Curcumin and n-acetylcysteine cocrystal produced with supercritical solvent: characterization, solubility, and preclinical evaluation of antinociceptive and anti-inflammatory activities.

Autor: Paulazzi AR; Department of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil., Alves BO; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil., Zilli GAL; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil., Dos Santos AE; Department of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil., Petry F; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil., Soares KD; Pharmaceutical Sciences Graduate Program, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Danielli LJ; Pharmaceutical Sciences Graduate Program, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Pedroso J; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil., Apel MA; Pharmaceutical Sciences Graduate Program, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Aguiar GPS; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil.; Graduate Program in Environmental Sciences, Community University of Chapecó Region (Unochapecó), Servidão Anjo da Guarda, nº 295-D, Bairro Efapi, Chapecó, SC, 89809-900, Brazil., Siebel AM; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil.; Graduate Program in Environmental Sciences, Community University of Chapecó Region (Unochapecó), Servidão Anjo da Guarda, nº 295-D, Bairro Efapi, Chapecó, SC, 89809-900, Brazil., Oliveira JV; Department of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, Florianópolis, SC, Brazil., Müller LG; Molecular Genetics and Ecotoxicology Laboratory, Community University of Chapecó Region, Chapecó, SC, Brazil. lizmuller@unochapeco.edu.br.; Graduate Program in Environmental Sciences, Community University of Chapecó Region (Unochapecó), Servidão Anjo da Guarda, nº 295-D, Bairro Efapi, Chapecó, SC, 89809-900, Brazil. lizmuller@unochapeco.edu.br.

Publikováno v: Inflammopharmacology [Inflammopharmacology] 2022 Feb; Vol. 30 (1), pp. 327-341. Date of Electronic Publication: 2022 Jan 10.