Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Paulette B. Goforth"'
Autor:
Corentin Cras-Méneur, Alan C. Rupp, Darleen A. Sandoval, Jonathan N. Flak, Matthew J. Sorensen, Nandan Kodur, Paulette B. Goforth, Ahsan Ansari, Martin G. Myers, Alec C. Valenta, James M. Dell’Orco, Chien Li, Paul V. Sabatini, David P. Olson, Nadejda Bozadjieva, Robert T. Kennedy, Alison H. Affinati, Jamie Sacksner
Publikováno v:
J Clin Invest
To identify neurons that specifically increase blood glucose from among the diversely functioning cell types in the ventromedial hypothalamic nucleus (VMN), we studied the cholecystokinin receptor B–expressing (CCKBR-expressing) VMN targets of gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90d48d6e1f8f59387fba9bbf1929941
https://doi.org/10.1172/jci134135
https://doi.org/10.1172/jci134135
Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal
Autor:
James M. Dell’Orco, Amy K. Sutton, David P. Olson, Ian E. Gonzalez, Paulette B. Goforth, Martin G. Myers, Hongjuan Pei
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose and promotes glucose utilization or mobilization during hypoglycemia. The VMH neurons that control these distinct physiologic processes are largely unknown. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e62c80420d42e7b94863922d4437415
http://europepmc.org/articles/PMC8053962
http://europepmc.org/articles/PMC8053962
Autor:
Maja Joosten, Martin G. Myers, Paulette B. Goforth, John M. Hayes, Warren Pan, Christa M. Patterson, Deanna M. Arble, Thomas Lanigan, Jamie Sacksner, Kamal Rahmouni, Eva L. Feldman, Margaret B. Allison, Jonathan N. Flak, Donald A. Morgan, David P. Olson, Randy J. Seeley
Publikováno v:
Journal of Clinical Investigation. 127:3103-3113
Adipocytes secrete the hormone leptin to signal the sufficiency of energy stores. Reductions in circulating leptin concentrations reflect a negative energy balance, which augments sympathetic nervous system (SNS) activation in response to metabolical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0371dbeee4dbe3fab069c04e75604a2
https://doi.org/10.1172/jci90147
https://doi.org/10.1172/jci90147
Autor:
Luis F. Lopez-Santiago, Max F. Oginsky, Paulette B. Goforth, Carrie R. Ferrario, Cameron W Nobile
Publikováno v:
Neuropsychopharmacology
Urges to eat are influenced by stimuli in the environment that are associated with food (food cues). Obese people are more sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exposure. The nucleus accumbens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729315bbad3e83cfebf327753a9ecc0
https://doi.org/10.1038/npp.2016.111
https://doi.org/10.1038/npp.2016.111
Autor:
Darleen A. Sandoval, Paulette B. Goforth, Martin G. Myers, David P. Olson, Jonathan N. Flak, Ahsan Ansari, Paul V. Sabatini, Chien Li
Publikováno v:
Diabetes. 67
While the goal of diabetes treatment is normoglycemia, most therapeutics (especially insulin and insulin secretagogues) carry with them a significant risk of potentially life-threatening hypoglycemia; this risk increases with the intensity of therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eaab71e8f22f234534f275fcc22e636
https://doi.org/10.2337/db18-202-or
https://doi.org/10.2337/db18-202-or
Autor:
Christa M. Patterson, Robert T. Kennedy, Martin G. Myers, Christopher J. Rhodes, Paulette B. Goforth, Amy K. Sutton, Paige A. Malec, Mark Germani, Jenny Marie T. Wong, Giuseppe D'Agostino, Jonathan N. Flak, Justin C. Jones, David P. Olson, Leslie S. Satin, Lora K. Heisler, Michael Rajala, Alastair S. Garfield
Publikováno v:
Nature Neuroscience. 17:1744-1750
Hypoglycemia initiates the counter-regulatory response (CRR), in which the sympathetic nervous system, glucagon and glucocorticoids restore glucose to appropriate concentrations. During starvation, low leptin levels restrain energy utilization, enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c000e1d325129eca8f72675aefcbb6
https://doi.org/10.1038/nn.3861
https://doi.org/10.1038/nn.3861
Autor:
Martin G. Myers, Leslie S. Satin, Gina M. Leinninger, Christa M. Patterson, Paulette B. Goforth
Publikováno v:
The Journal of Neuroscience. 34:11405-11415
The adipocyte-derived hormone leptin modulates neural systems appropriately for the status of body energy stores. Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2aca1b5abec08d9f11944c92f51b09
https://doi.org/10.1523/jneurosci.5167-13.2014
https://doi.org/10.1523/jneurosci.5167-13.2014
Autor:
Arthur Sherman, Leslie S. Satin, Jianhua Ren, Paulette B. Goforth, Craig S. Nunemaker, Christopher D. Waters, Richard Bertram
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 305:E805-E817
We used the patch clamp technique in situ to test the hypothesis that slow oscillations in metabolism mediate slow electrical oscillations in mouse pancreatic islets by causing oscillations in KATP channel activity. Total conductance was measured ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9386353396c89715b1a7f7d09b5f9eec
https://doi.org/10.1152/ajpendo.00046.2013
https://doi.org/10.1152/ajpendo.00046.2013
Publikováno v:
Journal of Neurophysiology. 110:131-140
Alterations in the function and expression of NMDA receptors are observed after in vivo and in vitro traumatic brain injury. We recently reported that mechanical stretch injury in cortical neurons transiently increases the contribution of NMDA recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726990c1c1539a0490e6be350dcc2d3c
https://doi.org/10.1152/jn.01011.2012
https://doi.org/10.1152/jn.01011.2012
Autor:
Paulette B, Goforth, Martin G, Myers
Publikováno v:
Current topics in behavioral neurosciences. 33
The neuropeptide hypocretin is also commonly referred to as orexin, since its orexigenic action was recognized early. Orexin/hypocretin (OX) neurons project widely throughout the brain and the physiologic and behavioral functions of OX are much more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b769d8005f078e60e8838aee03a53e01
https://pubmed.ncbi.nlm.nih.gov/27909992
https://pubmed.ncbi.nlm.nih.gov/27909992