Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients

Autor: Juliana de A. S. Gomes, Fernanda F. de Araújo, Daniele M. Vitelli-Avelar, Renato Sathler-Avelar, Paula S. Lage, Ana P. B. Wendling, Isabela N. P. C. do Vale, João C. P. Dias, Silvana M. Elói-Santos, Andréa Teixeira-Carvalho, Olindo A. Martins-Filho

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

The systems biology approach has become an innovative tool when it comes to shedding light on the complex immune response underlying the development/maintenance of distinct clinical forms of Chagas disease. The goal of this study was to describe an i

Externí odkaz: https://doaj.org/article/f145804cf4b14d4dad9c8691df5cdb87

Identification of proteins in promastigote and amastigote-like Leishmania using an immunoproteomic approach.

Autor: Vinicio T S Coelho, Jamil S Oliveira, Diogo G Valadares, Miguel A Chávez-Fumagalli, Mariana C Duarte, Paula S Lage, Manuel Soto, Marcelo M Santoro, Carlos A P Tavares, Ana Paula Fernandes, Eduardo A F Coelho

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 1, p e1430 (2012)

BackgroundThe present study aims to identify antigens in protein extracts of promastigote and amastigote-like Leishmania (Leishmania) chagasi syn. L. (L.) infantum recognized by antibodies present in the sera of dogs with asymptomatic and symptomatic

Externí odkaz: https://doaj.org/article/dc416b86cf8d46cc80acdda37c4f26e6

An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis

Autor: Eduardo A.F. Coelho, Lourena E. Costa, Manuel Soto, Vívian T. Martins, Leonardo Lima Fuscaldi, Mariana C. Duarte, Paula S. Lage, Rachel Oliveira Castilho, Carlos Alberto Pereira Tavares, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Miguel A. Chávez-Fumagalli, Tatiana G. Ribeiro, André Augusto Gomes Faraco, Juçara R. Franca, Mara Lívia dos Santos

Publikováno v: International Journal of Nanomedicine
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB), containing chitosan and chondroitin sulfate molecules, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99a97dddc788d21d34987674e00af60
http://europepmc.org/articles/PMC4242406

Strychnos pseudoquinaand Its Purified Compounds Present an EffectiveIn VitroAntileishmanial Activity

Autor: Lourena E. Costa, Tatiana G. Ribeiro, Miguel Angel Chávez Fumagalli, Mariana C. Duarte, José Dias de Souza Filho, Vívian T. Martins, João Paulo Viana Leite, Paula S. Lage, Eduardo A.F. Coelho, Diogo G. Valadares, Pedro H.R. Andrade, Amanda de Santana Lopes, Daniela P. Lage, Rodrigo Maia de Pádua, Carlos Alberto Pereira Tavares

Publikováno v: LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV
Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
Evidence-based Complementary and Alternative Medicine : eCAM

The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity ofStrychnos pseudoquinaSt. Hil. was investigated and pure compounds tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dd3310b103ea31cc3afdf27accbac4
https://doi.org/10.1155/2013/304354

Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum

Autor: Andre G. Tempone, Carlos Alberto Pereira Tavares, Simone Odília Antunes Fernandes, Miguel A. Chávez-Fumagalli, Juliana T. Mesquita, Valbert Nascimento Cardoso, Manuel Soto, João Paulo Viana Leite, Eduardo A.F. Coelho, Laís M. Mata, Paula S. Lage

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV

© 2015, Springer-Verlag Berlin Heidelberg. The present study aimed to investigate the in vitro antileishmanial activity of strychnobiflavone flavonoid against Leishmania infantum, as well as its mechanism of action, and evaluate the ex vivo biodistr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b06e16d62903bf976103231a6a79f77
http://hdl.handle.net/10261/133194