Výsledky vyhledávání - "Paula Voabil"

Akademický článek

Protocol for ex vivo culture of patient-derived tumor fragments

Autor: Lisanne M. Roelofsen, Paula Voabil, Marjolein de Bruijn, Petra Herzig, Alfred Zippelius, Ton N. Schumacher, Daniela S. Thommen

Publikováno v: STAR Protocols, Vol 4, Iss 2, Pp 102282- (2023)

Summary: The lack of suitable models currently hampers our understanding of how the tumor microenvironment responds to immunotherapy treatment. Here, we present a protocol for ex vivo culture of patient-derived tumor fragments (PDTFs). We describe th

Externí odkaz: https://doaj.org/article/c2276a0502114ffd841cacb2749b9c77

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An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer

Autor: Simone Brokamp, Annegien Broeks, Christian U. Blank, Petra Herzig, Marlous van den Braber, Daniela S. Thommen, Alfred Zippelius, Marjolein de Bruijn, Joyce Sanders, Ton N. Schumacher, Lisanne M. Roelofsen, Koen J. Hartemink, John B. A. G. Haanen, Kim Monkhorst, Paula Voabil, Sanne H. Hendriks

Publikováno v: Nature Medicine. 27:1250-1261

Inhibitors of the PD-1–PD-L1 axis have been approved as therapy for many human cancers. In spite of the evidence for their widespread clinical activity, little is known about the immunological alterations that occur in human cancer tissue after PD-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c45c19b51a9c099f12311a77da46c458
https://doi.org/10.1038/s41591-021-01398-3

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Addition of interleukin-2 overcomes resistance to neoadjuvant CTLA4 and PD1 blockade in ex vivo patient tumors

Autor: Paulien Kaptein, Celia Jacoberger-Foissac, Petros Dimitriadis, Paula Voabil, Marjolein de Bruijn, Simone Brokamp, Irene Reijers, Judith Versluis, Gahyathiri Nallan, Hannah Triscott, Elizabeth McDonald, Joshua Tay, Georgina V. Long, Christian U. Blank, Daniela S. Thommen, Michele W.L. Teng

Publikováno v: Science Translational Medicine, 14(642). AMER ASSOC ADVANCEMENT SCIENCE

Neoadjuvant immunotherapy with anti-cytotoxic T lymphocyte–associated protein 4 (CTLA4) + anti–programmed cell death protein 1 (PD1) monoclonal antibodies has demonstrated remarkable pathological responses and relapse-free survival in ~80% of pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6676795225993de96cda1c9757ccd80f
https://doi.org/10.1126/scitranslmed.abj9779

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An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer

Autor: Paula, Voabil, Marjolein, de Bruijn, Lisanne M, Roelofsen, Sanne H, Hendriks, Simone, Brokamp, Marlous, van den Braber, Annegien, Broeks, Joyce, Sanders, Petra, Herzig, Alfred, Zippelius, Christian U, Blank, Koen J, Hartemink, Kim, Monkhorst, John B A G, Haanen, Ton N, Schumacher, Daniela S, Thommen

Publikováno v: Nature medicine. 27(7)

Inhibitors of the PD-1-PD-L1 axis have been approved as therapy for many human cancers. In spite of the evidence for their widespread clinical activity, little is known about the immunological alterations that occur in human cancer tissue after PD-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8094aee10c0eedb40999c71de5771837
https://pubmed.ncbi.nlm.nih.gov/34478641

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Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model

Autor: Jacques Bauer, Joana Liberal, Paula Voabil, José Cunha-Vaz, António F. Ambrósio, Ermelindo C. Leal, Ana Raquel Santiago

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

Calcium dobesilate (CaD) has been prescribed to some patients in the early stages of diabetic retinopathy to delay its progression. We previously reported that the treatment of diabetic animals (4 weeks of diabetes) with CaD, during the last 10 days

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3853a32586018100386f6ff6fc09a0
https://doi.org/10.1159/000478784

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Abstract B050: Identification of PD-1T TILs and CXCL13 as determinants for response to anti-PD-1 treatment using human tumor explants

Autor: Kirsten D. Mertz, Alfred Zippelius, Petra Herzig, Daniela S. Thommen, Viktor H. Koelzer, John B. A. G. Haanen, Marjolein de Bruijn, Marlous van den Braber, Ton N. Schumacher, Kim Monkhorst, Paula Voabil, Karlijn Hummelink

Publikováno v: Cancer Immunology Research. 7:B050-B050

Reinvigoration of tumor-specific T-cells by cancer immunotherapies, in particular PD-1/PD-L1 blocking agents, has greatly improved clinical outcome in multiple cancer types. Nevertheless, durable clinical benefit is currently limited to a small numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb62dd47fc1063e6b9b519786b0d479c
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b050

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Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes

Autor: Jacques Bauer, Joana Liberal, José Cunha-Vaz, Carlo Chiavaroli, António F. Ambrósio, João Martins, Paula Voabil, Ermelindo C. Leal

Publikováno v: Diabetes

OBJECTIVECalcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy in the last decades, but its mechanisms of action are not elucidated. CaD is able to correct the excessive vascular permeability in the retina of diabetic patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74340e4ed328bb6c7db80d6d48413552
http://europepmc.org/articles/PMC3279541

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Global Mass Spectrometry and Transcriptomics Array Based Drug Profiling Provides Novel Insight into Glucosamine Induced Endoplasmic Reticulum Stress*

Autor: Helena Ribeiro, Ana Sofia Carvalho, Ole N. Jensen, Deborah Penque, Henrik Molina, Paula Voabil, Rune Matthiesen

Publikováno v: Carvalho, A S, Ribeiro, H, Voabil, P, Penque, D, Jensen, O N, Molina, H & Matthiesen, R 2014, ' Global mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced endoplasmic reticulum stress ', Molecular & Cellular Proteomics, vol. 13, no. 12, pp. 3294-307 . https://doi.org/10.1074/mcp.M113.034363

We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to nonsteroidal anti-inflammatory drugs, for decreasing pain, inflammation, and maintaining healthy joints. Numerous studies have reported an array of mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8031b10e8f8c5a58b7a2ff2748946b7
https://europepmc.org/articles/PMC4256484/

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Tools for protein posttranslational modifications analysis: FAK, a case study

Autor: Catarina, Fonseca, Paula, Voabil, Ana Sofia, Carvalho, Rune, Matthiesen

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1007

Recent advances in mass spectrometry have resulted in an exponential increase in annotation of posttranslational modifications (PTMs). Just in the Swiss-Prot Knowledgebase, there are 89,931 of a total of 27 characterized PTM types reported experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::228a89737c45c8acd084cb1cf1ff5a2c
https://pubmed.ncbi.nlm.nih.gov/23666734

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Tools for Protein Posttranslational Modifications Analysis: FAK, a Case Study

Autor: Catarina Fonseca, Ana Sofia Carvalho, Paula Voabil, Rune Matthiesen

Publikováno v: Mass Spectrometry Data Analysis in Proteomics ISBN: 9781627033916

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1947fd9faadded4da4bdb04290ee08d9
https://doi.org/10.1007/978-1-62703-392-3_15

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