Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paulina, Bekiesch"'
Autor:
Franziska Leipoldt, Javier Santos-Aberturas, Dennis P. Stegmann, Felix Wolf, Andreas Kulik, Rodney Lacret, Désirée Popadić, Daniela Keinhörster, Norbert Kirchner, Paulina Bekiesch, Harald Gross, Andrew W. Truman, Leonard Kaysser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Metalloproteinase inhibitors are leads for drug development, but their biosynthetic pathways are often unknown. Here the authors show that the acyl branched warhead of actinonin and matlystatins derives from an ethylmalonyl-CoA-like pathway and the s
Externí odkaz:
https://doaj.org/article/33d55bdb2e15447e910a355a7a9c3566
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0153249 (2016)
ROK-family proteins have been described to act either as sugar kinases or as transcriptional regulators. Few ROK-family regulators have been characterized so far and most of them are involved in carbon catabolite repression. RokB (Sco6115) has origin
Externí odkaz:
https://doaj.org/article/e09ecdf967f649aaade5da849b85f096
Autor:
Paulina, Bekiesch, Martin, Zehl, Elizabeth, Domingo-Contreras, Jesús, Martín, Ignacio, Pérez-Victoria, Fernando, Reyes, Arthur, Kaplan, Christian, Rückert, Tobias, Busche, Jörn, Kalinowski, Sergey B, Zotchev
Publikováno v:
Journal of Natural Products
Extracts from Streptomyces sp. S4.7 isolated from the rhizosphere of edelweiss, an alpine medicinal plant, exhibited activity against Gram-positive bacteria. LC-HRMS analyses of the extracts resulted in the detection of two unknown, structurally rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::343411a25ff5d62eee6856eaf5bfab7e
https://pubmed.ncbi.nlm.nih.gov/32786880
https://pubmed.ncbi.nlm.nih.gov/32786880
Autor:
Jesús Martín, Sergey B. Zotchev, Arthur Kaplan, Fernando Reyes, Jörn Kalinowski, Elizabeth Domingo-Contreras, Christian Rückert, Martin Zehl, Tobias Busche, Paulina Bekiesch, Ignacio Pérez-Victoria
Extracts from Streptomyces sp. S4.7 isolated from the rhizosphere of edelweiss, an alpine medicinal plant, exhibited activity against Gram-positive bacteria. LC-HRMS analyses of the extracts resulted in the detection of two unknown, structurally rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cdc70f5ccbe61919bff08e8f25921d
https://hdl.handle.net/10668/16094
https://hdl.handle.net/10668/16094
Autor:
Andrew W. Truman, Paulina Bekiesch, Leonard Kaysser, Rodney Lacret, Daniela Keinhörster, Franziska Leipoldt, Désirée Popadić, Andreas Kulik, Harald Gross, Felix Wolf, Javier Santos-Aberturas, Dennis P. Stegmann, Norbert Kirchner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Metalloproteinase inhibitors often feature hydroxamate moieties to facilitate the chelation of metal ions in the catalytic center of target enzymes. Actinonin and matlystatins are potent metalloproteinase inhibitors that comprise rare N-hydroxy-2-pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a629503af6508b7a0ec4fd465ffc4b1
https://doaj.org/article/33d55bdb2e15447e910a355a7a9c3566
https://doaj.org/article/33d55bdb2e15447e910a355a7a9c3566
Publikováno v:
Natural product research. 35(7)
The culture broth of endophytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68fa7b53b889701d8a2d09a336820632
https://pubmed.ncbi.nlm.nih.gov/31303055
https://pubmed.ncbi.nlm.nih.gov/31303055
The culture broth of endophytic Streptomyces sp. AB100, isolated from the shoots of medicinal plant Atropa belladonna (L.) was investigated for the presence of antibacterial compounds. After initial testing followed by bioactivity-guided fractionatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebcb7b0f668421cfedbfe475edeafde
https://doi.org/10.1080/14786419.2019.1639174
https://doi.org/10.1080/14786419.2019.1639174
Publikováno v:
Archiv der Pharmazie. 349:594-601
The fast growing genome databases provide us with a large number of so far unknown secondary metabolite biosynthetic gene clusters. A key method to study these gene clusters is their heterologous expression in an engineered host strain. Gene clusters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::991c0915015ad1b9cf1d3f1d3c718034
https://doi.org/10.1002/ardp.201600058
https://doi.org/10.1002/ardp.201600058
Publikováno v:
ChemInform. 47
The fast growing genome databases provide us with a large number of so far unknown secondary metabolite biosynthetic gene clusters. A key method to study these gene clusters is their heterologous expression in an engineered host strain. Gene clusters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd894697f3b135f5e02aca3f34a7038
https://doi.org/10.1002/chin.201639253
https://doi.org/10.1002/chin.201639253
Autor:
Melanie Brocker, Paulina Bekiesch, Bertolt Gust, Alexander Kristian Apel, Mirita Franz-Wachtel, Karl Forchhammer, Andreas Kulik
Publikováno v:
Applied microbiology and biotechnology. 100(10)
Understanding the regulation of a heterologously expressed gene cluster in a host organism is crucial for activation of silent gene clusters or overproduction of the corresponding natural product. In this study, Streptomyces coelicolor M512(nov-BG1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb604290b3ae44c8c17a56186fc9d36
https://pubmed.ncbi.nlm.nih.gov/26795961
https://pubmed.ncbi.nlm.nih.gov/26795961