Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Paula Saklatvala"'
Autor:
Richard P. Marshall, John Martin Pritchard, Josie Morrell, Simon J. F. Macdonald, Seble Lemma, John F. Barrett, Paula Saklatvala, Robert J. Slack, Panayiotis A. Procopiou, Joelle Le, Tim N. Barrett, Ashley Paul Hancock, James E. Rowedder, Matthew H. J. Crawford, Anderson Niall Andrew, Giovanni Vitulli, Colin J. Suckling, Brendan J. Fallon, Steven L. Sollis, Lee R. Thorp
Publikováno v:
Journal of Medicinal Chemistry. 61:8417-8443
A series of 3-aryl(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of (R)-BINAP to a crotonate ester to provide the (S) absolute co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5661106b41cca877b5043e391b8cef81
https://doi.org/10.1021/acs.jmedchem.8b00959
https://doi.org/10.1021/acs.jmedchem.8b00959
Autor:
Panayiotis A, Procopiou, Niall A, Anderson, John, Barrett, Tim N, Barrett, Matthew H J, Crawford, Brendan J, Fallon, Ashley P, Hancock, Joelle, Le, Seble, Lemma, Richard P, Marshall, Josie, Morrell, John M, Pritchard, James E, Rowedder, Paula, Saklatvala, Robert J, Slack, Steven L, Sollis, Colin J, Suckling, Lee R, Thorp, Giovanni, Vitulli, Simon J F, Macdonald
Publikováno v:
Journal of medicinal chemistry. 61(18)
A series of 3-aryl(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of ( R)-BINAP to a crotonate ester to provide the ( S) absolute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea051f2701bfa0f658396c16ce3c8171
https://pubmed.ncbi.nlm.nih.gov/30215258
https://pubmed.ncbi.nlm.nih.gov/30215258
Autor:
Giovanni Vitulli, Albert L. Busza, Laura Dinnewell, Simon P. Campbell, Kashmira Pindoria, Sally-Anne Thompson, Jane Denyer, Diane M. Coe, Marion Lines, Kumar Changani, Paula Saklatvala, Sarah Hotee, Keith Biggadike
Publikováno v:
British Journal of Pharmacology. 169:580-589
Background and Purpose Nasal sensory nerves play an important role in symptoms associated with rhinitis triggered by environmental stimuli. Here, we propose that TRPV1 is pivotal in nasal sensory nerve activation and assess the potential of SB-705498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d618a4f2cb412ee17abd06001a0a2456
https://doi.org/10.1111/bph.12145
https://doi.org/10.1111/bph.12145