Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Paulina Koczurkiewicz-Adamczyk"'
Autor:
Michał Abram, Marcin Jakubiec, Paulina Koczurkiewicz-Adamczyk, Agata Doroz-Płonka, Anna Rapacz, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9861 (2024)
In our current study, we developed a focused series of original ((benzyloxy)benzyl)propanamide derivatives that demonstrated potent activity across in vivo mouse seizure models, specifically, maximal electroshock (MES) and 6 Hz (32 mA) seizures. Amon
Externí odkaz:
https://doaj.org/article/267ad09041614b4a9618339345e9330d
Publikováno v:
Farmacja Polska, Vol 77, Iss 2, Pp 111-120 (2021)
The evolutionary ability to use oxygen in the process of respiration has provided living organisms with an efficient source of energy and made the development of life on Earth possible. However, oxygen and its derivatives can also pose a threat. Duri
Externí odkaz:
https://doaj.org/article/5c95e21a5f4642a7abbb9478636ead24
Autor:
Paulina Koczurkiewicz-Adamczyk, Karolina Grabowska, Elżbieta Karnas, Kamil Piska, Dawid Wnuk, Katarzyna Klaś, Agnieszka Galanty, Katarzyna Wójcik-Pszczoła, Marta Michalik, Elżbieta Pękala, Hendrik Fuchs, Irma Podolak
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1350 (2023)
Saponins are plant metabolites that possess multidirectional biological activities, among these is antitumor potential. The mechanisms of anticancer activity of saponins are very complex and depend on various factors, including the chemical structure
Externí odkaz:
https://doaj.org/article/8ecd642baa3b4e52a26f767551bbf688
Autor:
Marek Jamrozik, Kamil Piska, Adam Bucki, Paulina Koczurkiewicz-Adamczyk, Michał Sapa, Benedykt Władyka, Elżbieta Pękala, Marcin Kołaczkowski
Publikováno v:
Molecules, Vol 28, Iss 9, p 3767 (2023)
Anthracycline antibiotics (ANT) are among the most widely used anticancer drugs. Unfortunately, their use is limited due to the development of drug resistance and cardiotoxicity. ANT metabolism, performed mainly by two enzymes—aldo-keto reductase 1
Externí odkaz:
https://doaj.org/article/d280034150184399a798f5d82a606c5e
Autor:
Vittorio Canale, Wojciech Trybała, Séverine Chaumont-Dubel, Paulina Koczurkiewicz-Adamczyk, Grzegorz Satała, Ophélie Bento, Klaudia Blicharz-Futera, Xavier Bantreil, Elżbieta Pękala, Andrzej J. Bojarski, Frédéric Lamaty, Philippe Marin, Paweł Zajdel
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 12 (2022)
In addition to the canonical Gs adenylyl cyclase pathway, the serotonin type 6 receptor (5-HT6R) recruits additional signaling pathways that control cognitive function, brain development, and synaptic plasticity in an agonist-dependent and independen
Externí odkaz:
https://doaj.org/article/359b495a9fb64b6395f525a0ff337ced
Autor:
Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Bruno Ferreira, Paulina Koczurkiewicz-Adamczyk, Elżbieta Pękala, Elżbieta Wyska, Krzysztof Pociecha, Reinoud Gosens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 423 (2022)
Airway remodeling is a pathological process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway n
Externí odkaz:
https://doaj.org/article/a628a0c1f9554f039d360a1729feea03
Autor:
Karolina Słoczyńska, Justyna Popiół, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz-Adamczyk, Paweł Żmudzki, Elżbieta Pękala
Publikováno v:
Molecules, Vol 27, Iss 6, p 1850 (2022)
This study aimed to assess two novel 5-arylideneimidazolidine-2,4-dione (hydantoin) derivatives (JH3 and JH10) demonstrating photoprotective activity using the reconstructed human skin model EpiskinTM. The skin permeability, irritation, and phototoxi
Externí odkaz:
https://doaj.org/article/25acf10df9c84e33bad4b19a7d7c106c
Autor:
Agnieszka Galanty, Paweł Zagrodzki, Joanna Gdula-Argasińska, Karolina Grabowska, Paulina Koczurkiewicz-Adamczyk, Dagmara Wróbel-Biedrawa, Irma Podolak, Elżbieta Pękala, Paweł Paśko
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 945 (2021)
Usnic acid (UA) is a chiral lichen metabolite with an interesting pharmacological profile. The aim of this study was to compare the anti-melanoma effect of (+)-UA and (−)-UA in an in vitro model by studying their impact on the cells as well as the
Externí odkaz:
https://doaj.org/article/c2243c48f79f45589cb2b1190c43ba22
Autor:
Paulina Koczurkiewicz-Adamczyk, Katarzyna Klaś, Agnieszka Gunia-Krzyżak, Kamil Piska, Kalina Andrysiak, Jacek Stępniewski, Sławomir Lasota, Katarzyna Wójcik-Pszczoła, Józef Dulak, Zbigniew Madeja, Elżbieta Pękala
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6217 (2021)
Doxorubicin (DOX) is a widely used anticancer drug. However, its clinical use is severely limited due to drug-induced cumulative cardiotoxicity, which leads to progressive cardiomyocyte dysfunction and heart failure. Enormous efforts have been made t
Externí odkaz:
https://doaj.org/article/925108ec0bb347078433456221f524be
Autor:
Justyna Popiół, Agnieszka Gunia-Krzyżak, Karolina Słoczyńska, Paulina Koczurkiewicz-Adamczyk, Kamil Piska, Katarzyna Wójcik-Pszczoła, Dorota Żelaszczyk, Anna Krupa, Paweł Żmudzki, Henryk Marona, Elżbieta Pękala
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 34 (2020)
Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of
Externí odkaz:
https://doaj.org/article/b7206d9581b34cacb310fec39941b615