Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Autor: Bonagas N; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Gustafsson NMS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Henriksson M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Gustafsson R; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden., Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Borhade S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Green AC; Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Vallin KSA; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Sarno A; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Svensson R; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala University, Uppsala, Sweden., Göktürk C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Pham T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Cookson V; Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Kiweler N; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg., Sandberg L; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Unterlass JE; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Haraldsson M; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Andersson Y; Drug Discovery and Development Platform, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Solna, Sweden., Scaletti ER; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Bengtsson C; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Paulin CBJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Abdurakhmanov E; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Pudelko L; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Kunz B; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Desroses M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Iliev P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Färnegårdh K; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Krämer A; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany., Garg N; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Michel M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Häggblad S; Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Jarvius M; Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Jensen AB; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Almlöf I; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Karsten S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Zhang SM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Häggblad M; Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Eriksson A; Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Liu J; Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Glinghammar B; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Nekhotiaeva N; Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Klingegård F; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Martens U; Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Llona-Minguez S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Moulson R; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Nordström H; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Parrow V; Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden., Dahllund L; Drug Discovery and Development Platform, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Solna, Sweden., Sjöberg B; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Vargas IL; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Vo DD; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Wannberg J; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany., Krokan HE; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Arvidsson PI; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Meiser J; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg., Stenmark P; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Berglund UW; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Homan EJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. thomas.helleday@scilifelab.se.; Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK. thomas.helleday@scilifelab.se.

Publikováno v: Nature cancer [Nat Cancer] 2022 Feb; Vol. 3 (2), pp. 156-172. Date of Electronic Publication: 2022 Feb 28.

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Autor: Visnes T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway., Cázares-Körner A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Hao W; Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA., Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Masuyer G; Department of Biochemistry and Biophysics, Stockholm University, S-106 91 Stockholm, Sweden., Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Mortusewicz O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Sarno A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; The Liaison Committee for Education, Research, and Innovation in Central Norway, Trondheim, Norway., Manoilov A; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.; SciLifeLab, SE-17121 Solna, Sweden., Astorga-Wells J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.; SciLifeLab, SE-17121 Solna, Sweden., Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Pan L; Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA., Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Karsten S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Gokturk C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Grube M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Homan EJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Hanna BMF; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Paulin CBJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Pham T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Berglund UW; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., von Nicolai C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Benitez-Buelga C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Ivanic D; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Iliev P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Krokan HE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; The Liaison Committee for Education, Research, and Innovation in Central Norway, Trondheim, Norway., Baranczewski P; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.; Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics Facility, Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala Drug Optimisation and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden., Artursson P; Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics Facility, Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala Drug Optimisation and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden., Altun M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Jensen AJ; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden., Ba X; Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA., Zubarev RA; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.; SciLifeLab, SE-17121 Solna, Sweden.; Department of Pharmacological and Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, S-106 91 Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Boldogh I; Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. sboldogh@utmb.edu t.helleday@sheffield.ac.uk., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden. sboldogh@utmb.edu t.helleday@sheffield.ac.uk.; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Nov 16; Vol. 362 (6416), pp. 834-839.

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.

Autor: Herold N; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden; Theme of Children's and Women's Health, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. Electronic address: nikolas.herold@ki.se., Rudd SG; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Sanjiv K; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Kutzner J; Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany., Myrberg IH; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden., Paulin CBJ; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Olsen TK; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden., Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Henter JI; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden; Theme of Children's and Women's Health, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Schaller T; Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: torsten.schaller@med.uni-heidelberg.de.

Publikováno v: Experimental hematology [Exp Hematol] 2017 Aug; Vol. 52, pp. 32-39. Date of Electronic Publication: 2017 May 11.

dUTPase inhibition augments replication defects of 5-Fluorouracil.

Autor: Hagenkort A; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Paulin CBJ; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Desroses M; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Sarno A; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Wiita E; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Mortusewicz O; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Koolmeister T; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Loseva O; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Jemth AS; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Almlöf I; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Homan E; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Lundbäck T; Chemical Biology Consortium Sweden, Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Gustavsson AL; Chemical Biology Consortium Sweden, Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Scobie M; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Helleday T; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: Oncotarget [Oncotarget] 2017 Apr 04; Vol. 8 (14), pp. 23713-23726.