Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Paula N. Friedman"'
Autor:
Paula N. Friedman, Mohammed Shaazuddin, Li Gong, Robert L. Grossman, Arthur F. Harralson, Teri E. Klein, Norman H. Lee, Doriane C. Miller, Edith A. Nutescu, Travis J. O'Brien, Peter H. O'Donnell, Kevin J. O'Leary, Matthew Tuck, David O. Meltzer, Minoli A. Perera
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 3, Pp 209-217 (2019)
The majority of pharmacogenomic (PGx) studies have been conducted on European ancestry populations, thereby excluding minority populations and impeding the discovery and translation of African American–specific genetic variation into precision medi
Externí odkaz:
https://doaj.org/article/958635f1e72f454ab41a5ad58c2d1442
Autor:
Thomas Chen, Peter H. O’Donnell, Merisa Middlestadt, Gregory W. Ruhnke, Keith Danahey, Xander M.R. van Wijk, Anish Choksi, Randall Knoebel, Seth Hartman, Kiang-Teck Jerry Yeo, Paula N. Friedman, Mark J. Ratain, Edith A. Nutescu, Kevin J. O’Leary, Minoli A. Perera, David O. Meltzer
Publikováno v:
Pharmacogenetics and Genomics. 33:19-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c4460655fb0b0d9b0abca278fe78e0a
https://doi.org/10.1097/fpc.0000000000000487
https://doi.org/10.1097/fpc.0000000000000487
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
1000 SNPs with greatest statistical association with cumulative docetaxel dose at grade 3+ neuropathy in CALGB 90401 discovery GWAS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3a32f960da8ef5ef60d314598d5e4a
https://doi.org/10.1158/1078-0432.22468622
https://doi.org/10.1158/1078-0432.22468622
Autor:
Deanna L. Kroetz, Kouros Owzar, Alan P. Venook, Mark J. Ratain, Federico Innocenti, Howard L. McLeod, William Kevin Kelly, Susan Halabi, Hope S. Rugo, James N. Atkins, Heinz-Josef Lenz, Howard S. Hochster, Donna Niedzwiecki, Michiaki Kubo, Yukihide Momozawa, Paula N. Friedman, Fei Shen, Bryan P. Schneider, Bert H. O’Neil, Chen Jiang, Flora Mulkey, Megan Li
Purpose: Bevacizumab is a VEGF-specific angiogenesis inhibitor indicated as an adjunct to chemotherapy for the treatment of multiple cancers. Hypertension is commonly observed during bevacizumab treatment, and high-grade toxicity can limit therapy or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e99a814a31f502415951927ae4a4f7e
https://doi.org/10.1158/1078-0432.c.6525887
https://doi.org/10.1158/1078-0432.c.6525887
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
Peripheral neuronal cells (Peri.4U) treated with docetaxel were found to have a significant decrease in sensitivity for A) mean process lengths but not for B) mean outgrowth intensity or C) relative straightness as measured after 24 hours post-drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01213f721229f9327ba93b99118e0ff2
https://doi.org/10.1158/1078-0432.22468634.v1
https://doi.org/10.1158/1078-0432.22468634.v1
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
Number of patients who experienced neuropathy, completed treatment without neuropathy and discontinued treatment early without having neuropathy while on study and within each range of cumulative treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf9f01f48f440b188d22bf78ee4e14a
https://doi.org/10.1158/1078-0432.22468625.v1
https://doi.org/10.1158/1078-0432.22468625.v1
Autor:
Deanna L. Kroetz, Kouros Owzar, Alan P. Venook, Mark J. Ratain, Federico Innocenti, Howard L. McLeod, William Kevin Kelly, Susan Halabi, Hope S. Rugo, James N. Atkins, Heinz-Josef Lenz, Howard S. Hochster, Donna Niedzwiecki, Michiaki Kubo, Yukihide Momozawa, Paula N. Friedman, Fei Shen, Bryan P. Schneider, Bert H. O’Neil, Chen Jiang, Flora Mulkey, Megan Li
Supplemental Methods, Tables and Figures Table S1. Analyzed candidate genes Table S2. Gene sets and pathways used for candidate gene selection Table S3. Quality of sequencing reads per sample Table S4. Post-QC quality per sample Table S5. Replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7f6e43ffa601f9d5a68422bda7d13a
https://doi.org/10.1158/1078-0432.22464992
https://doi.org/10.1158/1078-0432.22464992
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
Sensitivity to mechanical stimuli with Von Frey filaments for C57BL/6J mice and litter-mates heterozygous for VAC14 prior to docetaxel treatment. The figure displays the estimate of the proportion of mice without a hind-paw withdrawal response to sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251451330d12689d87600c9425137ec1
https://doi.org/10.1158/1078-0432.22468631.v1
https://doi.org/10.1158/1078-0432.22468631.v1
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
CONSORT diagram illustrating patient flow from enrollment on parent study to population included in pharmacogenetic discovery analysis and quality control filtering of SNPs from the Illumina HumanHap610-Quad into the pharmacogenetic analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6236f80643eb74c894f2bf27d35d53ff
https://doi.org/10.1158/1078-0432.22468637
https://doi.org/10.1158/1078-0432.22468637
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
Most Highly Enriched Canonical Pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da56ace15d709f0f151f741a2acb26e
https://doi.org/10.1158/1078-0432.22468619
https://doi.org/10.1158/1078-0432.22468619