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Eight different CD40 mAb shared with soluble trimeric CD40 ligand (sCD40LT) the capacity to rescue germinal center (GC) B cells from spontaneous apoptosis and to suppress antigen receptor-driven apoptosis in group I Burkitt's lymphoma cells. Three mA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::9ab0bc7f9214c5c9a321e345fbeb9aad
http://olympias.lib.uoi.gr/jspui/handle/123456789/20019

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Antibodies to distinct epitopes on the CD40 molecule co-operate in stimulation and can be used for the detection of soluble CD40

Autor: Björck, P, Braesch-Andersen, S, Paulie, S

The B-cell surface protein, CD40, belongs to the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor family and plays a crucial role in T cell-dependent B-cell activation. Ligation of this receptor with antibodies or its recently defined li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cf6d8b06048270f7d7961ea7129e9ef
https://europepmc.org/articles/PMC1415046/

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Inhibition of LFA-1-dependent human B-cell aggregation induced by CD40 antibodies and interleukin-4 leads to decreased IgE synthesis

Autor: Björck, P, Paulie, S

Antibodies to CD40 have been shown to induce homotypic aggregation of human resting B cells and B-cell lines via an LFA-1-dependent mechanism. We show here that interleukin-4 (IL-4) is a strong potentiator of this process and stimulation of tonsillar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e532a0f66ba34eeb1a58c12e415210a4
https://europepmc.org/articles/PMC1421796/

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Interleukin-4-mediated aggregation of anti-IgM-stimulated human B cells: inhibition of aggregation but enhancement of proliferation by antibodies to LFA-1

Autor: Björck, P, Paulie, S, Axelsson, B

Direct cellular interactions, involving adhesion structures like lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1), play a critical role in the initial stages of T-cell-dependent B-cell activation. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::111e285ec28b2f080aa0a305a56e7165
https://europepmc.org/articles/PMC1384813/

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