Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paula Stubbemann"'
Autor:
Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, 3rd, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109330- (2024)
Summary: Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-co
Externí odkaz:
https://doaj.org/article/7c9c5701df2748eb9bb1238451f24137
Autor:
Peter Körtvelyessy, Elena Diekämper, Klemens Ruprecht, Matthias Endres, Paula Stubbemann, Florian Kurth, Jan Adriaan Graw, Mario Menk, Jens Kuhle, Felix Wohlrab
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-7 (2023)
Abstract COVID-19 is associated with various neurological symptoms. Serum neurofilament light chain (sNfL) is a robust marker for neuroaxonal injury. Recent studies have shown that elevated levels of sNfL are associated with unfavorable outcome in CO
Externí odkaz:
https://doaj.org/article/f273d3422f4f494ab0ce4280f80aa433
Autor:
Dirk Reinhold, Vadim Farztdinov, Yan Yan, Christian Meisel, Henrik Sadlowski, Joachim Kühn, Frank H. Perschel, Matthias Endres, Emrah Düzel, Stefan Vielhaber, Karina Guttek, Alexander Goihl, Morten Venø, Bianca Teegen, Winfried Stöcker, Paula Stubbemann, Florian Kurth, Leif E. Sander, Markus Ralser, Carolin Otto, Simon Streit, Sven Jarius, Klemens Ruprecht, Helena Radbruch, Jørgen Kjems, Michael Mülleder, Frank Heppner, Peter Körtvelyessy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manife
Externí odkaz:
https://doaj.org/article/2185b49e6e60455db4212f740b0223ba
Autor:
Charlotte Thibeault, Lara Bardtke, Kanika Vanshylla, Veronica di Cristanziano, Kirsten A. Eberhardt, Paula Stubbemann, David Hillus, Pinkus Tober-Lau, Parnika Mukherjee, Friederike Münn, Lena J. Lippert, Elisa T. Helbig, Tilman Lingscheid, Fridolin Steinbeis, Mirja Mittermaier, Martin Witzenrath, Thomas Zoller, Pa-COVID study group, Florian Klein, Leif E. Sander, Florian Kurth
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
BACKGROUND After its introduction as standard-of-care for severe COVID-19, dexamethasone has been administered to a large number of patients globally. Detailed knowledge of its impact on the cellular and humoral immune response to SARS-CoV-2 remains
Externí odkaz:
https://doaj.org/article/229b1b6d598e45c5912da9fc1d7b7970
Autor:
Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J Lippert, Elisa T Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, PA-COVID-19 Study group, Florian Kurth, Markus Ralser
Publikováno v:
PLOS Digital Health, Vol 1, Iss 1, p e0000007 (2022)
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited per
Externí odkaz:
https://doaj.org/article/8c7d05377e464ce084389ab5400bb7df
Autor:
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmüller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Publikováno v:
Nature immunology 24(6), 979-990 (2023). doi:10.1038/s41590-023-01517-x
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fa2efef3db05d38b32977cd1c0284b
Autor:
David Hillus, Tatjana Schwarz, Pinkus Tober-Lau, Kanika Vanshylla, Hana Hastor, Charlotte Thibeault, Stefanie Jentzsch, Elisa T Helbig, Lena J Lippert, Patricia Tscheak, Marie Luisa Schmidt, Johanna Riege, André Solarek, Christof von Kalle, Chantip Dang-Heine, Henning Gruell, Piotr Kopankiewicz, Norbert Suttorp, Christian Drosten, Harald Bias, Joachim Seybold, Florian Klein, Florian Kurth, Victor Max Corman, Leif Erik Sander, Ben Al-Rim, Lara Bardtke, Jörn Ilmo Beheim-Schwarzbach, Kerstin Behn, Leon Bergfeld, Norma Bethke, Tobias Bleicker, Dana Briesemeister, Sophia Brumhard, Claudia Conrad, Sebastian Dieckmann, Doris Frey, Julie-Anne