Výsledky vyhledávání - "Paula S. Hochman"

Recombinant ST2 boosts hepatic Th2 response in vivo

Autor: Margot Brickelmaier, Kevin Gilbride, Aldo Amatucci, Paula S. Hochman, Tatiana Novobrantseva, Alexander Ibraghimov

Publikováno v: Journal of Leukocyte Biology. 82:124-132

Excessive scarring or fibrosis is a common feature of a wide spectrum of diseases characterized by an exaggerated Th2 response. The TLR/IL-1 receptor (IL-1R)-related protein ST2 is expressed in a membrane-bound form selectively by Th2 cells and was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8ef0ee45b5a96d18678c51b38d54a4
https://doi.org/10.1189/jlb.1006625

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Attenuated liver fibrosis in the absence of B cells

Autor: Paula S. Hochman, Mark J. Shlomchik, Ian Brenner, Victor Koteliansky, Gerard R. Majeau, Aldo Amatucci, Tatiana Novobrantseva, Sophia Kogan, Alexander Ibraghimov, Stefano Casola

Publikováno v: Journal of Clinical Investigation. 115:3072-3082

Analysis of mononuclear cells in the adult mouse liver revealed that B cells represent as much as half of the intrahepatic lymphocyte population. Intrahepatic B cells (IHB cells) are phenotypically similar to splenic B2 cells but express lower levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c05a05806578cc2e359d1e2f8488c30
https://doi.org/10.1172/jci24798

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Protection against Progressive Leishmaniasis by IFN-β

Autor: Paula S. Hochman, Alexandra Wandersee-Steinhäuser, Jochen Mattner, Martin Röllinghoff, Gerard R. Majeau, Andreas Pahl, Christian Bogdan

Publikováno v: The Journal of Immunology. 172:7574-7582

Type I IFNs (IFN-αβ) exert potent antiviral and immunoregulatory activities during viral infections, but their role in bacterial or protozoan infections is poorly understood. In this study, we demonstrate that the application of low, but not of hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b73ccd2c526abb7ad8d048c944d8ac
https://doi.org/10.4049/jimmunol.172.12.7574

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Expression, purification, and characterization of rat interferon-β, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters

Publikováno v: Protein Expression and Purification. 34:229-242

To identify potential new clinical uses and routes of administration for human interferon-beta-1a (IFN-beta-1a), we have developed an expression and purification procedure for the preparation of highly purified rat interferon-beta (IFN-beta) suitable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681c84dd263ebd5ab5bb92feaf711c21
https://doi.org/10.1016/j.pep.2003.11.004

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Comparison of Gene Expression Patterns Induced by Treatment of Human Umbilical Vein Endothelial Cells with IFN-α2b vs. IFN-β1a: Understanding the Functional Relationship Between Distinct Type I Interferons That Act Through a Common Receptor

Autor: Adrian Whitty, Paula S. Hochman, Alexander V. Lukashin, John Peyman, Margot Brickelmaier, Gerard R. Majeau, Antonio J. da Silva

Publikováno v: Journal of Interferon & Cytokine Research. 22:173-188

We analyzed whether interferon-alpha 2b (IFN-alpha 2b) and IFN-beta 1a engage their common receptor to generate activated receptor complexes possessing distinct signaling properties. Human vascular endothelial cells (HUVEC) are 100-1000-fold more sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f4382cce1ea8971ae62cb49d20662a
https://doi.org/10.1089/107999002753536149

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Essential Role of Lymph Nodes in Contact Hypersensitivity Revealed in Lymphotoxin-α–Deficient Mice

Autor: David D. Chaplin, Yang Xin Fu, Paul D. Rennert, Richard A. Flavell, Jeffrey L. Browning, Sundararajan Jayaraman, Paula S. Hochman

Publikováno v: The Journal of Experimental Medicine

Lymph nodes (LNs) are important sentinal organs, populated by circulating lymphocytes and antigen-bearing cells exiting the tissue beds. Although cellular and humoral immune responses are induced in LNs by antigenic challenge, it is not known if LNs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0976422a5cbf768eff13ef7d5ec95d52
https://doi.org/10.1084/jem.193.11.1227

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The structure of human interferon- ? : implications for activity

Autor: Adrian Whitty, Paula S. Hochman, Laura Runkel, Michael Karpusas

Publikováno v: Cellular and Molecular Life Sciences (CMLS). 54:1203-1216

Interferons (IFNs) are potent extracellular protein mediators of host defence and homoeostasis. This article reviews the structure of human IFN-beta (HuIFN-beta), in particular in relation to its activity. The recently determined crystal structure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f50ff6aa93e39c695e9cf7cbaff2ac
https://doi.org/10.1007/s000180050248

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Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization

Autor: Jeffrey L. Browning, Paula S. Hochman, Paul D. Rennert

Publikováno v: International Immunology. 9:1627-1639

Lymphotoxin (LT) provides a critical signal for the genesis of lymph nodes (LN) in mice. Here we show that mice treated in utero with LT beta-R-Ig, which binds to the membrane LT alpha 1 beta 2 heterotrimer, lacked most LN, yet retained a set of muco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0fb1d5695cda995c5fc48dd367492f
https://doi.org/10.1093/intimm/9.11.1627

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