Výsledky vyhledávání - "Paula Sotomayor"

Akademický článek

Anti-Inflammatory Chilean Endemic Plants

Autor: Carolina Otero, Carolina Klagges, Bernardo Morales, Paula Sotomayor, Jorge Escobar, Juan A. Fuentes, Adrian A. Moreno, Felipe M. Llancalahuen, Ramiro Arratia-Perez, Felipe Gordillo-Fuenzalida, Michelle Herrera, Jose L. Martínez, Maité Rodríguez-Díaz

Publikováno v: Pharmaceutics, Vol 15, Iss 3, p 897 (2023)

Medicinal plants have been used since prehistoric times and continue to treat several diseases as a fundamental part of the healing process. Inflammation is a condition characterized by redness, pain, and swelling. This process is a hard response by

Externí odkaz: https://doaj.org/article/049663a151514ed0b9eee8e9d6686ed9

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Akademický článek

Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts.

Autor: Kiersten Marie Miles, Mukund Seshadri, Eric Ciamporcero, Remi Adelaiye, Bryan Gillard, Paula Sotomayor, Kristopher Attwood, Li Shen, Dylan Conroy, Frank Kuhnert, Alshad S Lalani, Gavin Thurston, Roberto Pili

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112371 (2014)

The Notch ligand Delta-like 4 (Dll4) is highly expressed in vascular endothelium and has been shown to play a pivotal role in regulating tumor angiogenesis. Blockade of the Dll4-Notch pathway in preclinical cancer models has been associated with non-

Externí odkaz: https://doaj.org/article/2488dbb8c8394714a9609a786cc14fe3

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Akademický článek

Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models.

Autor: Li Shen, Michael Ciesielski, Swathi Ramakrishnan, Kiersten M Miles, Leigh Ellis, Paula Sotomayor, Protul Shrikant, Robert Fenstermaker, Roberto Pili

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30815 (2012)

Immunosuppressive factors such as regulatory T cells (Tregs) limit the efficacy of immunotherapies. Histone deacetylase (HDAC) inhibitors have been reported to have antitumor activity in different malignancies and immunomodulatory effects. Herein, we

Externí odkaz: https://doaj.org/article/0986f9ace105478584e7133947d81eb9

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Akademický článek

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