Výsledky vyhledávání - "Paulina Koczurkiewicz-Adamczyk"

Akademický článek

The role of oxidative stress in the etiology of selected civilization diseases

Autor: Paulina Koczurkiewicz-Adamczyk, Bartosz Gąsiorkiewicz, Elżbieta Pękala, Patrycja Bojdo

Publikováno v: Farmacja Polska, Vol 77, Iss 2, Pp 111-120 (2021)

The evolutionary ability to use oxygen in the process of respiration has provided living organisms with an efficient source of energy and made the development of life on Earth possible. However, oxygen and its derivatives can also pose a threat. Duri

Externí odkaz: https://doaj.org/article/5c95e21a5f4642a7abbb9478636ead24

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Akademický článek

Saponin Fraction CIL1 from Lysimachia ciliata L. Enhances the Effect of a Targeted Toxin on Cancer Cells

Autor: Paulina Koczurkiewicz-Adamczyk, Karolina Grabowska, Elżbieta Karnas, Kamil Piska, Dawid Wnuk, Katarzyna Klaś, Agnieszka Galanty, Katarzyna Wójcik-Pszczoła, Marta Michalik, Elżbieta Pękala, Hendrik Fuchs, Irma Podolak

Publikováno v: Pharmaceutics, Vol 15, Iss 5, p 1350 (2023)

Saponins are plant metabolites that possess multidirectional biological activities, among these is antitumor potential. The mechanisms of anticancer activity of saponins are very complex and depend on various factors, including the chemical structure

Externí odkaz: https://doaj.org/article/8ecd642baa3b4e52a26f767551bbf688

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Akademický článek

In Silico and In Vitro Assessment of Carbonyl Reductase 1 Inhibition Using ASP9521—A Potent Aldo-Keto Reductase 1C3 Inhibitor with the Potential to Support Anticancer Therapy Using Anthracycline Antibiotics

Autor: Marek Jamrozik, Kamil Piska, Adam Bucki, Paulina Koczurkiewicz-Adamczyk, Michał Sapa, Benedykt Władyka, Elżbieta Pękala, Marcin Kołaczkowski

Publikováno v: Molecules, Vol 28, Iss 9, p 3767 (2023)

Anthracycline antibiotics (ANT) are among the most widely used anticancer drugs. Unfortunately, their use is limited due to the development of drug resistance and cardiotoxicity. ANT metabolism, performed mainly by two enzymes—aldo-keto reductase 1

Externí odkaz: https://doaj.org/article/d280034150184399a798f5d82a606c5e

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Akademický článek

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Autor: Vittorio Canale, Wojciech Trybała, Séverine Chaumont-Dubel, Paulina Koczurkiewicz-Adamczyk, Grzegorz Satała, Ophélie Bento, Klaudia Blicharz-Futera, Xavier Bantreil, Elżbieta Pękala, Andrzej J. Bojarski, Frédéric Lamaty, Philippe Marin, Paweł Zajdel

Publikováno v: Biomolecules, Vol 13, Iss 1, p 12 (2022)

In addition to the canonical Gs adenylyl cyclase pathway, the serotonin type 6 receptor (5-HT6R) recruits additional signaling pathways that control cognitive function, brain development, and synaptic plasticity in an agonist-dependent and independen

Externí odkaz: https://doaj.org/article/359b495a9fb64b6395f525a0ff337ced

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Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

Autor: Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Bruno Ferreira, Paulina Koczurkiewicz-Adamczyk, Elżbieta Pękala, Elżbieta Wyska, Krzysztof Pociecha, Reinoud Gosens

Publikováno v: Pharmaceuticals, Vol 15, Iss 4, p 423 (2022)

Airway remodeling is a pathological process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway n

Externí odkaz: https://doaj.org/article/a628a0c1f9554f039d360a1729feea03

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Akademický článek

Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model EpiskinTM: Perspectives for Application as Potential Sunscreen Agents

Autor: Karolina Słoczyńska, Justyna Popiół, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz-Adamczyk, Paweł Żmudzki, Elżbieta Pękala

Publikováno v: Molecules, Vol 27, Iss 6, p 1850 (2022)

This study aimed to assess two novel 5-arylideneimidazolidine-2,4-dione (hydantoin) derivatives (JH3 and JH10) demonstrating photoprotective activity using the reconstructed human skin model EpiskinTM. The skin permeability, irritation, and phototoxi

Externí odkaz: https://doaj.org/article/25acf10df9c84e33bad4b19a7d7c106c

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A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers—A Comprehensive In Vitro Approach

Autor: Agnieszka Galanty, Paweł Zagrodzki, Joanna Gdula-Argasińska, Karolina Grabowska, Paulina Koczurkiewicz-Adamczyk, Dagmara Wróbel-Biedrawa, Irma Podolak, Elżbieta Pękala, Paweł Paśko

Publikováno v: Pharmaceuticals, Vol 14, Iss 9, p 945 (2021)

Usnic acid (UA) is a chiral lichen metabolite with an interesting pharmacological profile. The aim of this study was to compare the anti-melanoma effect of (+)-UA and (−)-UA in an in vitro model by studying their impact on the cells as well as the

Externí odkaz: https://doaj.org/article/c2243c48f79f45589cb2b1190c43ba22

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