Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paula S. Leppert"'
Autor:
Paula S. Leppert, Joseph A. Fix
Publikováno v:
Journal of Pharmaceutical Sciences. 83:976-981
The ability to predict in vivo oral absorption potential based on ex vivo screening in an everted intestinal ring model was examined. In vitro drug accumulation in cross sectional rings of everted rat jejunum was determined with 12 compounds whose in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508a2da91c3d01143ae11650a8350b0
https://doi.org/10.1002/jps.2600830712
https://doi.org/10.1002/jps.2600830712
Autor:
Margot Cortese, Robyn Cargill, Joseph A. Fix, Karen Engle, Lori Coffman, Paula S. Leppert, Colette Krupco, Leilani Cammack
Publikováno v:
Journal of Biomedical Materials Research. 28:713-722
Rats, dogs, sheep, and cattle were implanted subcutaneously with stainless-steel tissue cages. Bolus injections of cefoxitin and ivermectin were administered to the interiors of the tissue cages 11, 32, and 60 days after implantation to simulate puls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268a183b769bf9d8b6a62aa82c21c7e8
https://doi.org/10.1002/jbm.820280608
https://doi.org/10.1002/jbm.820280608
Publikováno v:
Pharmaceutical Research. :384-387
Short-chain alkyl esters of L-dopa were administered to rats and mice via oral and rectal routes. Plasma L-dopa esters and L-dopa were determined in the systemic and portal circulation by HPLC. A comparison of isopropyl, butyl, and 4-hydroxybutyl est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb43fe6e6bf195880f7a8f782fe8257
https://doi.org/10.1023/a:1015823523388
https://doi.org/10.1023/a:1015823523388
Autor:
Paula S. Leppert, Joseph A. Fix
Publikováno v:
Biomaterials. 11(1)
A subcutaneous tissue cage implant system was examined for its utility in evaluating the subcutaneous response to slow release of potentially irritating materials from implanted devices. The degree of the inflammatory response was measured by the tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aa67a7c69aacff115d6c121115b205
https://pubmed.ncbi.nlm.nih.gov/2405917
https://pubmed.ncbi.nlm.nih.gov/2405917
Publikováno v:
Journal of Pharmaceutical Sciences. 72:1134-1137
The rectal absorption of gentamicin sulfate in rats, both in the presence and absence of sodium salicylate, was facilitated by the use of high ionic strength aqueous formulations. The relative order of effectiveness in promoting gentamicin absorption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3c8e6d34f1548c6593b186ceb156ac
https://doi.org/10.1002/jps.2600721006
https://doi.org/10.1002/jps.2600721006
Autor:
Joseph A. Fix, Paula S. Leppert
Publikováno v:
Journal of Controlled Release. 4:87-95
In vitro erosion of poly(ortho ester) devices labelled with [14C] 1, 6-hexanediol was examined in canine gastric juice, USP-simulated gastric juice and pH 7 phosphate buffer. Two percent phthalic anhydride effectively minimized major differences in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85280a023f2d4679de606bdfaca80e58
https://doi.org/10.1016/0168-3659(86)90044-1
https://doi.org/10.1016/0168-3659(86)90044-1
Publikováno v:
Journal of pharmaceutical sciences. 72(6)
The involvement of active sodium transport in the rectal absorption of gentamicin sulfate was examined in rats, employing aqueous microenemas of known total ionic strength (mu) in the presence or absence of absorption-promoting adjuvants. Rectal gent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3988344c679d5bcfaeb5c59b2a2fa9
https://pubmed.ncbi.nlm.nih.gov/6875833
https://pubmed.ncbi.nlm.nih.gov/6875833
Publikováno v:
The Journal of pharmacy and pharmacology. 36(4)
The ability of phenothiazines to enhance the rectal absorption of sodium cefoxitin and gentamicin sulphate from aqueous formulations was examined in rats. In the absence of absorption―promoting adjuvants, sodium cefoxitin and gentamicin sulphate bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5a9db54c81892abf5067f0bb0e9ad9
https://pubmed.ncbi.nlm.nih.gov/6144788
https://pubmed.ncbi.nlm.nih.gov/6144788