Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Paula Merino-Serrais"'
Autor:
Paula Merino-Serrais, Sergio Plaza-Alonso, Farida Hellal, Susana Valero-Freitag, Asta Kastanauskaite, Nikolaus Plesnila, Javier Defelipe
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S610- (2023)
Externí odkaz:
https://doaj.org/article/29722bec87f8418eaec981844a62aa52
Autor:
Mite Mijalkov, Giovanni Volpe, Isabel Fernaud-Espinosa, Javier DeFelipe, Joana B. Pereira, Paula Merino-Serrais
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the los
Externí odkaz:
https://doaj.org/article/1d034dbf4fa34ac4b7eba3dd4ccfc10a
Autor:
Raul Loera-Valencia, Erika Vazquez-Juarez, Alberto Muñoz, Gorka Gerenu, Marta Gómez-Galán, Maria Lindskog, Javier DeFelipe, Angel Cedazo-Minguez, Paula Merino-Serrais
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer’s disease (AD). However, global cholesterol-lowering therapies have yielded mixed results when it comes to slowing down or pr
Externí odkaz:
https://doaj.org/article/0b049b45ec844c18afc7850c0fa00835
Autor:
Sean Quinlan, Paula Merino-Serrais, Alessandra Di Grande, Heiko Dussmann, Jochen H. M. Prehn, Tríona Ní Chonghaile, David C. Henshall, Eva M. Jimenez-Mateos
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent studies suggest that mild hypoxia-induced neonatal seizures can trigger an acute neuroinflammatory response leading to long-lasting changes in brain excitability along with associated cognitive and behavioral deficits. The cellular elements an
Externí odkaz:
https://doaj.org/article/55e4f4013e064808ac58e126559dbf5c
Autor:
Shira Knafo, César Venero, Cristina Sánchez-Puelles, Inmaculada Pereda-Peréz, Ana Franco, Carmen Sandi, Luz M Suárez, José M Solís, Lidia Alonso-Nanclares, Eduardo D Martín, Paula Merino-Serrais, Erika Borcel, Shizhong Li, Yongshuo Chen, Juncal Gonzalez-Soriano, Vladimir Berezin, Elisabeth Bock, Javier Defelipe, José A Esteban
Publikováno v:
PLoS Biology, Vol 10, Iss 2, p e1001262 (2012)
Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL
Externí odkaz:
https://doaj.org/article/c8afde1bf0774f8a8e1624331a6f7835
Autor:
Edita Bulovaite, Zhen Qiu, Maximilian Kratschke, Adrianna Zgraj, David G. Fricker, Eleanor J. Tuck, Ragini Gokhale, Babis Koniaris, Shekib A. Jami, Paula Merino-Serrais, Elodie Husi, Lorena Mendive-Tapia, Marc Vendrell, Thomas J. O’Dell, Javier DeFelipe, Noboru H. Komiyama, Anthony Holtmaat, Erik Fransén, Seth G.N. Grant
Publikováno v:
Neuron
Bulovaite, E, Qiu, Z, Kratschke, M, Zgraj, A, Fricker, D G, Tuck, E J, Gokhale, R, Koniaris, B, Jami, S A, Merino-Serrais, P, Husi, E, Mendive-Tapia, L, Vendrell, M, O'Dell, T J, DeFelipe, J, Komiyama, N H, Holtmaat, A, Fransén, E & Grant, S G N 2022, ' A brain atlas of synapse protein lifetime across the mouse lifespan ', Neuron . https://doi.org/10.1016/j.neuron.2022.09.009
Bulovaite, E, Qiu, Z, Kratschke, M, Zgraj, A, Fricker, D G, Tuck, E J, Gokhale, R, Koniaris, B, Jami, S A, Merino-Serrais, P, Husi, E, Mendive-Tapia, L, Vendrell, M, O'Dell, T J, DeFelipe, J, Komiyama, N H, Holtmaat, A, Fransén, E & Grant, S G N 2022, ' A brain atlas of synapse protein lifetime across the mouse lifespan ', Neuron . https://doi.org/10.1016/j.neuron.2022.09.009
The lifetime of proteins in synapses is important for their signaling, maintenance, and remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an abundant postsynaptic protein in excitatory synapses, at single-synapse re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ab62ef318976a1b25f15c5b508a7f7
http://hdl.handle.net/10261/305259
http://hdl.handle.net/10261/305259
Autor:
Paula Merino-Serrais, Sergio Plaza-Alonso, Farida Hellal, Susana Valero-Freitag, Asta Kastanauskaite, Alberto Muñoz, Nikolaus Plesnila, Javier DeFelipe
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
Cereb. Cortex 33, 1074-1089 (2022)
instname
Cereb. Cortex 33, 1074-1089 (2022)
At present, many studies support the notion that after stroke, remote regions connected to the infarcted area are also affected and may contribute to functional outcome. In the present study, we have analyzed possible microanatomical alterations in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3961eee9bbccfc16404d43f3e6148605
https://eprints.ucm.es/id/eprint/74981/1/Munoz-Cespedes-DBC-Microanatomical-study.pdf
https://eprints.ucm.es/id/eprint/74981/1/Munoz-Cespedes-DBC-Microanatomical-study.pdf
Autor:
Paula Merino-Serrais, Giovanni Volpe, Isabel Fernaud-Espinosa, Joana B. Pereira, Mite Mijalkov, Javier DeFelipe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the loss of dend
Autor:
Cristina Parrado-Fernandez, Paula Merino-Serrais, Silvia Maioli, Raúl Loera-Valencia, Julen Goikolea
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the complete pathogenesis of the disease is still unknown. High leve
Autor:
Ingemar Björkhem, Henrik Zetterberg, Francesca Eroli, Latorre-Leal M, Kaj Blennow, Paula Merino-Serrais, Miia Kivipelto, William J. Griffiths, Pacciarini M, Silvia Maioli, Bengt Winblad, Sandebring Matton A, Yuqin Wang, Angel Cedazo-Minguez, Franchini L, Daniilidou M, Patricia Rodriguez-Rodriguez
Cholesterol turnover and CYP46A1 regulation are reported to be crucial for memory functions. An increasing body of evidence shows that CYP46A1 activation is able to reduce Alzheimer’s Disease (AD) pathological processes. In this study we report for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e872f78466311606239c95c44eef6033
https://doi.org/10.1101/2021.04.23.441050
https://doi.org/10.1101/2021.04.23.441050