Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Paula S. Ludwig"'
Autor:
David K. Meyerholz, Joseph Zabner, Paula S. Ludwig, Jeng-Haur Chen, Leah R. Reznikov, Peter J. Taft, Tanner J. Wallen, Philip H. Karp, Paul B. McCray, Sarah E. Ernst, Nicholas D. Gansemer, Michael V. Rector, George A. Nelson, Mahmoud M.Abou Alaiwa, Emma E. Hornick, Randall S. Prather, Eugene H. Chang, Ryan J. Adam, Alejandro A. Pezzulo, David A. Stoltz, Drake C. Bouzek, Lynda S. Ostedgaard, Michael J. Welsh, Tatiana Rokhlina, Melissa Samuel, James D. McMenimen, Katrina L. Bogan, Mark J. Hoegger, Christine L. Wohlford-Lenane, Eric A. Hoffman
Publikováno v:
Journal of Clinical Investigation. 123:2685-2693
Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people with CF, including exocrine pancreatic destruction, focal biliary cirrhosis, micro-gallbladder, vas deferens loss, airway disease, and meconium ileus. Where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dceed20800233d396882605f772325
https://doi.org/10.1172/jci68867
https://doi.org/10.1172/jci68867
Autor:
Maisam Abu-El-Haija, Peter J. Taft, Aliye Uc, Alejandro A. Pezzulo, Michelle Griffin, Marwa Abu-El-Haija, David K. Meyerholz, Lynda S. Ostedgaard, Michael J. Welsh, Paula S. Ludwig, Radhamma L. Giriyappa, Xiaoxiao Tang, David A. Stoltz
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G961-G968
The pancreas, liver, and gallbladder are commonly involved in cystic fibrosis (CF), and acidic, dehydrated, and protein-rich secretions are characteristic findings. Pancreatic function studies in humans have been done by sampling the jejunal fluid. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec70a9bf4ce9a2f4ad8259b530dfbf80
https://doi.org/10.1152/ajpgi.00030.2012
https://doi.org/10.1152/ajpgi.00030.2012
Autor:
Aliye Uc, Jianrong Yao, Leah R. Reznikov, David A. Stoltz, Alejandro A. Pezzulo, Peter J. Taft, Alicia K. Olivier, Michelle Griffin, Michael V. Rector, Maisam Abu-El-Haija, Paula S. Ludwig, David K. Meyerholz, Katherine M. Buchanan, Marwa Abu-El-Haija, Michael J. Welsh, Katie Larson Ode, Andrew W. Norris, John F. Engelhardt, Emma E. Hornick, Mark J. Hoegger, Nicholas D. Gansemer, Oriana G. Vanegas Calderón, Lynda S. Ostedgaard
Diabetes is a common and significant co-morbidity in cystic fibrosis (CF). The pathogenesis of cystic fibrosis related diabetes (CFRD) is incompletely understood. Because exocrine pancreatic disease is similar between humans and pigs with CF, the CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca200153524a0c60236752a9d6ba8d3d
https://europepmc.org/articles/PMC4346161/
https://europepmc.org/articles/PMC4346161/
Autor:
David A. Stoltz, Peter J. Taft, Alejandro A. Pezzulo, Maisam Abu-El-Haija, A. Uc, Michael J. Welsh, David K. Meyerholz, Marwa Abu-El-Haija, Michelle Griffin, Paula S. Ludwig
Publikováno v:
Journal of Cystic Fibrosis. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9211d5524a7346e0afae5a931668214
Autor:
Alejandro A. Pezzulo, Michael J. Welsh, Paul B. McCray, Lynda S. Ostedgaard, Peter J. Taft, Philip H. Karp, Christine L. Wohlford-Lenane, Aliye Uc, Cassie L. Dohrn, Sarah E. Ernst, Paula S. Ludwig, Michael V. Rector, Leah R. Reznikov, Yuping Zhang, Melissa Samuel, Sandra S. Richter, Tatiana Rokhlina, Mark P. Rogan, Jeng-Haur Chen, David A. Stoltz, David K. Meyerholz, Emma E. Hornick, Joseph Zabner, Randall S. Prather, Robert A. Hanfland, Boulos Nassar, Greg J. Davis, Joel Shilyansky
Publikováno v:
Science Translational Medicine. 3
