Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Paula W. Allan"'
Autor:
Disha Joshi, Eric J. Sorscher, Steven E. Ealick, Bhagelu R. Achyut, William B. Parker, Paula W. Allan, Melissa Gilbert-Ross, Turang E. Behbahani, Jeong S. Hong, William R. Waud, Regina Rab
Publikováno v:
Cancer Chemother Pharmacol
Treatment with fludarabine phosphate (9-β-D-arabinofuranosyl-2-F-adenine 5'-phosphate, F-araAMP) leads to regressions and cures of human tumor xenografts that express Escherichia coli purine nucleoside phosphorylase (EcPNP). This occurs despite the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15e03a90009b04658dba36de2c2c3dd
https://pubmed.ncbi.nlm.nih.gov/31915968
https://pubmed.ncbi.nlm.nih.gov/31915968
Autor:
Abdalla E. A. Hassan, John A. Secrist, Paula W. Allan, Reham A. I. Abou-Elkhair, William B. Parker
Publikováno v:
Bioorganic Chemistry. 65:9-16
6-Methylpurine (MeP) is cytotoxic adenine analog that does not exhibit selectivity when administered systemically, and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli PNP. The prototype MeP releasing pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5f1b1f0795cb27c3e6660ae64956e4
https://doi.org/10.1016/j.bioorg.2015.12.006
https://doi.org/10.1016/j.bioorg.2015.12.006
Publikováno v:
Biochemical and Biophysical Research Communications. 461:65-69
In Vibrio cholerae, the genes required for biofilm development are repressed by quorum sensing at high cell density due to the accumulation in the medium of two signaling molecules, cholera autoinducer 1 (CAI-1) and autoinducer 2 (AI-2). A significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc1f823ab3d2972496382b5b85f6ff9
https://doi.org/10.1016/j.bbrc.2015.03.170
https://doi.org/10.1016/j.bbrc.2015.03.170
Publikováno v:
Cancer Gene Therapy
The use of E. coli purine nucleoside phosphorylase (PNP) to activate prodrugs has demonstrated excellent activity in the treatment of various human tumor xenografts in mice. E. coli PNP cleaves purine nucleoside analogs to generate toxic adenine anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c1c91aed4a5504a83e4324c926143a
http://europepmc.org/articles/PMC3096718
http://europepmc.org/articles/PMC3096718
Autor:
Paula W. Allan, Steven E. Ealick, You Na Kang, Jing Wen Ting, Yang Zhang, William B. Parker, Chi Yao Chang
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 66:155-162
Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine ribonucleosides to the corresponding free bases and ribose 1-phosphate. The crystal structure of grouper iridovirus PNP (givPNP), corresponding to the first PNP g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2881063e3983d5e6611b89191c41de87
https://doi.org/10.1107/s0907444909048276
https://doi.org/10.1107/s0907444909048276
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 28:642-656
Metalation of 6-methyl-9-(tetrahydro-2H-pyran-2-yl)purine (10) with lithiating agents of varying basicities such as n-BuLi and LiHMDS in THF at -78 degrees C resulted in metalation at both of the 6-CH(3) moiety and the 8-CH position, irrespective of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc21802580b88804a4b96d2b25d885e3
https://doi.org/10.1080/15257770903091938
https://doi.org/10.1080/15257770903091938
Autor:
Paula W. Allan, Reham A. I. Abou-Elkhair, William B. Parker, Abdalla E. A. Hassan, John A. Secrist
Publikováno v:
European journal of medicinal chemistry. 108
Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue. 6-Methylpurine (MeP) is anothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87ba979777a3aeb7ca5f25d117f6c67
https://pubmed.ncbi.nlm.nih.gov/26724729
https://pubmed.ncbi.nlm.nih.gov/26724729
Autor:
William R. Carroll, Eric J. Sorscher, Eben L. Rosenthal, F. R. Hunt, Lisle Nabell, Robert M. Conry, Deborah Lowman, Joshua S. Richman, Thomas K. Chung, Jeong S. Hong, Kyle Mannion, William B. Parker, Lisa Clemons, Paula W. Allan
The use of Escherichia coli purine nucleoside phosphorylase (PNP) to activate fludarabine has demonstrated safety and antitumor activity during preclinical analysis and has been approved for clinical investigation.A first-in-human phase I clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f233cacf0aaaccc17c0621882bdcd550
https://europepmc.org/articles/PMC4560028/
https://europepmc.org/articles/PMC4560028/
Autor:
Paula W. Allan, John A. Secrist, William B. Parker, Eric J. Sorscher, Abdalla E. A. Hassan, William R. Waud, Anita T. Fowler, A. V. Silamkoti, S.E. Ealick
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:387-392
Our studies have led to the identification of an E. coli PNP mutant (M64V) that is able to cleave numerous 5'-modified nucleoside analogs with much greater efficiency than the wild-type enzyme. The biological activity of the three best substrates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bb9d7dd9a272d7de8b791e98c75d06
https://doi.org/10.1081/ncn-200059807
https://doi.org/10.1081/ncn-200059807
Autor:
William R. Waud, Bryan A. Moore, Eric J. Sorscher, Hui Wen, Jeong S. Hong, Paula W. Allan, Zsuzsa Bebok, Tim M. Townes, John A. Secrist, William B. Parker, Sylvia A. McPherson, Dana N. Levasseur
Publikováno v:
Cancer Research. 64:6610-6615
Escherichia coli purine nucleoside phosphorylase (PNP) expressed in tumors converts relatively nontoxic prodrugs into membrane-permeant cytotoxic compounds with high bystander activity. In the present study, we examined tumor regressions resulting fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93f5081a4855573bef15e9ad443b1343
https://doi.org/10.1158/0008-5472.can-04-0012
https://doi.org/10.1158/0008-5472.can-04-0012