The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

Autor: Juliana Escher Toller-Kawahisa, Carlos Hiroji Hiroki, Camila Meirelles de Souza Silva, Daniele Carvalho Nascimento, Gabriel Azevedo Públio, Timna Varela Martins, Luis Eduardo Alves Damasceno, Flávio Protásio Veras, Paula Ramos Viacava, Fábio Yuji Sukesada, Emily Anne Day, Alessia Zotta, Tristram Alexander Jasper Ryan, Rodrigo Moreira da Silva, Thiago Mattar Cunha, Norberto Peporine Lopes, Fernando de Queiroz Cunha, Luke Anthony John O’Neill, José Carlos Alves-Filho

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Neutrophils rely predominantly on glycolytic metabolism for their biological functions, including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) is a glycolytic enzyme known to be involved in metabolic reprogram

Externí odkaz: https://doaj.org/article/e9048a7d82b3436bbdf0ceaf5f09651b

Importância do metabolismo glicolítico na regulação da produção de adenosina e IL-10 em macrófagos: papel do metabólito frutose-1,6-bisfosfato e da enzima PKM2

Autor: Paula Ramos Viacava

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Evidências crescentes de que os processos metabólicos desempenham um papel no controle das funções efetoras imunes, nos fazem compreender melhor os papéis e funções das vias metabólicas nas respostas imunes, assim possibilitar o surgimento de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a402dba96c409c6070e6c33796db6a
https://doi.org/10.11606/t.17.2021.tde-04082021-143824

Sepsis expands a CD39 + plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Autor: Paulo Henrique Melo, Luisa Menezes-Silva, Fernando Q. Cunha, Marcos C. Borges, Bernhard Ryffel, Daniel Zoppi, Ícaro Maia Santos de Castro, Juliana E Toller-Kawahisa, Diego B. Caetite, Paula Ramos Viacava, Antonio Edson Rocha Oliveira, Raphael S. Peres, Helder I. Nakaya, Daniele C. Nascimento, Joel Linden, Thiago M. Cunha, Dario S. Zamboni, Gilles Kauffenstein, José C. Alves-Filho, Raphael Gomes Ferreira, Valérie F. J. Quesniaux, Denise Morais da Fonseca, Flávio P. Veras, Paula B. Donate, Annie R. Piñeros, Jonas Augusto Rizzato Paschoal, Marina Alves Damaceno

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Immunity
Immunity, Elsevier, 2021, 54 (9), pp.2024-2041.e8. ⟨10.1016/j.immuni.2021.08.005⟩

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections. We utili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478195521c4469e00f8cd9a0d748fe20

Sepsis expands a CD39

Autor: Daniele Carvalho, Nascimento, Paula Ramos, Viacava, Raphael Gomes, Ferreira, Marina Alves, Damaceno, Annie Rocío, Piñeros, Paulo Henrique, Melo, Paula Barbim, Donate, Juliana Escher, Toller-Kawahisa, Daniel, Zoppi, Flávio Protásio, Veras, Raphael Sanches, Peres, Luísa, Menezes-Silva, Diego, Caetité, Antonio Edson Rocha, Oliveira, Ícaro Maia Santos, Castro, Gilles, Kauffenstein, Helder Imoto, Nakaya, Marcos Carvalho, Borges, Dario Simões, Zamboni, Denise Morais, Fonseca, Jonas Augusto Rizzato, Paschoal, Thiago Mattar, Cunha, Valerie, Quesniaux, Joel, Linden, Fernando Queíroz, Cunha, Bernhard, Ryffel, José Carlos, Alves-Filho

Publikováno v: Immunity. 54(9)

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections. We utili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0bc0545e642372f3de80b80e017062f
https://pubmed.ncbi.nlm.nih.gov/34473957

MEK5/ERK5 signaling mediates IL‐4‐induced M2 macrophage differentiation through regulation of c‐Myc expression

Autor: André L. L. Saraiva, Emanuele Giurisato, Thiago M. Cunha, Marc LeBert, Priscilla Aparecida Tartari Pereira, Cathy Tournier, Douglas Silva Prado, Paula Ramos Viacava, Daniele C. Nascimento, Juliana E Toller-Kawahisa, João Paulo Mesquita Luiz, Fernando Q. Cunha, Bernhard Ryffel, José C. Alves-Filho, Valérie F. J. Quesniaux

Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2020, 108 (4), pp.1215-1223. ⟨10.1002/JLB.1MA0520-016R⟩
Tournier, C 2020, ' MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression ', Journal of leukocyte biology|J Leukoc Biol . https://doi.org/10.1002/JLB.1MA0520-016R
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

International audience; Macrophages play a critical role in the regulation of immune responses. They are highly plastic cells, responding to diverse environmental stimuli to acquire different functional phenotypes. Intracellular signaling through mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66f133d679b1b8f077a57a0cb98e77f
https://hal.archives-ouvertes.fr/hal-03008402