Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Paula-Fernanda Kinoshita"'
Autor:
Fanny Eysert, Paula-Fernanda Kinoshita, Julien Lagarde, Sandra Lacas-Gervais, Laura Xicota, Guillaume Dorothée, Michel Bottlaender, Frédéric Checler, Marie-Claude Potier, Marie Sarazin, Mounia Chami
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients and their potential correlation with disease progression are underinvestigated. We studied
Externí odkaz:
https://doaj.org/article/c121b4ea0df94f49962210d816a22ca2
Autor:
Vinicius Wanatable Nakao, Caio Henrique Yokowama Mazucanti, Larissa de Sá Lima, Paloma Segura de Mello, Natacha Medeiros de Souza Port’s, Paula Fernanda Kinoshita, Jacqueline Alves Leite, Elisa Mitiko Kawamoto, Cristoforo Scavone
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytoki
Externí odkaz:
https://doaj.org/article/68d440f26bb4423290f31765cc6d931a
Autor:
Israel José Pereira Garcia, Paula Fernanda Kinoshita, Jéssica Martins de Moura Valadares, Luciana Estefani Drumond de Carvalho, Vanessa Faria Cortes, Leandro Augusto Barbosa, Cristoforo Scavone, Hérica de Lima Santos
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 920 (2023)
A lipopolysaccharide (LPS)-induced neuroinflammation rat model was used to study the effects of ouabain (OUA) at low concentrations, which can interact with the Na,K-ATPase, causing the modulation of intracellular signalling pathways in the Central N
Externí odkaz:
https://doaj.org/article/830e2b758a314e83ba24b3a93d10576c
Autor:
Paula Fernanda Kinoshita, Ana Maria Orellana, Diana Zukas Andreotti, Giovanna Araujo de Souza, Natalia Prudente de Mello, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Cristoforo Scavone
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2937 (2022)
Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain. TNF plays an essential role in neuroinflammation and re
Externí odkaz:
https://doaj.org/article/b01cca83c00a44229072e45465618de6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Inflammation is a response to a lesion in the tissue or infection. This process occurs in a specific manner in the central nervous system and is called neuroinflammation, which is involved in neurodegenerative diseases. GPNMB, an endogenous glycoprot
Externí odkaz:
https://doaj.org/article/eb37c910e26c4246ab4d2637e857dab5
Autor:
Fanny Eysert, Paula Fernanda Kinoshita, Arnaud Mary, Loan Vaillant-Beuchot, Frédéric Checler, Mounia Chami
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9521 (2020)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative pathology characterized by a progressive decline of cognitive functions. Alteration of various signaling cascades affecting distinct subcellular compartment functions and their communic
Externí odkaz:
https://doaj.org/article/df7bb6f24f8d479b94de124180a52a70
Autor:
Israel José Pereira Garcia, Paula Fernanda Kinoshita, Jéssica Martins de Moura Valadares, Luciana Estefani Drumond de Carvalho, Vanessa Faria Cortes, Leandro Augusto Barbosa, Cristoforo Scavone, Hérica de Lima Santos
Publikováno v:
Biomedicines; Volume 11; Issue 3; Pages: 920
A lipopolysaccharide (LPS)-induced neuroinflammation rat model was used to study the effects of ouabain (OUA) at low concentrations, which can interact with the Na, K-ATPase, causing the modulation of intracellular signalling pathways in the central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b42eded1ced12b649ab59bb52fd096
https://doi.org/10.21203/rs.3.rs-2135374/v1
https://doi.org/10.21203/rs.3.rs-2135374/v1
Autor:
Alexandre Denadai-Souza, Adriana Oliveira Manfiolli, L. M. Yshii, Marcelo D. Gomes, Paula Fernanda Kinoshita, Cristoforo Scavone
Publikováno v:
IBRO Reports, Vol 9, Iss, Pp 218-223 (2020)
IBRO Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
IBRO Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Highlights • TRAF6 binds to both WT and the mutant form A30 P asyn in SH-SY5Y cell model. • The activation of NF-κB leads to changes in cytokines levels induced by TRAF6 - WT asyn interaction decreasing cell viability. • The interaction betwee
Autor:
Paula Fernanda Kinoshita, Jacqueline Alves Leite, Ana Maria Marques Orellana, Andrea Rodrigues Vasconcelos, Luis Eduardo M Quintas, Elisa Mitiko Kawamoto, Cristoforo eScavone
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Decreased Na+,K+-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β and γ, with four distinct isoforms of the catalytic α subunit (α1-4). Genet
Externí odkaz:
https://doaj.org/article/06fa27ff105c41a79529f428e56b0d0a
Autor:
Ana Maria Marques Orellana, Paula Fernanda Kinoshita, Jacqueline Alves Leite, Elisa Mitiko Kawamoto, Cristoforo eScavone
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
Cardiotonic steroids (CTS) are a class of specific ligands of the Na+,K+- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through a
Externí odkaz:
https://doaj.org/article/ed493f42db374162b0c59ed13d3b459c