Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paula Martínez-Cristóbal"'
Autor:
Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degrad
Externí odkaz:
https://doaj.org/article/6c6c515e273b446cb66da2f55b7b3d95
Autor:
Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/d1198cecc1114d42ba57e2c691ec211c
Autor:
Alba Sabaté-Pérez, Montserrat Romero, Paula Sànchez-Fernàndez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Paula Martínez-Cristóbal, Josep A Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacín, Xavier Testar, Antonio Zorzano
Publikováno v:
Autophagy. 19:904-925
Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the potential to induce weight loss and to prevent obesity. Here, we document a macroautophagic/autophagic-dependent mechanism of peroxisome proliferator-activated re
Autor:
Shaon Basu, Paula Martínez-Cristóbal, Mireia Pesarrodona, Marta Frigolé-Vivas, Michael Lewis, Elzbieta Szulc, C. Adriana Bañuelos, Carolina Sánchez-Zarzalejo, Stasė Bielskutė, Jiaqi Zhu, Karina Pombo-García, Carla Garcia-Cabau, Cristina Batlle, Borja Mateos, Mateusz Biesaga, Albert Escobedo, Lídia Bardia, Xavier Verdaguer, Alessandro Ruffoni, Nasrin R. Mawji, Jun Wang, Teresa Tam, Isabelle Brun-Heath, Salvador Ventura, David Meierhofer, Jesús García, Paul Robustelli, Travis H. Stracker, Marianne D. Sadar, Antoni Riera, Denes Hnisz, Xavier Salvatella
SummaryTranscription factors are among the most attractive therapeutic targets but are considered largely undruggable due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the activation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647a49166ea017e1660f5ae923fe0668
https://doi.org/10.1101/2022.08.18.504385
https://doi.org/10.1101/2022.08.18.504385
Autor:
Isabella C. Felli, Jesús García, Roberta Pierattelli, Samir R. Nath, Paula Martínez-Cristóbal, Giulio Chiesa, Andrew P. Lieberman, Zhigang Yu, Xavier Salvatella, Daniel M. C. Schwarz, Claudio Di Sanza, Bahareh Eftekharzadeh, Jennifer N. Rauch, Elisa Giorgetti, Varuna C. Banduseela, Marta Marin-Argany, Isabelle Brun-Heath, Angel R. Nebreda, Jason E. Gestwicki, Hao Shao
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3006d7de3e115a9649d8bf1c63fb04
https://escholarship.org/uc/item/1s17d7p6
https://escholarship.org/uc/item/1s17d7p6
Autor:
Paula Martínez-Cristóbal, Gianni De Fabritiis, Marta Frigolé-Vivas, Xavier Salvatella, Eva Estébanez-Perpiñá, Irene Hunter, Elzbieta Szulc, Ángel R. Nebreda, Eva De Mol, Claudio Di Sanza, Marianela Masin, R. Bryn Fenwick, Victor Buzon, Jesús García, Carlos W. Bertoncini, Isabelle Brun-Heath, Iain J. McEwan
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these in
Autor:
Saška Ivanova, María Isabel Hernández-Alvarez, Juan Pablo Muñoz, Jana Sánchez-Wandelmer, David Sebastián, Ana Sancho, Paula Martínez-Cristóbal, Antonio Zorzano, Angels Díaz-Ramos, Eduard Noguera, Caroline Mauvezin, Manuel Palacín
Publikováno v:
The EMBO Journal; Vol 32
Mitofusin 2 (Mfn2) is a key protein in mitochondrial fusion and it participates in the bridging of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation leads to ER stress. Here we report on the mechanisms by which M
Autor:
Jennifer N. Rauch, Andrew P. Lieberman, Varuna C. Banduseela, Roberta Pierattelli, Hao Shao, Giulio Chiesa, Marta Marin-Argany, Zhigang Yu, Claudio Di Sanza, Xavier Salvatella, Bahareh Eftekharzadeh, Jason E. Gestwicki, Daniel M. C. Schwarz, Angel R. Nebreda, Elisa Giorgetti, Isabelle Brun-Heath, Paula Martínez-Cristóbal, Samir R. Nath, Jesús García, Isabella C. Felli
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that