Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paulette M Tamashiro"'
Autor:
Hideki Furuya, Yoshiko Shimizu, Paulette M. Tamashiro, Kayoko Iino, Jacek Bielawski, Owen T. M. Chan, Ian Pagano, Toshihiko Kawamori
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-8 (2017)
Abstract Background Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis. Methods To further support the evidence, we investigated the effects of SphK1 using thr
Externí odkaz:
https://doaj.org/article/b30332dcf2164ceb8fd574931f035975
Publikováno v:
Biomolecules, Vol 3, Iss 3, Pp 481-513 (2013)
Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advance
Externí odkaz:
https://doaj.org/article/e1fe6cc3384e4fe081ed4d2cba24bb60
Autor:
Yoshiko Shimizu, Paulette M Tamashiro, Kanani Hokutan, Hideki Furuya, Ian Pagano, Brenda Y. Hernandez, Kayoko Iino, Lenora W. M. Loo, Clayton Chong, Charles J. Rosser, Rafael Peres, Steve Goodison, Toshihiko Kawamori, Aung Naing, Owen T. M. Chan
Publikováno v:
Carcinogenesis. 39:47-55
Aberrant sphingolipid metabolism has been reported to promote breast cancer progression. Sphingosine kinase 1 (SphK1) is a key metabolic enzyme for the formation of pro-survival S1P from pro-apoptotic ceramide. The role of SphK1 in breast cancer has
Autor:
Kayoko Iino, Yoshiko Shimizu, Jacek Bielawski, Owen T. M. Chan, Hideki Furuya, Toshihiko Kawamori, Ian Pagano, Paulette M Tamashiro
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-8 (2017)
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-8 (2017)
Background Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis. Methods To further support the evidence, we investigated the effects of SphK1 using three separa
Autor:
Runpu Chen, Hideki Furuya, Toshihiko Kawamori, Lina M. Obeid, Yusuf A. Hannun, Paulette M Tamashiro, Rafael Peres, Yijun Sun, Yoshiko Shimizu, Kayoko Iino
Publikováno v:
Carcinogenesis. 38(12)
Accumulating evidence suggests that the sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) pathway plays a pivotal role in colon carcinogenesis. Our previous studies indicate that the SphK1/S1P pathway mediates colon carcinogenesis at least b
Publikováno v:
Cancer Cell International
Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive loco-regional invasion. Sphingosine kinase1 (SphK1), an enzyme in sphingolipid metabolism, is emerging as a key player in HNSCC pathology. The observation that S
Autor:
Hideki Furuya, Paulette M. Tamashiro, Yoshiko Shimizu, Kayoko Iino, Peres, Rafael, Runpu Chen, Yijun Sun, Yusuf A. Hannun, Lina M. Obeid, Toshihiko Kawamori
Publikováno v:
Carcinogenesis; Dec2017, Vol. 38 Issue 12, p1218-1227, 10p
Autor:
Ian Pagano, Aung Naing, Hideki Furuya, Owen Chan, Rafael Peres, Charles J. Rosser, Lenora W. M. Loo, Kanani Hokutan, Paulette M Tamashiro, Steve Goodison, Kayoko Iino, Toshihiko Kawamori, Brenda Y. Hernandez, Yoshiko Shimizu
Publikováno v:
Molecular Cancer Research. 14:B17-B17
Sphingosine kinase 1 (SphK1) phosphorylates pro-apoptotic sphingosine to form pro-survival sphingosine-1-phosphate (S1P), leading to cancer progression. In breast cancer, high levels of SphK1 mRNA are found in 80% of the patients, with average increa
Autor:
Hideki Furuya, Kayoko Iino, Charles J. Rosser, Toshihiko Kawamori, Paulette M Tamashiro, Yoshiko Shimizu
Publikováno v:
Cancer Research. 75:P6-06
Introduction: The bioactive sphingolipids, ceramide/sphingosine and sphingosine 1-phosphate (S1P) possess opposite effects on cell fate. Sphingosine kinase 1 (SphK1) is an enzyme that principally regulates the balance or the "rheostat" of the sphingo