Gabelich, Philipp Georg, Ute Gläser, Lisbeth Hasler, Andreas Hetey, Anna Luisa Hiller, Alexandra Horn, Claudia Hülso, Luisa Kegel, Willi Koch, Alexander Krannich, Paolo Kroneberg, Michelle Lisy, Petra Mackeldanz, Birgit Maeß, Friederike Münn, Nadine Olk, Christian Peiser, Kai Pohl, Annelie Hermel, Maria Rönnefarth, Carolin Rubisch, Angela Sanchez Rezza, Isabelle Schellenberger, Viktoria Schenkel, Jenny Schlesinger, Sein Schmidt, Georg Schwanitz, Anne-Sophie Sinnigen, Paula Stubbemann, Julia Tesch, Denise Treue, Daniel Wendisch, Saskia Zvorc
Publikováno v:
The Lancet. Respiratory Medicine
Background Heterologous vaccine regimens have been widely discussed as a way to mitigate intermittent supply shortages and to improve immunogenicity and safety of COVID-19 vaccines. We aimed to assess the reactogenicity and immunogenicity of heterolo
Autor:
Dirk Reinhold, Vadim Farztdinov, Yan Yan, Christian Meisel, Henrik Sadlowski, Joachim Kühn, Frank H. Perschel, Mathias Endres, Emrah Düzel, Stefan Vielhaber, Karina Guttek, Alexander Goihl, Morten Venø, Bianca Teegen, Winfried Stöcker, Paula Stubbemann, Florian Kurth, Leif E. Sander, Markus Ralser, Carolin Otto, Simon Streit, Sven Jarius, Klemens Ruprecht, Helena Radbruch, Jørgen Kjems, Michael Mülleder, Frank Heppner, Peter Körtvelyessy
Patients with COVID-19 can have a variety of neurological symptoms, but the pathomechanism of CNS involvement in COVD-19 remains unclear. While routine cerebrospinal fluid (CSF) analyses in patients with neurological manifestations of COVID-19 genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::467db931f1c2b473886d44a8d659f7ab
https://doi.org/10.1101/2022.04.10.22273673
https://doi.org/10.1101/2022.04.10.22273673
Autor:
Ralf-Harto Huebner, Christoph Tabeling, Nils Schallner, Christian Drosten, Terry Jones, Siegbert Rieg, Horst von Bernuth, Uta Merle, Leif E. Sander, Daniel Duerschmied, Barbara Muehlemann, Christine Goffinet, Dietrich August, Victor M. Corman, Norbert Suttorp, JM Doehn, Uwe Koelsch, Olga Staudacher, Achim Lother, Nadine Unterwalder, Charlotte Thibeault, Bengisu Akbil, Daniela Niemeyer, Cédric Hirzel, Alexandra Nieters, Florian Kurth, Christian Nusshag, Tim Meyer, Thomas Doerner, Paula Stubbemann, David Sanchez, Jenny Jansen, Joerg C. Schefold, Valeria Falcone, Thibaud Spinetti, Klaus Warnatz, Christian Meisel, Jan Nikolaus Lieberum, Hartmut Hengel
PurposeSix-19% of critically ill COVID-19 patients display circulating auto-antibodies against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for early identification of IFN-AAB-positive patients for potential subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2f147b460bc5949d7f29fb8ca44cb9
https://doi.org/10.1101/2021.11.12.21266249
https://doi.org/10.1101/2021.11.12.21266249
Autor:
Miriam Stegemann, Alexander Uhrig, Sascha S. Haenel, Pinkus Tober-Lau, Leonie Meiners, Florian Kurth, Janine Wiebach, Martin Witzenrath, Stefan Hippenstiel, Moritz Pfeiffer, Lena J Lippert, Robert Roehle, Tilman Lingscheid, Charlotte Thibeault, Norbert Suttorp, Leif E. Sander, Holger Müller-Redetzky, Christian Drosten, Felix Balzer, Terry Jones, Paula Stubbemann, Laure Bosquillon de Jarcy, Lil Meyer-Arndt, Thomas Zoller, Victor M. Corman, Christof von Kalle, Barbara Mühlemann, Mirja Mittermaier, Elisa T Helbig
Publikováno v:
Infection
Purpose Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk factors ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2bbc27fe62d1715d3a2823bd42e738
http://edoc.mdc-berlin.de/20213/1/20213oa.pdf
http://edoc.mdc-berlin.de/20213/1/20213oa.pdf