Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paula S. Espino"'
Autor:
Shihua He, James R. Davie, Shannon Healy, Bojan Drobic, Soma Mandal, Paula S. Espino, Beatriz Pérez-Cadahía
Publikováno v:
Journal of Biological Chemistry. 286:42-49
Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b403ca11bbbc2cb1a0968a45692cdb3
https://doi.org/10.1074/jbc.m110.156687
https://doi.org/10.1074/jbc.m110.156687
Autor:
Katherine L. Dunn, Landon Wark, Geneviève P. Delcuve, Shihua He, Jian-Min Sun, Paula S. Espino, Sabine Mai, James R. Davie, Sophie N. Davie, Hou Yu Chen, Dilshad H. Khan, Sumin Lu, Cheryl Peltier, Beatriz Pérez-Cadahía, Bojan Drobic
Publikováno v:
Advances in Enzyme Regulation. 50:135-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb269e5b9206c93837bd05a79ad4957
https://doi.org/10.1016/j.advenzreg.2009.10.008
https://doi.org/10.1016/j.advenzreg.2009.10.008
Publikováno v:
International Journal of Cancer. 124:562-567
Activating mutations in K-Ras occur in most pancreatic cancers. We investigated whether genetic changes (K-Ras mutations) in human pancreatic cancer cell lines altered genomic instability and epigenetic events responding to Ras-mitogen activated prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877fd147604e66d7edccb11acbaccda8
https://doi.org/10.1002/ijc.23959
https://doi.org/10.1002/ijc.23959
Autor:
Xuemei Wang, Paula S. Espino, Anoushe SekhavatA. Sekhavat, Shihua He, Katherine L. Dunn, Susan Pritchard, Jenny Yu, Hou Yu Chen, Jian-Min Sun, James R. Davie, Bojan Drobic, Lin Li
Publikováno v:
Advances in Enzyme Regulation. 48:189-208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391d990a5119e4c299d16c0da84bc3a7
https://doi.org/10.1016/j.advenzreg.2007.11.016
https://doi.org/10.1016/j.advenzreg.2007.11.016
Publikováno v:
Nucleic Acids Research
Histone modifications and variants have key roles in the activation and silencing of genes. Phosphorylation of histone H3 at serine 10 and serine 28 is involved in transcriptional activation of genes responding to stress or mitogen-stimulated signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08b8b837b9ba6c8bc6f8eb764597a55
https://doi.org/10.1093/nar/gkm737
https://doi.org/10.1093/nar/gkm737
Autor:
Lin Li, Paula S. Espino, Bojan Drobic, Shihua He, Jenny Yu, Jian-Min Sun, Hou Yu Chen, James R. Davie, Katherine L. Dunn, Susan Pritchard
Publikováno v:
Journal of Cellular Biochemistry. 104:2004-2015
Nuclear morphometric descriptors such as nuclear size, shape, DNA content and chromatin organization are used by pathologists as diagnostic markers for cancer. However, our knowledge of events resulting in changes in nuclear shape and chromatin organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4d18362fc58f79403566ab8c5dfadc
https://doi.org/10.1002/jcb.21485
https://doi.org/10.1002/jcb.21485
Publikováno v:
Cancer Research. 66:4610-4616
Histone H3 phosphorylation is a downstream response to activation of the Ras/mitogen-activated protein kinase (MAPK) pathway. This modification is thought to have a role in chromatin remodeling and in the initiation of gene transcription. In MCF-7 br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9720e45d4054b505581c4b979b2a6139
https://doi.org/10.1158/0008-5472.can-05-4251
https://doi.org/10.1158/0008-5472.can-05-4251
Publikováno v:
Journal of Biological Chemistry. 281:5532-5538
Tissue transglutaminase 2 (TG2) has recently been shown to have intrinsic serine/threonine kinase activity. Since histones are known to be cross-linked by TG2, we investigated whether histones are also substrates for TG2 kinase activity. TG2 was able
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8795b04b1bb701934c9658effe9e188f
https://doi.org/10.1074/jbc.m506864200
https://doi.org/10.1074/jbc.m506864200
Publikováno v:
Biochemistry and Cell Biology. 83:1-14
Stimulation of the Ras-mitogen-activated protein kinase (MAPK) signal transduction pathway results in a multitude of events including expression of the immediate-early genes, c-fos and c-myc. Downstream targets of this stimulated pathway are the mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e843d56c5040e1702dcbc9a5f382d23e
https://doi.org/10.1139/o04-121
https://doi.org/10.1139/o04-121
Publikováno v:
Cancer Research. 64:9076-9079
Activation of the Ras-Raf-mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase-ERK signal transduction pathway or the SAPK2/p38 pathway results in the activation of mitogen- and stress-activated protein kinase 1 (MSK1). This a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9194719679a00adff0afc8d0261aee32
https://doi.org/10.1158/0008-5472.can-04-2369
https://doi.org/10.1158/0008-5472.can-04-2369