Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Paula Tito"'
Autor:
David B. Archer, Margaret Sunde, Carol V. Robinson, Denis Canet, Christina Redfield, Christopher M. Dobson, Andrew Spencer, Paula Tito
Publikováno v:
Nature Structural Biology. 9:308-315
Hydrogen exchange experiments monitored by NMR and mass spectrometry reveal that the amyloidogenic D67H mutation in human lysozyme significantly reduces the stability of the beta-domain and the adjacent C-helix in the native structure. In addition, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11cb2faebf927ac8b3fd9124e6da1af
https://doi.org/10.1038/nsb768
https://doi.org/10.1038/nsb768
Autor:
Carol V. Robinson, Margaret Sunde, Mario Bouchard, Ewan J. Nettleton, Paula Tito, Christopher M. Dobson
Publikováno v:
Biophysical Journal. 79:1053-1065
The self-assembly and aggregation of insulin molecules has been investigated by means of nanoflow electrospray mass spectrometry. Hexamers of insulin containing predominantly two, but up to four, Zn2+ ions were observed in the gas phase when solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad3aee90d00b6cd2efc37cd0991112a
https://doi.org/10.1016/s0006-3495(00)76359-4
https://doi.org/10.1016/s0006-3495(00)76359-4
Publikováno v:
Methods in enzymology. 402
We describe the use of nano-electrospray ionization (nano-ESI) mass spectrometry (MS) for monitoring hydrogen exchange. Using this approach, we have compared the fluctuations in structure of the wild-type human lysozyme with those of the Asp67His and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8489c0bfc40fddd4ab0a3df4a3ace327
https://pubmed.ncbi.nlm.nih.gov/16401516
https://pubmed.ncbi.nlm.nih.gov/16401516
We describe the use of nano‐electrospray ionization (nano‐ESI) mass spectrometry (MS) for monitoring hydrogen exchange. Using this approach, we have compared the fluctuations in structure of the wild‐type human lysozyme with those of the Asp67H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f1392f8bc2fce2c365a2e75693bf96
https://doi.org/10.1016/s0076-6879(05)02012-4
https://doi.org/10.1016/s0076-6879(05)02012-4
Autor:
Carol V. Robinson, N.R. Brown, Louise N. Johnson, Paula Tito, Jane A. Endicott, Helena Hernández, Alison M. Lawrie, Martin E.M. Noble
Publikováno v:
Protein expression and purification. 23(2)
The cyclin-dependent kinase-activating kinase (CAK) catalyzes the phosphorylation of the cyclin-dependent protein kinases (CDKs) on a threonine residue (Thr160 in human CDK2). The reaction is an obligatory step in the activation of the CDKs. In highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8675bc3a73886b2b3065c7d9d57b43
https://pubmed.ncbi.nlm.nih.gov/11676600
https://pubmed.ncbi.nlm.nih.gov/11676600
Publikováno v:
Biophysical journal. 78(2)
The binding of sodium ions to the transmembrane channel peptide gramicidin A has permitted the use of electrospray ionization mass spectrometry to study its conformation in different solvent environments. The mass spectra of the peptide in the variou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a7e7ba4300197e029c6ee4a298284e
http://ora.ox.ac.uk/objects/uuid:9ad9776b-8ed0-46c6-aaf4-e4e126389591
http://ora.ox.ac.uk/objects/uuid:9ad9776b-8ed0-46c6-aaf4-e4e126389591