LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression.

Autor: Nicholas S Kirkby, Anne K Zaiss, Paula Urquhart, Jing Jiao, Philip J Austin, Malak Al-Yamani, Martina H Lundberg, Louise S MacKenzie, Timothy D Warner, Anna Nicolaou, Harvey R Herschman, Jane A Mitchell

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69524 (2013)

There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found

Externí odkaz: https://doaj.org/article/18a323ab2fc043b0bc1ea6141626660a

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery

Autor: Sapan D. Gandhi, Kevin C. Baker, Sara M. Rankin, Moïra François, Daniel Possley, Michael D. Newton, Andia N. Redpath, Paula Urquhart, Adam M. Fahs, Dominique Bonnet, Anna Nicolaou, Tariq G. Fellous, Kate H C Gowers, Suet-Ping Wong, Samantha E. Hartner, Mackenzie M Fleischer

Publikováno v: NPJ Regenerative Medicine
npj Regenerative Medicine
npj Regenerative Medicine, 2020, 5 (1), ⟨10.1038/S41536-020-0088-1⟩
Fellous, T G, Redpath, A N, Fleischer, M M, Gandhi, S, Hartner, S E, Newton, M D, François, M, Wong, S, Gowers, K H C, Fahs, A M, Possley, D R, Bonnet, D, Urquhart, P, Nicolaou, A, Baker, K C & Rankin, S M 2020, ' Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery ', Regenerative Medicine, vol. 5, no. 1 . https://doi.org/10.1038/s41536-020-0088-1
npj Regenerative Medicine, Vol 5, Iss 1, Pp 1-11 (2020)

Therapeutic approaches requiring the intravenous injection of autologous or allogeneic mesenchymal stromal cells (MSCs) are currently being evaluated for treatment of a range of diseases, including orthopaedic injuries. An alternative approach would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0fb63384f078e79a23facad08cb50f
http://europepmc.org/articles/PMC7035363

Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid supplementation

Autor: Anna Nicolaou, Francesco Del Carratore, Suzanne M. Pilkington, Rachel E.B. Watson, Paula Urquhart, Rainer Breitling, Sharon Murphy, Lesley E. Rhodes, Anggit L. Sunarwidhi, Magdalena Kiezel-Tsugunova, Alexandra C. Kendall

Publikováno v: Kendall, A, Pilkington, S, Murphy, S, Del Carratore, F, Sunarwidhi, A L, Kiezel-Tsugunova, M, Urquhart, P, Watson, R, Breitling, R, Rhodes, L & Nicolaou, A 2019, ' Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid supplementation ', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology . https://doi.org/10.1096/fj.201901501R
Kendall, A C, Pilkington, S M, Murphy, S A, Del Carratore, F, Sunarwidhi, A L, Kiezel-Tsugunova, M, Urquhart, P, Watson, R E B, Breitling, R, Rhodes, L E & Nicolaou, A 2019, ' Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation ', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 33, no. 11, pp. 13014-13027 . https://doi.org/10.1096/fj.201901501R PDF
The FASEB Journal

Nutritional supplementation with fish oil or ω-3 (n-3) polyunsaturated fatty acids (PUFAs) has potential benefits for skin inflammation. Although the differential metabolism of the main n-3PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b186e714dac6c239b2304815749a475
https://www.research.manchester.ac.uk/portal/en/publications/dynamics-of-the-human-skin-mediator-lipidome-in-response-to-dietary-omega3-fatty-acid-supplementation(ab9e1fdd-dd71-46a4-ba1a-917709e21411).html

Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases

Autor: David F. Woodward, Paula Urquhart, Anna Nicolaou

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851:366-376

The naturally occurring mammalian endocannabinoids possess biological attributes that extend beyond interaction with cannabinoid receptors. These extended biological properties are the result of oxidative metabolism of the principal mammalian endocan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0c36d0d04e05da2e68b2915ccbcf90
https://doi.org/10.1016/j.bbalip.2014.12.015

N-Glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells

Autor: Paula Urquhart, Nigel M. Hooper, Susan Pang

Publikováno v: Journal of Cell Science. 117:5079-5086

The glycosyl-phosphatidylinositol (GPI) anchor mediates the apical sorting of proteins in polarised epithelial cells through its interaction with lipid rafts. Here we investigated the signals required for the apical targeting of the naturally N-glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf630271867f46e34f9296f1c789736e
https://doi.org/10.1242/jcs.01386