Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Paula Martikainen"'
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 14:353-359
The authors constructed tissue microarray (TMA) blocks from human postmortem brain including numerous core samples measuring 2 mm in diameter from various anatomic regions. These TMA sections were then processed using various stainings and pretreatme
Publikováno v:
Brain Research. 1089:33-43
We constructed tissue microarray (TMA) blocks containing post-mortem human brain tissue from subjects with clinically and neuropathologically verified Alzheimer's disease (AD), corticobasal degeneration (CBD), progressive supranuclear palsy, Lewy bod
Autor:
Paula Martikainen, Thomas G. Pretlow, Matthew J. LeBaron, Hongzhen Li, Martti Nurmi, Kalle Alanen, Ying Zhang, Marja T. Nevalainen, Jianwu Xie, Tommi J. Ahonen, Baljit Singh, Erica L. Ealley
Publikováno v:
Cancer Research. 64:4774-4782
We have recently identified signal transducer and activator of transcription 5 (Stat5) as a critical survival factor for prostate cancer cells. We now report that activation of Stat5 is associated with high histological grade of human prostate cancer
Autor:
Susanna Hinkka, Leena Anttila, Pirkko Härkönen, P. J. Klemi, Paula Martikainen, Jani Seppänen, S. Oksjoki, Eeva M. Valve, Seija Grénman
Publikováno v:
International Journal of Cancer. 88:718-725
FGF-8 is a mitogenic growth factor, which is widely expressed during embryonic development but only at a very low level in adult tissues. Alternative splicing of the human FGF-8 gene potentially allows coding for 4 protein isoforms (a, b, e, f), whic
Autor:
Paula Martikainen, Pirkko Härkönen, Tommi J. Ahonen, Hallgeir Rui, Marja T. Nevalainen, Jukka Laine
Publikováno v:
Endocrinology. 140:5412-5421
PRL is one of several polypeptide factors that regulate growth and differentiation of prostate epithelium besides steroid hormones. This hormone may also participate in the development of pathologic changes of the prostate, as evidenced by marked pro
Autor:
Reidar Grénman, Paula Martikainen, Heikki Joensuu, K. Servomaa, Liisa Elomaa, Jaakko Pulkkinen
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 122:214-218
Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we
Publikováno v:
JNCI Journal of the National Cancer Institute. 85:1412-1418
BACKGROUND Antiestrogens inhibit the stimulative effects of estrogens on breast cancer growth, but the mechanism(s) by which they trigger tumor regression are not completely understood. Growth retardation and tumor regression can be achieved by enhan
Publikováno v:
Journal of neuropathology and experimental neurology. 69(1)
The goals of this study were to determine the effects of prolonged fixation time and to optimize antigen retrieval (AR) methods on immunohistochemical (IHC) staining of common neurodegenerative disease markers. A panel of commercial antibodies (Abs)
Autor:
Paula Martikainen, John T. Isaacs
Publikováno v:
Endocrinology. 127:1268-1277
Glandular epithelial cells of the rat ventral prostate undergo programmed cell death in vivo following androgen ablation. Fragmentation of the prostatic DNA is an irreversible commitment step in this programmed cell death process. The amount of prost
Publikováno v:
Journal of Steroid Biochemistry. 35:249-256
The 5α-reduction of testosterone to dihydrotestosterone (DHT) correlates with the androgen-mediated growth of the prostate under different experimental and clinical conditions. The aim was to study the regulation of the prostatic growth and enzyme a