Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Paulina Mierzejewska"'
Autor:
Paulina Mierzejewska, Noemi Di Marzo, Magdalena A. Zabielska-Kaczorowska, Iga Walczak, Ewa M. Slominska, Marialuisa Lavitrano, Roberto Giovannoni, Barbara Kutryb-Zajac, Ryszard T. Smolenski
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1409 (2023)
The vascular endothelium is key target for immune and thrombotic responses that has to be controlled in successful xenotransplantation. Several genes were identified that, if induced or overexpressed, help to regulate the inflammatory response and pr
Externí odkaz:
https://doaj.org/article/1aac718b525641dba818c8e7147fa536
Autor:
Marta Tomczyk, Alicja Braczko, Paulina Mierzejewska, Magdalena Podlacha, Oliwia Krol, Patrycja Jablonska, Agata Jedrzejewska, Karolina Pierzynowska, Grzegorz Wegrzyn, Ewa M. Slominska, Ryszard T. Smolenski
Publikováno v:
Cells, Vol 11, Iss 17, p 2662 (2022)
Huntington’s disease (HD) is a rare neurodegenerative disease that is accompanied by skeletal muscle atrophy and cardiomyopathy. Tissues affected by HD (central nervous system [CNS], skeletal muscle, and heart) are known to suffer from deteriorated
Externí odkaz:
https://doaj.org/article/4c55924b31554778a965e3a4c4a6a0a5
Autor:
Patrycja Jablonska, Paulina Mierzejewska, Marta Tomczyk, Patrycja Koszalka, Marika Franczak, Ada Kawecka, Barbara Kutryb-Zajac, Alicja Braczko, Ryszard T. Smolenski, Ewa M. Slominska
Publikováno v:
Biology, Vol 11, Iss 5, p 675 (2022)
The disruption of the metabolism of extracellular NAD+ and NMN may affect related signaling cascades and pathologies, such as cardiovascular or respiratory system diseases. We aimed to study NAD+ and NMN hydrolysis on surface endothelial cells of div
Externí odkaz:
https://doaj.org/article/57b5eb8fb0a64c7ba25decd71c3be461
Publikováno v:
Molecules, Vol 25, Iss 20, p 4652 (2020)
Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2′deoxyadenosine to 2′deoxyinosine. ADA is active both inside the cell and on the cell surface where it was found to interact with memb
Externí odkaz:
https://doaj.org/article/7ace6ad27ea242b29fb7ba8cc00cdf48
Autor:
Worood A. El-Mehalmey, Najma Latif, Ahmed H. Ibrahim, Rana R. Haikal, Paulina Mierzejewska, Ryszard T. Smolenski, Magdi H. Yacoub, Mohamed H. Alkordi
Publikováno v:
Biomaterials Science. 10:1342-1351
Adenosine is a small molecule directly involved in maintaining homeostasis under pathological and stressful conditions. Due to its rapid metabolism, delivery vehicles capable of exhibiting extended release of adenosine are of paramount interest. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2293bdab1b1c9c37786a6ed8cb3e92d6
https://doi.org/10.1039/d1bm01519b
https://doi.org/10.1039/d1bm01519b
Autor:
Michał Kunc, Pawel Romaszko, Barbara Kutryb-Zajac, Paulina Mierzejewska, Ryszard T. Smolenski, Iwona Pelikant-Malecka, Patrycja Koszałka, Magdalena Zabielska-Kaczorowska, Alicja Braczko, Ewa M. Slominska, Patrycja Jablonska, Jolanta Szade
Publikováno v:
Experimental & Molecular Medicine
Our recent studies identified a novel pathway of nicotinamide metabolism that involves 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) and demonstrated its endothelial cytotoxic effect. This study tested the effects of 4PYR and its metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb881f96b49f70a944c236df03b13328
https://doi.org/10.1038/s12276-021-00669-w
https://doi.org/10.1038/s12276-021-00669-w
Autor:
Alicja Braczko, Barbara Kutryb-Zajac, Agata Jedrzejewska, Oliwia Krol, Paulina Mierzejewska, Magdalena Zabielska-Kaczorowska, Ewa M. Slominska, Ryszard T. Smolenski
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11488
Dyslipidemia triggers many severe pathologies, including atherosclerosis and chronic inflammation. Several lines of evidence, including our studies, have suggested direct effects of dyslipidemia on cardiac energy metabolism, but details of these effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26873e9a09a3fcbba0a37051e08eda1a
https://pubmed.ncbi.nlm.nih.gov/36232794
https://pubmed.ncbi.nlm.nih.gov/36232794
Publikováno v:
Hormones (Athens, Greece)
Purpose Estrogens have beneficial effects on the cardiovascular system, promoting vasodilation, endothelial cells growth, relaxation, and regulation of blood pressure. Some of these effects could be associated with the purinergic system known for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa11b8836efbf2e028fd9571546d6a01
http://europepmc.org/articles/PMC7889668
http://europepmc.org/articles/PMC7889668
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:1400-1409
Trehalose is a stable, non-reducing disaccharide, which was found recently to stimulate autophagy, limit the inflammatory response and suppress the growth of specific types of cancer. Purinergic signaling and dysregulation of nucleotide metabolism ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0270760902bf63e6885b0c963cbd9d
https://doi.org/10.1080/15257770.2020.1772492
https://doi.org/10.1080/15257770.2020.1772492
Autor:
Jürgen Schrader, Agnieszka Jasztal, Jan Rogowski, Ryszard T. Smolenski, Romuald Lango, Patrycja Jablonska, Christina Alter, Paulina Mierzejewska, Alicja Bulinska, Marcin Serocki, Stefan Chlopicki, Barbara Kutryb-Zajac, Daniela Friebe, Magdi H. Yacoub, Ewa M. Slominska, Rafal Bartoszewski
Publikováno v:
Clinical Research in Cardiology
Background Extracellular nucleotide metabolism contributes to chronic inflammation, cell differentiation, and tissue mineralization by controlling nucleotide and adenosine concentrations and hence its purinergic effects. This study investigated locat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c889905b3c38f9d003f7f493e953fda
https://doi.org/10.1007/s00392-019-01495-x
https://doi.org/10.1007/s00392-019-01495-x