Výsledky vyhledávání - "Paula Moyano"

Akademický článek

Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment

Autor: Paula Moyano, Andrea Flores, María de la Cabeza Fernández, Jimena García, Javier Sanjuan, José Carlos Plaza, Javier Del Pino

Publikováno v: Foods, Vol 13, Iss 15, p 2427 (2024)

Chlorpyrifos (CPF) biocide, exposure to which is mainly produced in the human population through diet, induces several neurotoxic effects. CPF single and repeated exposure induces memory and learning disorders, although the mechanisms that produce th

Externí odkaz: https://doaj.org/article/fb62872c87244d7893300846c3aeed15

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Akademický článek

Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools

Autor: Paula Moyano, Emma Sola, María Victoria Naval, Lucia Guerra-Menéndez, Maria De la Cabeza Fernández, Javier del Pino

Publikováno v: Pharmaceutics, Vol 15, Iss 8, p 2048 (2023)

Environmental pollutants’ (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be related to EPs, as their incidence has increased in a similar way to hum

Externí odkaz: https://doaj.org/article/9258bda66a33444aba27b492b21b9542

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Akademický článek

Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo

Autor: Andrea Flores, Paula Moyano, Emma Sola, José Manuel García, Jimena García, María Teresa Frejo, Lucia Guerra-Menéndez, Elena Labajo, Inés Lobo, Luisa Abascal, Javier del Pino

Publikováno v: Biology, Vol 12, Iss 6, p 782 (2023)

The widely used plasticizer bisphenol-A (BPA) is well-known for producing neurodegeneration and cognitive disorders, following acute and long-term exposure. Although some of the BPA actions involved in these effects have been unraveled, they are stil

Externí odkaz: https://doaj.org/article/21a73fe3b4d84de0b36410f5b1b63499

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Akademický článek

Relación entre el feedback emocional, feedback cognitivo-verbal y percepción emocional en la variante frontal de demencia frontotemporal resultados preliminares Relationship Between Emotional Feedback, Verbal-Cognitive Feedback And Emotional Perception In The Frontal Variant Of Frontotemporal Dementia Preliminary Results

Autor: Florencia Calodolce, Daniel Politis, Paula Moyano

Publikováno v: Anuario de Investigaciones, Vol 15, p 0 (2008)

Numerosos estudios hallaron disociaciones, tanto entre las pruebas de cognición social entre sí, como entre éstas y las que evalúan funciones ejecutivas, lo cual apoya la idea de que el feedback emocional, la percepción emocional y el feedback c

Externí odkaz: https://doaj.org/article/968e412a3a2e4311aaebb0d331cbaf87

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Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ

Autor: Maria Luisa, Abascal, Javier, Sanjuan, Paula, Moyano, Emma, Sola, Andrea, Flores, José Manuel, Garcia, Jimena, Garcia, María Teresa, Frejo, Javier, Del Pino

Publikováno v: Chemical research in toxicology. 35(12)

Acute and long-term paraquat (PQ) exposure produces hippocampal neurodegeneration and cognition decline. Although some mechanisms involved in these effects were found, the rest are unknown. PQ treatment, for 1 and 14 days, upregulated interferon-gamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b4630ba3464b1b6589f57b2dee44ff6
https://pubmed.ncbi.nlm.nih.gov/36394833

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Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ1–42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells

Autor: Maria Luisa Abascal, Javier Sanjuan, Paula Moyano, Emma Sola, Andrea Flores, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, Javier del Pino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381124dd4961267900a07b3cf80f60bf
https://eprints.ucm.es/id/eprint/75719/

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Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/β-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment

Autor: Pilar Muñoz-Calero, Adela Pelayo, José Manuel García, Paula Moyano, María Teresa Frejo, A. Flores, Javier del Pino, Jimena García

Publikováno v: Chemical Research in Toxicology. 34:2019-2023

The biocide chlorpyrifos (CPF) was described to increase breast cancer risk in humans, to produce breast cancer in animals, and to induce cell proliferation in MCF-7 and MDA-MB-231 cells after 1 and 14 days of treatment. The entire mechanisms related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a01db15d4dacded529f54e2bfb63613
https://doi.org/10.1021/acs.chemrestox.1c00258

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Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation

Autor: Paula Moyano, David Vicente-Zurdo, Cristina Blázquez-Barbadillo, J. Carlos Menéndez, Juan F. González, Noelia Rosales-Conrado, Javier del Pino

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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Brain's metals accumulation is associated with toxic proteins, like amyloid-proteins (Aβ), formation, accumulation, and aggregation, leading to neurodegeneration. Metals downregulate the correct folding, disaggregation, or degradation mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdff1b64dc43f713df796e8b497f266
https://eprints.ucm.es/id/eprint/73454/

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