Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Paula M. Miotto"'
Autor:
Hamzeh Karimkhanloo, Stacey N. Keenan, Jacqueline Bayliss, William De Nardo, Paula M. Miotto, Camille J. Devereux, Shuai Nie, Nicholas A. Williamson, Andrew Ryan, Matthew J. Watt, Magdalene K. Montgomery
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong contributors to liver-related and overall mortality. Despite the high g
Externí odkaz:
https://doaj.org/article/0f81f952cf38469ca8daa7ce5886971f
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N. Keenan, Paula M. Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B. Schittenhelm, Anthony S. Don, Andrew Ryan, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Benjamin L. Parker, Matthew J. Watt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, but the connecting pathophysiological mechanisms are incompletely understood. Here the authors identify arylsulfatase A as a NASH-induced hepatokine that inhibits hepatic ly
Externí odkaz:
https://doaj.org/article/0e3d36630f204b8aa3e526d0e0913eb1
Autor:
William De Nardo, Paula M. Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101491- (2022)
Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion of liver proteins known as hepatokines. Regular physical activity can resolve N
Externí odkaz:
https://doaj.org/article/703f3df833344ba2a9037ed17054464f
Autor:
Justin P. Hardee, Karen J.B. Martins, Paula M. Miotto, James G. Ryall, Stefan M. Gehrig, Boris Reljic, Timur Naim, Jin D. Chung, Jen Trieu, Kristy Swiderski, Ashleigh M. Philp, Andrew Philp, Matthew J. Watt, David A. Stroud, Rene Koopman, Gregory R. Steinberg, Gordon S. Lynch
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101157- (2021)
Objectives: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an oxidative phenotype could protect muscles from damage and ameliorate the dystrophic pat
Externí odkaz:
https://doaj.org/article/b08e8562dbf04514b4f8033e63900eca
Autor:
Graham P. Holloway, Andrew M. Holwerda, Paula M. Miotto, Marlou L. Dirks, Lex B. Verdijk, Luc J.C. van Loon
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2837-2848 (2018)
Summary: It remains unknown if mitochondrial bioenergetics are altered with aging in humans. We established an in vitro method to simultaneously determine mitochondrial respiration and H2O2 emission in skeletal muscle tissue across a range of biologi
Externí odkaz:
https://doaj.org/article/1de831531b134e6d8dfad55dd180540d
Autor:
Paula M. Miotto, Laura M. Castelli, Foyinsola Amoye, Paul J. LeBlanc, Sandra J. Peters, Brian D. Roy, Wendy E. Ward
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 15094-15109 (2013)
High fat diets adversely affect body composition, bone mineral and strength, and alter bone fatty acid composition. It is unclear if maternal high fat (HF) feeding permanently alters offspring body composition and bone health. Female rats were fed co
Externí odkaz:
https://doaj.org/article/73d9a958ffde40fe8d9b1ced5728aa7f
Publikováno v:
The Journal of Physiology. 599:4745-4747
Autor:
Heather L. Petrick, Luc J. C. van Loon, Gijs H. Goossens, Marlou L. Dirks, Janneau van Kranenburg, Joan M. G. Senden, Paula M. Miotto, Graham P. Holloway
Publikováno v:
Journal of Physiology, 598(1), 123-137. Wiley
Key points: We determined if bed rest increased mitochondrially derived reactive oxygen species and cellular redox stress, contributing to the induction of insulin resistance. Bed rest decreased maximal and submaximal ADP-stimulated mitochondrial res
Autor:
Ronnie Blazev, Christian S. Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T. Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J. Kueh, Paula M. Miotto, Vanessa R. Haynes, Justin P. Hardee, Jin D. Chung, James W. McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S. Oakhill, Marco J. Herold, Thomas E. Jensen, Leszek Lisowski, Gordon S. Lynch, Garron T. Dodd, Matthew J. Watt, Pengyi Yang, Bente Kiens, Erik A. Richter, Benjamin L. Parker
Publikováno v:
Cell Metabolism. 34:1561-1577.e9
Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signaling networks during and after different exercise modalities, we performed a phosphoproteomic analysis of human skeletal
Autor:
Paula M. Miotto, Graham P. Holloway
Publikováno v:
Mitochondrion. 46:116-122
Acute exercise rapidly induces mitochondrial gene expression, however, the intracellular events regulating this process remain incompletely understood. The purpose of this study was to determine whether reductions in mitochondrial ADP sensitivity dur