Zobrazeno 1 - 5 of 5 pro vyhledávání: '"Paula Pousinha"'
1
Akademický článek
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice
Autor: Marta Prieto, Alessandra Folci, Gwénola Poupon, Sara Schiavi, Valeria Buzzelli, Marie Pronot, Urielle François, Paula Pousinha, Norma Lattuada, Sophie Abelanet, Sara Castagnola, Magda Chafai, Anouar Khayachi, Carole Gwizdek, Frédéric Brau, Emmanuel Deval, Maura Francolini, Barbara Bardoni, Yann Humeau, Viviana Trezza, Stéphane Martin
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The R138Q mutation in the Fragile X Mental Retardation 1 (FMR1) gene has been associated with Fragile X syndrome (FXS). Here, the authors present a Fmr1 R138Q Knock-In mouse model and show that R138Q mutation results in impaired long-term potentiatio
Externí odkaz: https://doaj.org/article/1f547051b6104cb2ae2a8dd5047148af
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2
Akademický článek
Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse
Autor: Marie-Charlotte Allichon, Vanesa Ortiz, Paula Pousinha, Andry Andrianarivelo, Anna Petitbon, Nicolas Heck, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte
Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Drug addiction is defined as a compulsive pattern of drug-seeking- and taking- behavior, with recurrent episodes of abstinence and relapse, and a loss of control despite negative consequences. Addictive drugs promote reinforcement by increasing dopam
Externí odkaz: https://doaj.org/article/14e406d843c143d582144e687b4ea306
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3
Akademický článek
Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model
Autor: Georgia-Ioanna Kartalou, Ana Rita Salgueiro-Pereira, Thomas Endres, Angelina Lesnikova, Plinio Casarotto, Paula Pousinha, Kevin Delanoe, Elke Edelmann, Eero Castrén, Kurt Gottmann, Hélène Marie, Volkmar Lessmann
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 23, p 8957 (2020)
Therapeutic approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD-related syna
Externí odkaz: https://doaj.org/article/0b66fe9c2ad341a78d6a37042b170cda
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