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. The most common CF-associated mutation is ΔF508, which deletes a phenylalan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec0e9e2507d1db1d92fe6633b2d4904
https://doi.org/10.1126/scitranslmed.3001868
https://doi.org/10.1126/scitranslmed.3001868
Autor:
Joel Shilyansky, Michael J. Welsh, Alejandro A. Pezzulo, Cassie L. Dohrn, George A. Nelson, Mira Estin, Emma E. Hornick, Kim A. Brogden, Aliye Uc, Eugene H. Chang, Greg J. Davis, Peter J. Taft, Timothy D. Starner, Chris Wohlford-Lenane, Robert A. Hanfland, David K. Meyerholz, Mark P. Rogan, Joseph Zabner, Sandra S. Richter, Lynda S. Ostedgaard, David A. Stoltz, Shyam Ramachandran, Melissa Samuel, Janice L. Launspach, Alexander R. Horswill, Randall S. Prather, Tatiana Rokhlina, Philip H. Karp, Paula S. Ludwig, Paul B. McCray, Jennifer A. Bartlett
Publikováno v:
Science Translational Medicine. 2
Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). Understanding the pathogenesis of this disease has been hindered, however, by the lack of an animal model with characteristic features of CF. To overcome this problem, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ae27f4f18ce34a33fb0f1ee1d757d0
https://doi.org/10.1126/scitranslmed.3000928
https://doi.org/10.1126/scitranslmed.3000928
Autor:
Eric W. Dickson, Gerene M. Denning, Christopher P. Hogrefe, Lynn L. Stoll, Paula S. Ludwig, Laynez W. Ackermann
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 294(1)
Exercise increases serum opioid levels and improves cardiovascular health. Here we tested the hypothesis that opioids contribute to the acute cardioprotective effects of exercise using a rat model of exercise-induced cardioprotection. For the standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed1b930e2964959e841e971bade5339
https://pubmed.ncbi.nlm.nih.gov/17951371
https://pubmed.ncbi.nlm.nih.gov/17951371
Autor:
Eric W. Dickson, Laynez W. Ackermann, Paula S. Ludwig, Christopher T. Buresh, Gerene M. Denning
Publikováno v:
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 13(8)
Background: Acute myocardial ischemia is an important cause of morbidity and mortality worldwide. The heart and other organs can be rendered more resistant to the deleterious effects of ischemia through a variety of preconditioning strategies, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004bc54a90c9ae770185003f2064ff93
https://pubmed.ncbi.nlm.nih.gov/16766738
https://pubmed.ncbi.nlm.nih.gov/16766738
Autor:
Bo Wu, David S. Warner, Robert D. Pearlstein, Seiji Takaoka, Paula S. Ludwig, Ann D. Brinkhous, Franklin Dexter
Publikováno v:
Anesthesiology. 84(6)
Background Barbiturates have previously been demonstrated to reduce focal cerebral ischemic brain damage. However, the dose of drug required to elicit maximal neuroprotection has not been defined. The authors' hypothesized that doses of pentobarbital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4570f9456820355d33179eba6610f299
https://pubmed.ncbi.nlm.nih.gov/8968212
https://pubmed.ncbi.nlm.nih.gov/8968212
Publikováno v:
Stroke. 26(4)
Background and Purpose Although acute hyperglycemia is known to increase global ischemic brain damage, the duration of ischemia necessary to elicit such an effect is unknown. Accordingly, an experiment was performed to determine the duration of foreb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbf44d66408b22e8314e7bb03a69eee
https://pubmed.ncbi.nlm.nih.gov/7709414
https://pubmed.ncbi.nlm.nih.gov/7709414