Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Paulina J Stanczyk"'
Autor:
David G. McVey, Catherine Andreadi, Peng Gong, Paulina J. Stanczyk, Charles U. Solomon, Lenka Turner, Liu Yan, Runji Chen, Junjun Cao, Christopher P. Nelson, John R. Thompson, Haojie Yu, Tom R. Webb, Nilesh J. Samani, Shu Ye
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-12 (2024)
Abstract Vascular smooth muscle cell (VSMC) proliferation, migration, and apoptosis play important roles in many physiological processes and pathological conditions. To identify genetic influences on VSMC behavior, we measured these traits and undert
Externí odkaz:
https://doaj.org/article/dda64775ac3d45af905d844b31b95902
Autor:
David Stacey, Lingyan Chen, Paulina J. Stanczyk, Joanna M. M. Howson, Amy M. Mason, Stephen Burgess, Stephen MacDonald, Jonathan Langdown, Harriett McKinney, Kate Downes, Neda Farahi, James E. Peters, Saonli Basu, James S. Pankow, Weihong Tang, Nathan Pankratz, Maria Sabater-Lleal, Paul S. de Vries, Nicholas L. Smith, CHARGE Hemostasis Working Group, Amy D. Gelinas, Daniel J. Schneider, Nebojsa Janjic, Nilesh J. Samani, Shu Ye, Charlotte Summers, Edwin R. Chilvers, John Danesh, Dirk S. Paul
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Many individual genetic risk loci associate with multiple diseases, but the molecular basis of these loci often remains unclear. Here, the authors provide a framework to reveal the genetic cross-disease associations at the PROCR vascular disease locu
Externí odkaz:
https://doaj.org/article/06e0764427f642ea9f1647a016e4fe9d
Autor:
David Stacey, Lingyan Chen, Paulina J. Stanczyk, Joanna M. M. Howson, Amy M. Mason, Stephen Burgess, Stephen MacDonald, Jonathan Langdown, Harriett McKinney, Kate Downes, Neda Farahi, James E. Peters, Saonli Basu, James S. Pankow, Weihong Tang, Nathan Pankratz, Maria Sabater-Lleal, Paul S. de Vries, Nicholas L. Smith, CHARGE Hemostasis Working Group, Amy D. Gelinas, Daniel J. Schneider, Nebojsa Janjic, Nilesh J. Samani, Shu Ye, Charlotte Summers, Edwin R. Chilvers, John Danesh, Dirk S. Paul
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/1a0ca0f841d5435e8760059b3c401a54
Autor:
Elisavet Karamanavi, David G. McVey, Sander W. van der Laan, Paulina J. Stanczyk, Gavin E. Morris, Yifan Wang, Wei Yang, Kenneth Chan, Robin N. Poston, Jun Luo, Xinmiao Zhou, Peng Gong, Peter D. Jones, Junjun Cao, Renata B. Kostogrys, Tom R. Webb, Gerard Pasterkamp, Haojie Yu, Qingzhong Xiao, Peter A. Greer, Emma J. Stringer, Nilesh J. Samani, Shu Ye
Publikováno v:
Circulation Research. 131:1004-1017
Background: Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD) susceptibility; however, the underlying pathobiological mechanism is unclear. This gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffdc37b7942c4b55537e56f5741ce571
https://doi.org/10.1161/circresaha.122.321146
https://doi.org/10.1161/circresaha.122.321146
Autor:
Elisavet, Karamanavi, David G, McVey, Sander W, van der Laan, Paulina J, Stanczyk, Gavin E, Morris, Yifan, Wang, Wei, Yang, Kenneth, Chan, Robin N, Poston, Jun, Luo, Xinmiao, Zhou, Peng, Gong, Peter D, Jones, Junjun, Cao, Renata B, Kostogrys, Tom R, Webb, Gerard, Pasterkamp, Haojie, Yu, Qingzhong, Xiao, Peter A, Greer, Emma J, Stringer, Nilesh J, Samani, Shu, Ye
Publikováno v:
Circulation research. 131(12)
Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD) susceptibility; however, the underlying pathobiological mechanism is unclear. This genetic locus c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33c10e34ff9a9b3fca56252495b255c9
https://pubmed.ncbi.nlm.nih.gov/36321446
https://pubmed.ncbi.nlm.nih.gov/36321446
Autor:
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Publikováno v:
Circulation. 146(12)
Background: Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still unknown for most of these loci, hindering the progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfe759bdc30443933c305dc42c9f8b2
https://pubmed.ncbi.nlm.nih.gov/35735005
https://pubmed.ncbi.nlm.nih.gov/35735005
Autor:
Hossein Ardehali, Justin Geier, Trenton Nicioli, Joshua S. Stoolman, Krishna V. Suresh, Samuel E. Weinberg, Lauren Goodman, Adam De Jesus, Kai Xu, Hsiang-Chun Chang, Paulina J Stanczyk, Chunlei Chen, Navdeep S. Chandel, Carolina M. Pusec, Arianne E. Rodriguez, Brian T. Layden, Issam Ben-Sahra, Jason S. Shapiro, Yihan Chen, Kriti P. Shah, Farnaz Keyhani-Nejad
Publikováno v:
Molecular Cell. 82:1261-1277.e9
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. However, it is not known what dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167b7e76ba820281c52391093f914069
https://doi.org/10.1016/j.molcel.2022.02.028
https://doi.org/10.1016/j.molcel.2022.02.028
Autor:
Issam Ben-Sahra, Hidemichi Kouzu, Adam De Jesus, Jason S. Shapiro, Hsiang-Chun Chang, Yuki Tatekoshi, Perry J. Blackshear, Hossein Ardehali, Paulina J Stanczyk
Publikováno v:
Circulation Research. 127
Introduction: A loss of function mutation in the mRNA binding protein ZFP36L2 has been associated with congenital heart diseases in humans, although the mechanism remains unclear. Objectives: We sought to elucidate the role of ZFP36L2 in the heart us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aabc7669a0f71d67af6f3d3d5b9c31d7
https://doi.org/10.1161/res.127.suppl_1.263
https://doi.org/10.1161/res.127.suppl_1.263
Publikováno v:
Circulation Research. 125
Introduction: Altered DNA damage response (DDR) can result in phenotypic changes that share features with age-associated pathological conditions, including metabolic and cardiovascular abnormalities. Snf1-related kinase (SNRK) is a serine/threonine k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d481d2ed0aa247c61498dd7aaa6eea
https://doi.org/10.1161/res.125.suppl_1.308
https://doi.org/10.1161/res.125.suppl_1.308
Autor:
Cedric Viero, Monika Seidel, Judith White, Paulina J. Stanczyk, Christopher H. George, Spyros Zissimopoulos, F. Anthony Lai
Publikováno v:
Journal of Cell Science
The cardiac muscle ryanodine receptor-Ca2+ release channel (RyR2) constitutes the sarcoplasmic reticulum (SR) Ca2+ efflux mechanism that initiates myocyte contraction, while cardiac myosin-binding protein-C (cMyBP-C; also known as MYBPC3) mediates re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1807e17a991ce07fd2e973c8628feb8
https://hdl.handle.net/10576/13332
https://hdl.handle.net/10576/13332
