Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Paula S. Farag"'
1
New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile
Autor: Mohamed H. Hekal, Paula S. Farag, Magdy M. Hemdan, Amira A. El-Sayed, Aya I. Hassaballah, Wael M. El-Sayed
Publikováno v: RSC Advances. 13:15810-15825
Compound 19 arrested the MCF-7 cells at the G2/M phase probably through inhibition of CDK1 and elicited apoptosis. It did not violate Lipinski's rule of five and has a low blood brain barrier penetration and high intestinal absorption.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a411aee337c122653dba95a707c3a74a
https://doi.org/10.1039/d3ra02716c
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2
The Reformatsky analogous reaction for the synthesis of novel β-thioxoesters via using aroyl isothiocyanates under solvent-free ball milling and conventional conditions
Autor: Paula S. Farag, Magdy M. Hemdan, Aya I. Hassaballah
Publikováno v: RSC Advances. 12:10204-10208
The Reformatsky analogous reaction between aroyl isothiocyanates and α-haloesters using metallic zinc to form β-thioxoesters via ball milling and conventional techniques.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec156772129bba47bbfbf7a8e164f651
https://doi.org/10.1039/d2ra01154a
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3
The Reformatsky analogous reaction for the synthesis of novel β-thioxoesters
Autor: Paula S, Farag, Magdy M, Hemdan, Aya I, Hassaballah
Publikováno v: RSC advances. 12(17)
The classical Reformatsky reaction, initially described in 1887, is considered one of the most useful ways of forming C-C bonds. The target of this work includes improving the Reformatsky reaction between aroyl isothiocyanates and α-haloesters using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebb09eb39e855f8e930918196acd6385
https://pubmed.ncbi.nlm.nih.gov/35424970
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4
Annulated pyrazole derivatives as a novel class of urokinase (uPA) inhibitors: Green synthesis, anticancer activity, DNA-damage evaluation, and molecular modelling study
Autor: Paula S. Farag, Asmaa M. AboulMagd, Magdy M. Hemdan, Aya I. Hassaballah
Publikováno v: Bioorganic Chemistry. 130:106231
Different series of annulated pyrazole derivatives were designed, synthesized via both green and traditional methods, and structurally characterized. In vitro uPA evaluation, antiproliferative activities and DNA binding damage was studied in this wor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8f2e80d67a257a15bafad2fd29d0b8
https://doi.org/10.1016/j.bioorg.2022.106231
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6
Design, microwave assisted synthesis, and molecular modeling study of some new 1,3,4-thiadiazole derivatives as potent anticancer agents and potential VEGFR-2 inhibitors
Autor: Saad R. Atta-Allah, Paula S. Farag, Asmaa M. AboulMagd
Publikováno v: Bioorganic Chemistry. 112:104923
A green and efficient method was developed for the synthesis of 1,3,4-thiadiazole based compounds under microwave (MW) activation. The nucleophile N-(5-amino-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide (3) was synthesized and reacted with different
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568dace14b1957ce0f5291127942c914
https://doi.org/10.1016/j.bioorg.2021.104923
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