Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Paulina M, Getsy"'
Autor:
James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Zackery T. Knauss, Albert Dahan, Jason A. Bubier, Peter M. MacFarlane, Devin Mueller, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract N-acetyl-L-cysteine (L-NAC) is a proposed therapeutic for opioid use disorder. This study determined whether co-injections of L-NAC (500 μmol/kg, IV) or its highly cell-penetrant analogue, L-NAC methyl ester (L-NACme, 500 μmol/kg, IV), pre
Externí odkaz:
https://doaj.org/article/7cf134f1aa4b40f786d4d28221785b6e
Autor:
Jennifer McDonough, Naveen K. Singhal, Paulina M. Getsy, Katherine Knies, Zackery T. Knauss, Devin Mueller, James N. Bates, Derek S. Damron, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We have reported that D,L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going studies reveal that co-injections of D-CYSee with multi-day morphine in
Externí odkaz:
https://doaj.org/article/b770ebd95e5f4062957719f54007718e
Autor:
Paulina M. Getsy, Gregory A. Coffee, James N. Bates, Theodore Parran, Lee Hoffer, Santhosh M. Baby, Peter M. MacFarlane, Zackery T. Knauss, Derek S. Damron, Yee-Hsee Hsieh, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The ability of morphine to decrease cysteine transport into neurons by inhibition of excitatory amino acid transporter 3 (EAA3) may be a key molecular mechanism underlying the acquisition of physical and psychological dependence to morphine. This stu
Externí odkaz:
https://doaj.org/article/25505fc3abd147f1bfb54bb923d7270b
Autor:
Paulina M. Getsy, Walter J. May, Alex P. Young, Santhosh M. Baby, Gregory A. Coffee, James N. Bates, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our lab is investigating the efficacy profiles of tropine analogs against opioid-induced respiratory depression. The companion manuscript reports that the cell-permeant tropeine, tropine ester (Ibutropin), produces a rapid and sustained reversal of t
Externí odkaz:
https://doaj.org/article/206aecfd4bd54baca01b5da85e16ff77
Autor:
Santhosh M. Baby, Walter J. May, Paulina M. Getsy, Gregory A. Coffee, Tej Nakashe, James N. Bates, Alan Levine, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Fentanyl elicits profound disturbances in ventilatory control processes in humans and experimental animals. The traditional viewpoint with respect to fentanyl-induced respiratory depression is that once the effects on the frequency of breathing (Freq
Externí odkaz:
https://doaj.org/article/18e3f66e88b64ca59062ba0937b3b4e6
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse
Externí odkaz:
https://doaj.org/article/5ab96a619e0f445aae20d91926abf672
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules and regulates acetylation of tubulin and other proteins. The possibility that HDAC6 particip
Externí odkaz:
https://doaj.org/article/1a0ad43d74604fba86c7706aa02b3a31
Autor:
Santhosh M. Baby, Walter J. May, Alex P. Young, Christopher G. Wilson, Paulina M. Getsy, Gregory A. Coffee, Tristan H.J. Lewis, Yee-Hee Hsieh, James N. Bates, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116081- (2024)
L-cysteine ethylester (L-CYSee) is a membrane-permeable analogue of L-cysteine with a variety of pharmacological effects. The purpose of this study was to determine the effects of L-CYSee on morphine-induced changes in ventilation, arterial-blood gas
Externí odkaz:
https://doaj.org/article/700e8d74e6a44a1294fa6ee737f3d673
Autor:
Paulina M. Getsy, Gregory A. Coffee, Walter J. May, Santhosh M. Baby, James N. Bates, Stephen J. Lewis
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 498 (2024)
The present study examined the hypothesis that changes in the oxidation–reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic–hyperc
Externí odkaz:
https://doaj.org/article/c8977dbe30884ca2a11ef14cb3934e50
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The o
Externí odkaz:
https://doaj.org/article/d549c8fe16774f9597f7ae5c9d895bb5