Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Paulina B Szklanna"'
Autor:
Shane P Comer, Sarah Cullivan, Paulina B Szklanna, Luisa Weiss, Steven Cullen, Sarah Kelliher, Albert Smolenski, Claire Murphy, Haidar Altaie, John Curran, Katherine O'Reilly, Aoife G Cotter, Brian Marsh, Sean Gaine, Patrick Mallon, Brian McCullagh, Niamh Moran, Fionnuala Ní Áinle, Barry Kevane, Patricia B Maguire, COCOON Study investigators
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001109 (2021)
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date. Although high rates of venous thromboembolism and evidence of COVID-19-induced endot
Externí odkaz:
https://doaj.org/article/accff9fda6ad4f21a599f41124fa2796
Autor:
Shane P. Comer, Ana Le Chevillier, Paulina B. Szklanna, Sarah Kelliher, Khalid Saeed, Steven Cullen, Osasere Edebiri, Tiina O'Neill, Niamh Stephens, Luisa Weiss, Claire A. Murphy, Saraswathi Rajakumar, Alexandra Tierney, Conor Hughes, Áine Lennon, Niamh Moran, Patricia B. Maguire, Fionnuala Ní Áinle, Barry Kevane
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundVaccine-induced thrombotic thrombocytopenia (VITT) post SARS-CoV-2 vaccination is characterized by thrombocytopenia and severe thrombosis. Platelet function during patient recovery in the medium-/long-term has not been investigated fully. H
Externí odkaz:
https://doaj.org/article/e43da276dd40457692b1c34616144286
Autor:
Paulina B. Szklanna, Luisa Weiss, Brian Mac Namee, Rehman Faryal, Barry Kevane, Fionnuala Ní Áinle, Patricia B. Maguire
Publikováno v:
AI in Clinical Medicine. :184-191
Autor:
Patricia B. Maguire, Martin E. Parsons, Paulina B. Szklanna, Monika Zdanyte, Patrick Münzer, Madhumita Chatterjee, Kieran Wynne, Dominik Rath, Shane P. Comer, Melanie Hayden, Fionnuala Ní Áinle, Meinrad Gawaz
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Upon activation, platelets release a host of soluble and vesicular signals, collectively termed the “platelet releasate” (PR). The contents of this PR play a significant role in haemostasis, inflammation, and pathologic sequelae. Despite this, pr
Externí odkaz:
https://doaj.org/article/54d7a47a1c8a471197c7d69f0ca6437b
Autor:
Rosalia Grande, Melania Dovizio, Simone Marcone, Paulina B. Szklanna, Annalisa Bruno, H. Alexander Ebhardt, Hilary Cassidy, Fionnuala Ní Áinle, Anna Caprodossi, Paola Lanuti, Marco Marchisio, Geltrude Mingrone, Patricia B. Maguire, Paola Patrignani
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Rationale: Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified.Objectives: We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed
Externí odkaz:
https://doaj.org/article/6d7e099b74d74b9aaf8873d2be5b2e59
Autor:
Sarah Kelliher, Luisa Weiss, Sarah Cullivan, Ellen O’Rourke, Claire A. Murphy, Shane Toolan, Áine Lennon, Paulina B. Szklanna, Shane P. Comer, Hayley Macleod, Ana Le Chevillier, Sean Gaine, Kate M.A. O’Reilly, Brian McCullagh, John Stack, Patricia B. Maguire, Fionnuala Ní Áinle, Barry Kevane
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:1008-1014
Hypercoagulability and endothelial dysfunction are hallmarks of coronavirus disease 2019 (COVID-19) and appear to predict disease severity. A high incidence of thrombosis despite thromboprophylaxis is reported in patients with moderate to severe COVI
Autor:
Martin E. M. Parsons, Damien McParland, Paulina B. Szklanna, Matthew Ho Zhi Guang, Karen O’Connell, Hugh D. O’Connor, Christopher McGuigan, Fionnuala Ní Áinle, Amanda McCann, Patricia B. Maguire
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 4 (2017)
Nanoparticle tracking analysis (NTA) can be used to quantitate extracellular vesicles (EVs) in biological samples and is widely considered a useful diagnostic tool to detect disease. However, accurately profiling EVs can be challenging due to their s
Externí odkaz:
https://doaj.org/article/e26315b5ff804424971c1e028473ede8
Autor:
Ellen O’Rourke, Fionnuala Ní Áinle, Patricia B. Maguire, Alfonso Blanco, Shane P. Comer, John F. Keaney, Barry Kevane, Luisa Weiss, Aine Lennon, Wido Uhrig, Sean Murphy, Eric Moran, Kieran Wynne, Tadhg Prendiville, Georgi Petrov, Ashish Patel, Karl Egan, Karl Ewins, Paulina B. Szklanna, Sarah Kelliher
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2583-2595
BACKGROUND Rivaroxaban, a direct oral factor Xa inhibitor, mediates anti-inflammatory and cardiovascular-protective effects besides its well-established anticoagulant properties; however, these remain poorly characterized. Extracellular vesicles (EVs
Autor:
Luisa Weiss, Hayley MacLeod, Shane P. Comer, Sarah Cullivan, Paulina B. Szklanna, Fionnuala Ní Áinle, Barry Kevane, Patricia B. Maguire
Publikováno v:
STAR Protocols. 4:102150
Autor:
Patricia B. Maguire, Daniel Angelov, Sarah Kelliher, Paulina B. Szklanna, Barry Kevane, Fionnuala Ní Áinle, Luisa Weiss, Roseann O'Doherty, Karl Ewins
Publikováno v:
Hämostaseologie. 40:594-604
Preeclampsia complicates up to 8% of pregnancies and is a leading cause of fetomaternal morbidity andmortality. Treatment options are limited, with supportive care and delivery of the placenta representing the cornerstone of current management strate