Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Paulina J. Villanueva"'
Autor:
Jessica D. Hess, Luca H. Macias, Denisse A. Gutierrez, Karla Moran-Santibanez, Lisett Contreras, Stephanie Medina, Paulina J. Villanueva, Robert A. Kirken, Armando Varela-Ramirez, Manuel L. Penichet, Renato J. Aguilera
Publikováno v:
Biology, Vol 11, Iss 6, p 930 (2022)
In recent years, the thienopyrazole moiety has emerged as a pharmacologically active scaffold with antitumoral and kinase inhibitory activity. In this study, high-throughput screening of 2000 small molecules obtained from the ChemBridge DIVERset libr
Externí odkaz:
https://doaj.org/article/ecd0ac3c2f914b6c81921427813e37b2
Autor:
Denisse A. Gutierrez, Lisett Contreras, Paulina J. Villanueva, Edgar A. Borrego, Karla Morán-Santibañez, Jessica D. Hess, Rebecca DeJesus, Manuel Larragoity, Ana P. Betancourt, Jonathon E. Mohl, Elisa Robles-Escajeda, Khodeza Begum, Sourav Roy, Robert A. Kirken, Armando Varela-Ramirez, Renato J. Aguilera
Publikováno v:
Cells, Vol 11, Iss 2, p 254 (2022)
In this study, we identified a novel pyrazole-based derivative (P3C) that displayed potent cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50% cytotoxic concentrations (CC50) in the low micromolar and nanomo
Externí odkaz:
https://doaj.org/article/5cbd8028ab8145fe8e7fc335095f7d64
Autor:
Paulina J Villanueva, Alberto Martinez, Sarah T Baca, Rebecca E DeJesus, Manuel Larragoity, Lisett Contreras, Denisse A Gutierrez, Armando Varela-Ramirez, Renato J Aguilera
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206467 (2018)
The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low m
Externí odkaz:
https://doaj.org/article/8e1041405ca847759a40a39062954a98
Autor:
Denisse A. Gutierrez, Paulina J. Villanueva, Lisett Contreras, Karla Parra, Armando Varela-Ramirez, Renato J. Aguilera, Giulio Francia, Aldo Segura-Cabrera
Publikováno v:
Clin Cancer Drugs
Background: Breast cancer is the most frequently diagnosed cancer in women worldwide. Pyronaridine (PND), an antimalarial drug, was shown to exert anticancer activity on seventeen different human cancer cells, seven from female breast tissue. Additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cb98f13d3eff4f84b3b5c3608e6a81
https://pubmed.ncbi.nlm.nih.gov/35178342
https://pubmed.ncbi.nlm.nih.gov/35178342
Autor:
Manuel Larragoity, Rebecca E. DeJesus, Armando Varela-Ramirez, Lisett Contreras, Paulina J. Villanueva, Sarah T. Baca, Renato J. Aguilera, Alberto Martínez, Denisse A. Gutierrez
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206467 (2018)
PLoS ONE, Vol 13, Iss 11, p e0206467 (2018)
The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9291fb79cc4fe2f899432656a473cc
http://europepmc.org/articles/PMC6218039
http://europepmc.org/articles/PMC6218039
Autor:
Armando Varela-Ramirez, Rebecca E. DeJesus, Renato J. Aguilera, Lisett Contreras, Karol S. Balderrama, Lenore Monterroza, Manuel Larragoity, Paulina J. Villanueva, Denisse A. Gutierrez, Isela A. Rodriguez-Palomares
Publikováno v:
Cell biology and toxicology. 35(6)
In the last 15 years, pyridazinone derivatives have acquired extensive attention due to their widespread biological activities and pharmacological applications. Pyridazinones are well known for their anti-microbial, anti-viral, anti-inflammatory, ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830b5882b607750903c0b1acbc1a8987
https://pubmed.ncbi.nlm.nih.gov/30825052
https://pubmed.ncbi.nlm.nih.gov/30825052