Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paulina Chorobik"'
Autor:
Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 211-225 (2022)
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv
Externí odkaz:
https://doaj.org/article/986c7044b75f497b83b535e2846fde7c
Autor:
Anna, Stankiewicz, Katarzyna, Kaczorowska, Ryszard, Bugno, Aneta, Kozioł, Maria H, Paluchowska, Grzegorz, Burnat, Barbara, Chruścicka, Paulina, Chorobik, Piotr, Brański, Joanna M, Wierońska, Beata, Duszyńska, Andrzej, Pilc, Andrzej J, Bojarski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv
Autor:
Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 211-225 (2022)
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e0e789aefc414044bfb30ca3c6530e
Autor:
Andrzej Pilc, Grzegorz Burnat, Tomasz Lenda, Marcin Marciniak, Barbara Chruścicka, Paulina Chorobik, Piotr Brański
Publikováno v:
SLAS Discovery. 20:350-358
A stable and inducible expression of metabotropic glutamate receptor type 4, 7, and 8 was obtained in T-REx 293 cells using the tetracycline system. Tetracycline administration to the cell medium resulted in rapid induction and time- dependent expres
Autor:
Paulina Chorobik, Joanna Bereta
Publikováno v:
Cancer Therapeutic Targets ISBN: 9781461466130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bcc00ae5fe5a5c82abebf09dde9b7a
https://doi.org/10.1007/978-1-4419-0717-2_138
https://doi.org/10.1007/978-1-4419-0717-2_138
Publikováno v:
Infection and Cancer: Bi-Directorial Interactions ISBN: 9783319206684
A growing tumor undergoes processes of heterogenisation and selection resulting in a complex system that facilitates further growth and progression. Immunosuppressive conditions belong to the hallmarks of this microenvironment, as they prevent effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57614ba8705084f65054919b0e26da9a
http://ruj.uj.edu.pl/xmlui/handle/item/23068
http://ruj.uj.edu.pl/xmlui/handle/item/23068
Autor:
Karolina Wójcik-Piotrowicz, Kinga Malina-Novak, Bernadeta Nowak, Walentyna Balwierz, Agata Ziomber, W Zaraska, Piotr J Thor, Paulina Chorobik, Magdalena Ćwiklińska, Jolanta Kaszuba-Zwoińska
Publikováno v:
Cellularmolecular biology letters. 20(1)
Pulsed electromagnetic field (PEMF) influenced the viability of proliferating in vitro peripheral blood mononuclear cells (PBMCs) isolated from Crohn’s disease patients as well as acute myeloblastic leukemia (AML) patients by induction of cell deat
Publikováno v:
Scopus-Elsevier
Bacterial cancer therapy is a concept more than 100 years old - yet, all things considered, it is still in early development. While the use of many passive therapeutics is hindered by the complexity of tumor biology, bacteria offer unique features th
Autor:
Janusz Marcinkiewicz, Paulina Chorobik
Publikováno v:
Polskie Archiwum Medycyny Wewnetrznej. 121(12)
In the course of evolution, bacteria from the genus Salmonella adapted to survive and multiply in a vertebrate host. Skillful use of bacterial interactions with the host immune system became the basis for the development of modified Salmonella-based
Autor:
Zenon Nieckarz, Paulina Chorobik, J. Michalski, Piotr J Thor, Jolanta Kaszuba-Zwoińska, Eugeniusz Rokita, K. Wójcik
Publikováno v:
IFMBE Proceedings ISBN: 9783642235078
Aim of the study is to determine a possible influence of alternating (AC) and static (DC) magnetic fields (MF) combined with chemical factors on U937 human lymphoid cell line viability, when exposed in vitro. U937 cells were cultivated at final densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ded41d42398fcbccf9a889444843c5f
https://doi.org/10.1007/978-3-642-23508-5_339
https://doi.org/10.1007/978-3-642-23508-5_339