHIN, Paulina ORELLANA, Jorge A BEVILACQUA, Enrico BERTINI, Claudia CASTIGLIONI

Publikováno v: Arquivos de Neuro-Psiquiatria, Vol 77, Iss 7, Pp 470-477

ABSTRACT Spinal muscular atrophy (SMA) has gained much attention in the last few years because of the approval of the first intrathecal treatment for this neurodegenerative disease. Latin America needs to develop the demographics of SMA, timely acces

Externí odkaz: https://doaj.org/article/c1d9e5aeaf8648dd84b111b702c69fe6

Biomarkers for dementia in Latin American countries:Gaps and opportunities

Autor: Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibañez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Piña‐Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias‐Suárez, Bernardo Barra, Maria Isabel Behrens, Sonia M. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro‐Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz‐Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farías, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nuñez, Santiago O'Neill, John Ochoa, Maritza Pintado‐Caipa, Elisa de Paula França Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho‐Pilalumbo, Claudia Duran‐Aniotz

Publikováno v: Parra, M A, Orellana, P, Leon, T, Victoria, C G, Henriquez, F, Gomez, R, Avalos, C, Damian, A, Slachevsky, A, Ibañez, A, Zetterberg, H, Tijms, B M, Yokoyama, J S, Piña-Escudero, S D, Cochran, J N, Matallana, D L, Acosta, D, Allegri, R, Arias-Suárez, B P, Barra, B, Behrens, M I, Brucki, S M D, Busatto, G, Caramelli, P, Castro-Suarez, S, Contreras, V, Custodio, N, Dansilio, S, la Cruz-Puebla, M D, de Souza, L C, Diaz, M M, Duque, L, Farías, G A, Ferreira, S T, Guimet, N M, Kmaid, A, Lira, D, Lopera, F, Meza, B M, Miotto, E C, Nitrini, R, Nuñez, A, O'Neill, S, Ochoa, J, Pintado-Caipa, M, Resende, E D P F, Risacher, S, Rojas, L A, Sabaj, V, Schilling, L, Sellek, A F, Sosa, A, Takada, L T, Teixeira, A L, Unaucho-Pilalumbo, M & Duran-Aniotz, C 2022, ' Biomarkers for dementia in Latin American countries : Gaps and opportunities ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12757
Alzheimer's and Dementia. Elsevier

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3eb6423963b88f563b7d3d9628574a
https://research.vumc.nl/en/publications/b1a9b969-eed2-4817-8ede-1f679e06576a

GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly

Autor: Patricia Lillo, Teresa Parrao, Rodrigo Rivera, David Martínez-Pernía, Pedro Zitko, Andrea Slachevsky, Paulina Orellana, Gonzalo Forno, Felipe A. Court, Helena Amieva, Roque Villagra, Daniela Thumala, Carolina Toledo, Christian Christian González-Billault, Mario A. Parra, Rodrigo Assar, Agustín Ibáñez, Claudia Duran-Aniotz

Publikováno v: BMC Geriatrics
BMC Geriatrics, BioMed Central, 2020, 20 (1), pp.505. ⟨10.1186/s12877-020-01866-4⟩

BackgroundWith the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc8f2ca2b363b63df89fda836eea1b1
https://pubmed.ncbi.nlm.nih.gov/33238908