Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paulina M Kowalewska"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e104537 (2014)
BACKGROUND: The heparan sulfate proteoglycan syndecan-1 (CD138) was shown to regulate inflammatory responses by binding chemokines and cytokines and interacting with adhesion molecules, thereby modulating leukocyte trafficking to tissues. The objecti
Externí odkaz:
https://doaj.org/article/019b55a807ef4af39874ae98f16edad8
Autor:
Paulina M. Kowalewska, Justin E. Piazza, Stephanie L. Milkovich, Richard J. Sové, Lin Wang, Shawn N. Whitehead, Christopher G. Ellis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Sepsis is a dysregulated host inflammatory response to infection potentially leading to life-threatening organ dysfunction. The objectives of this study were to determine whether early microvascular dysfunction (MVD) in skeletal muscle can b
Externí odkaz:
https://doaj.org/article/2882ed0426464ea382735ea599cf8c8a
Autor:
Asher A. Mendelson, Casey Lansdell, Alison E. Fox-Robichaud, Patricia Liaw, Jaskirat Arora, Jean-François Cailhier, Gediminas Cepinskas, Emmanuel Charbonney, Claudia dos Santos, Dhruva Dwivedi, Christopher G. Ellis, Dean Fergusson, Kirsten Fiest, Sean E. Gill, Kathryn Hendrick, Victoria T. Hunniford, Paulina M. Kowalewska, Karla Krewulak, Christian Lehmann, Kimberly Macala, John C. Marshall, Laura Mawdsley, Braedon McDonald, Ellen McDonald, Sarah K. Medeiros, Valdirene S. Muniz, Marcin Osuchowski, Justin Presseau, Neha Sharma, Sahar Sohrabipour, Janet Sunohara-Neilson, Gloria Vázquez-Grande, Ruud A. W. Veldhuizen, Donald Welsh, Brent W. Winston, Ryan Zarychanski, Haibo Zhang, Juan Zhou, Manoj M. Lalu, Sepsis Canada’s National Preclinical Sepsis Platform
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by precl
Externí odkaz:
https://doaj.org/article/9aeed005c2d54e4888a280f7bf96c4a3
Role and Molecular Mechanisms of Pericytes in Regulation of Leukocyte Diapedesis in Inflamed Tissues
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Leukocyte recruitment is a hallmark of the inflammatory response. Migrating leukocytes breach the endothelium along with the vascular basement membrane and associated pericytes. While much is known about leukocyte-endothelial cell interactions, the m
Externí odkaz:
https://doaj.org/article/b32b6cea9a7442b08a9b31e33074ab57
Autor:
Paulina M Kowalewska, Jacob Fletcher, William F Jackson, Suzanne E Brett, Michelle SM Kim, Galina Yu Mironova, Nadia Haghbin, David M Richter, Nathan R Tykocki, Mark T Nelson, Donald G Welsh
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:1693-1706
Cerebral blood flow is a finely tuned process dependent on coordinated changes in arterial tone. These changes are strongly tied to smooth muscle membrane potential and inwardly rectifying K+ (KIR) channels are thought to be a key determinant. To elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd28ec5763eec31b6de98cd61798c95d
https://doi.org/10.1177/0271678x221093432
https://doi.org/10.1177/0271678x221093432
Autor:
Sean E. Gill, Ellen McDonald, Christian Lehmann, Victoria T. Hunniford, Marcin F. Osuchowski, Karla D. Krewulak, Asher A. Mendelson, Janet Sunohara-Neilson, Manoj M. Lalu, Gloria Vazquez-Grande, Kathryn Hendrick, Christopher G. Ellis, John Marshall, Sarah K. Medeiros, Sahar Sohrabipour, Dean Fergusson, Dhruva J. Dwivedi, Neha Sharma, Haibo Zhang, Kirsten M. Fiest, Claudia C. dos Santos, Laura Mawdsley, Jaskirat Arora, Gediminas Cepinskas, Alison Fox-Robichaud, Jean-François Cailhier, Patricia C. Liaw, Ryan Zarychanski, Kimberly F. Macala, Brent W. Winston, Valdirene S Muniz, Ruud A. W. Veldhuizen, Justin Presseau, Emmanuel Charbonney, Casey Lansdell, Donald G. Welsh, Juan Zhou, Paulina M. Kowalewska, Braedon McDonald
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-19 (2021)
Intensive Care Medicine Experimental
Intensive Care Medicine Experimental
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ea41fbe1b9f37c1a9f896f76a095d9
https://doaj.org/article/9aeed005c2d54e4888a280f7bf96c4a3
https://doaj.org/article/9aeed005c2d54e4888a280f7bf96c4a3
Autor:
Mohammed A. El‐Lakany, Paulina M. Kowalewska, Shaun L. Sandow, Christopher G. Ellis, Donald G. Welsh
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f240db8cad5bd6448f5d3796adadfd
https://doi.org/10.1096/fasebj.2022.36.s1.r3060
https://doi.org/10.1096/fasebj.2022.36.s1.r3060
Autor:
Paulina M. Kowalewska, Stephanie L. Milkovich, Daniel Goldman, Shaun L. Sandow, Christopher G. Ellis, Donald G. Welsh
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::663a78342fcbaff6948e7ddf59e97654
https://doi.org/10.1096/fasebj.2022.36.s1.r5038
https://doi.org/10.1096/fasebj.2022.36.s1.r5038
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f530397c8d830e7200376efdb71e0d20
https://doi.org/10.1096/fasebj.2022.36.s1.r5180
https://doi.org/10.1096/fasebj.2022.36.s1.r5180
Autor:
Paulina M, Kowalewska, Justin E, Piazza, Stephanie L, Milkovich, Richard J, Sové, Lin, Wang, Shawn N, Whitehead, Christopher G, Ellis
Publikováno v:
Scientific reports. 12(1)
Sepsis is a dysregulated host inflammatory response to infection potentially leading to life-threatening organ dysfunction. The objectives of this study were to determine whether early microvascular dysfunction (MVD) in skeletal muscle can be detecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0147273232e8c5c2ea00fc8293bfc2d2
https://pubmed.ncbi.nlm.nih.gov/35428849
https://pubmed.ncbi.nlm.nih.gov/35428849