Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Paula M. Jacobi"'
Autor:
Qianyi Ma, Paula M. Jacobi, Brian T. Emmer, Colin A. Kretz, Ayse Bilge Ozel, Beth McGee, Chava Kimchi-Sarfaty, David Ginsburg, Jun Z. Li, Karl C. Desch
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1037-1046 (2017)
Abstract: The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) in circulating blood, limiting the size of VWF multimers and regulating VWF activity. Abnormal regulation of VWF contributes to bleeding and to thrombotic disorders. ADAMTS13
Externí odkaz:
https://doaj.org/article/34d445472d274fd4b9422c0423282360
Publikováno v:
Blood. 140:5522-5524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd08a9ddd40f098234fd9ac64a61dce2
https://doi.org/10.1182/blood-2022-163213
https://doi.org/10.1182/blood-2022-163213
Autor:
David Jakab, A. L. Gehrand, Sachiko Kanaji, Paula M. Jacobi, J. M. Johnsen, Sandra L. Haberichter
Publikováno v:
Journal of Thrombosis and Haemostasis. 16:546-554
Essentials Reduced survival of von Willebrand factor (VWF) in plasma causes type 1C von Willebrand disease. Blood was collected from mouse strains by various methods and VWF propeptide and antigen assayed. VWF propeptide to antigen ratio identifies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fee41e9553b04b9211b68919c7b5962
https://doi.org/10.1111/jth.13934
https://doi.org/10.1111/jth.13934
Autor:
Beth McGee, Jun Li, Qianyi Ma, Colin A. Kretz, Karl C. Desch, Paula M. Jacobi, David Ginsburg, Brian T. Emmer, Ayse Bilge Ozel, Chava Kimchi-Sarfaty
Publikováno v:
Blood Advances. 1:1037-1046
The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) in circulating blood, limiting the size of VWF multimers and regulating VWF activity. Abnormal regulation of VWF contributes to bleeding and to thrombotic disorders. ADAMTS13 levels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5deda932b9726e8a9fd1bf0a843c7737
https://doi.org/10.1182/bloodadvances.2017005629
https://doi.org/10.1182/bloodadvances.2017005629
Autor:
Sarah E. Sartain, Paula M Jacobi
Publikováno v:
Blood. 136:29-30
Introduction Thrombotic microangiopathy (TMA) is a group of disorders presenting with microvascular thrombosis, microangiopathic hemolytic anemia, thrombocytopenia, and microvascular endothelial injury ultimately leading to end organ damage. Atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8612f6c922bd7191619096d4070fa3a7
https://doi.org/10.1182/blood-2020-141240
https://doi.org/10.1182/blood-2020-141240
Autor:
Pieter H. Reitsma, Mary Underwood, David Ginsburg, Krista Golden, Matt Halvorsen, Paula M. Jacobi, Frances M K Williams, David-Alexandre Trégouët, Ayse Bilge Ozel, Karl C. Desch, J. Brent Richards, Lauren E. Mokry, Jun Li, Clive Kearon, Marine Germain, David Goldstein
Publikováno v:
Blood
Deep vein thrombosis and pulmonary embolism, collectively defined as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in the United States. Common genetic variants conferring increased varying degrees of VTE risk have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8429e48f57f02bde2744ace0ea6a7d5f
https://pubmed.ncbi.nlm.nih.gov/34461736
https://pubmed.ncbi.nlm.nih.gov/34461736
Autor:
Gianluca Interlandi, Sandra L. Haberichter, Dominic W. Chung, José A. López, Randall Wong, Jesse Hinckley, Veronica H. Flood, Junmei Chen, Paula M. Jacobi, Jorge Di Paola, Robert R. Montgomery
Publikováno v:
Blood. 126:262-269
Von Willebrand disease (VWD) is an inherited bleeding disorder characterized by incomplete penetrance and variable expressivity. We evaluated a 24-member pedigree with VWD type 2 caused by a T>G mutation at position 3911 that predicts a methionine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd37adb593007d73dafaed852951ac3
https://doi.org/10.1182/blood-2014-11-613935
https://doi.org/10.1182/blood-2014-11-613935
Autor:
Amy L. Dunn, Adam Cuker, David Green, Cindy A. Leissinger, J. Gill, Abraham C. Schlauderaff, Bryce A. Kerlin, D. M. Di Michele, Joan Cox Gill, F. Shafer, A. Shapiro, Steven R. Lentz, Deborah L Brown, Madhvi Rajpurkar, Janna M. Journeycake, Robert R. Montgomery, Veronica H. Flood, Sandra L. Haberichter, Michael J. Paidas, Carolyn M. Bennett, Michael D. Tarantino, Roshni Kulkarni, Carol Diamond, Kenneth D. Friedman, Liesl Mathias, A. Matsunaga, Anne T. Neff, Paula M. Jacobi, Thomas C. Abshire, A. Bedros, Daniel B. Bellissimo, Margaret V. Ragni, M L Manco-Johnson, Tricia L. Slobodianuk, Pamela A. Christopherson, Barbara A. Konkle, Anjali Sharathkumar, Peter A. Kouides, A. Cohen, Eric J. Werner, John J. Strouse, Ralph A. Gruppo, Dagmar T. Stein, Jeffrey D. Hord, Raymond G. Hoffmann, Lisa N. Boggio, Leonard A. Valentino, Jeanne M. Lusher, Alice D. Ma, Donald H. Mahoney, Patricia J. Giardina
Publikováno v:
Blood. 125:2297-2304
Von Willebrand factor (VWF) contains binding sites for platelets and for vascular collagens to facilitate clot formation at sites of injury. Although previous work has shown that VWF can bind type IV collagen (collagen 4), little characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a2cd799055edadce5d61fb10e1d4eb
https://doi.org/10.1182/blood-2014-11-610824
https://doi.org/10.1182/blood-2014-11-610824
Autor:
Raymond G. Hoffmann, Pamela A. Christopherson, Joan Cox Gill, Robert R. Montgomery, Kenneth D. Friedman, Veronica H. Flood, Paula M. Jacobi, Sandra L. Haberichter
Publikováno v:
Clinical Chemistry. 59:684-691
BACKGROUND von Willebrand factor (VWF) is a multimeric protein that binds platelets and collagen, facilitating hemostasis at sites of vessel injury. Measurement of VWF multimer distribution is critical for diagnosis of variant von Willebrand disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcde8c2f88f6c1530edd3226dca0fbe
https://doi.org/10.1373/clinchem.2012.199000
https://doi.org/10.1373/clinchem.2012.199000
Autor:
Christopher J. Ng, Tara C. White-Adams, Jorge Di Paola, Paula M. Jacobi, Sandra L. Haberichter
Publikováno v:
Thrombosis research. 145
Type 1 von Willebrand disease (VWD) is characterized by low plasma levels of von Willebrand factor (VWF) and clinical bleeding. Several mechanisms have been described that cause a decrease in plasma VWF levels in VWD, and the goal of this study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45ef498f8a3151efcd523ab7ed95bbc
https://pubmed.ncbi.nlm.nih.gov/27533707
https://pubmed.ncbi.nlm.nih.gov/27533707