Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Paula M. Oliver"'
Autor:
Asif A. Dar, Dale D. Kim, Scott M. Gordon, Kathleen Klinzing, Siera Rosen, Ipsita Guha, Nadia Porter, Yohaniz Ortega, Katherine S. Forsyth, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Laurence C. Eisenlohr, Edward M. Behrens, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk f
Externí odkaz:
https://doaj.org/article/13ee6ca256cb4b35a160900e56452abc
Autor:
Binod Kumar, Natania S. Field, Dale D. Kim, Asif A. Dar, Yanqun Chen, Aishwarya Suresh, Christopher F. Pastore, Li-Yin Hung, Nadia Porter, Keisuke Sawada, Palak Shah, Omar Elbulok, Emily K. Moser, De’Broski R. Herbert, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cytokine signaling influences the differentiation of CD4+ T cells into varying functional subsets. Here the authors show that an E3 ubiquitin ligase Cul5 alters TH2 and TH9 development and absence of Cul5 in T cells results in higher levels of allerg
Externí odkaz:
https://doaj.org/article/d9e5115c68644de29848a0530e463a6f
Autor:
Awo Akosua Kesewa Layman, Guoping Deng, Claire E. O’Leary, Samuel Tadros, Rajan M. Thomas, Joseph M. Dybas, Emily K. Moser, Andrew D. Wells, Nicolai M. Doliba, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metab
Externí odkaz:
https://doaj.org/article/89da5cb9551e485e8433cc421115f741
Autor:
Madhavi Gorla, Celine Santiago, Karina Chaudhari, Awo Akosua Kesewa Layman, Paula M. Oliver, Greg J. Bashaw
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3298-3312.e4 (2019)
Summary: Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In insects and mammals, negative regulation of R
Externí odkaz:
https://doaj.org/article/307034212df34e88a8ebfa9fd91a9a07
Autor:
Claire E. O’Leary, Christopher R. Riling, Lynn A. Spruce, Hua Ding, Suresh Kumar, Guoping Deng, Yuhong Liu, Steven H. Seeholzer, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Ndfip1 is an activator of Itch E3 ubiquitin ligase that limits T cell activation. Here the authors identify Jak1 in a proteomic screen for Ndfip dependent substrates, and show that Ndfip1/2 double-deficient T cells have reduced degradation of Jak1 an
Externí odkaz:
https://doaj.org/article/db42816efdd94bf7b6b714a9b6e7cec3
Autor:
Asif A Dar, Keisuke Sawada, Joseph M Dybas, Emily K Moser, Emma L Lewis, Eddie Park, Hossein Fazelinia, Lynn A Spruce, Hua Ding, Steven H Seeholzer, Paula M Oliver
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001041 (2021)
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. Here we pr
Externí odkaz:
https://doaj.org/article/1ccf70c70537433581dda2a256654825
Autor:
Emily K Moser, Joseph M Dybas, Steven H. Seeholzer, Lynn A. Spruce, Paula M. Oliver, Michael P. Cancro, Jennifer Roof
Publikováno v:
The Journal of Experimental Medicine
Itch is a catalytic ubiquitin ligase that prevents autoimmunity in humans and mice. Here, Moser et al. show that Itch negatively regulates B cell proliferation and metabolic fitness to limit antigen-driven B cell responses and antibody production aft
Autor:
Paula M. Oliver, Hua Ding, Joseph M Dybas, Steven H. Seeholzer, Claire E. O’Leary, Lynn A. Spruce
Publikováno v:
Nat Immunol
Despite gathering evidence that ubiquitylation can direct non-degradative outcomes, most investigations of ubiquitylation in T cells have focused on degradation. Here, we integrated proteomic and transcriptomic datasets from primary mouse CD4(+) T ce
Autor:
Asif Amin Dar, Scott Gordon, Kathleen Klinzing, Kim Dale, Nadia Porter, Ipsita Guha, Edward M Behrens, Paula M Oliver
Publikováno v:
The Journal of Immunology. 208:57.06-57.06
CD8+ T cells play crucial roles in cellular immune mechanisms that clear invading viruses and prevent reinfection. Virus specific CD8+ T cells expand approximately 10,000 fold, undergoing up to 20 cell divisions in the first week of infection. While
Publikováno v:
The Journal of Immunology. 208:109.16-109.16
Over the past few years we have witnessed a change in the study of allergic inflammation from a view that holds T helper type 2 cells at the centre of immune orchestration to one that appreciates the significant contribution made by innate lymphoid t