Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paula M. B. Pahl"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 45:539-544
Endothelial cell (EC) and vascular smooth muscle cell (VSMC) interactions play critical roles in restenosis following vascular injury. We examined the effects of intracellular iron chelation on endothelial cell cycle progression and VSMC modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043f4ff98bb5fceb9a90c7b4f2c0237c
https://doi.org/10.1097/01.fjc.0000159659.78675.4a
https://doi.org/10.1097/01.fjc.0000159659.78675.4a
Autor:
Lawrence D. Horwitz, Paula M. B. Pahl
Publikováno v:
Cancer Investigation. 23:683-691
Iron is an essential micronutrient for the growth and function of all cells. It is, therefore, an attractive target for chemotherapeutic compounds. Numerous studies in vitro and in vivo provide evidence that iron chelators may be effective antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a087eb07f1f8159bb3008a6ea2c7f44
https://doi.org/10.1080/07357900500359976
https://doi.org/10.1080/07357900500359976
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:226-232
Peroxiredoxin (Prx) is an important antioxidant defense enzyme that reduces hydrogen peroxide to molecular oxygen by using reducing equivalents from thioredoxin. We report that lung Prx I messenger RNA (mRNA) is specifically upregulated by oxygen. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35bd79c34194882380f83af4a0e56c0
https://doi.org/10.1165/ajrcmb.25.2.4314
https://doi.org/10.1165/ajrcmb.25.2.4314
Autor:
Yvonne K. Hodges, Paula M. B. Pahl, Eli A. Rosenthal, Xiang-Dong Yan, Lawrence D. Horwitz, Marcus A. Horwitz
Publikováno v:
Journal of Biological Chemistry. 275:17821-17826
Proliferation of vascular smooth muscle cells (VSMC) is characteristic of restenosis following balloon angioplasty. We show here that a low concentration of a novel iron chelator, desferri-exochelin 772SM, reversibly arrests the growth of human VSMC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689fb9c539f6528c36cb4c663bcadcc9
https://doi.org/10.1074/jbc.m909918199
https://doi.org/10.1074/jbc.m909918199
Publikováno v:
Journal of experimental therapeuticsoncology. 6(3)
The lipid-soluble iron chelator desferri-exochelin (D-Exo) causes reversible cell cycle arrest in normal human mammary epithelial cells (NHMEC) but triggers apoptotic cell death in human breast cancer cells. We studied the effects of iron chelation w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f47b422dfe487d5468aad79b51f4af84
https://pubmed.ncbi.nlm.nih.gov/17552359
https://pubmed.ncbi.nlm.nih.gov/17552359
Autor:
Kathryn B. Horwitz, Paula M. B. Pahl, M. B. Perryman, Yvonne K. Hodges, L. Meltesen, Lawrence D. Horwitz
Publikováno v:
Genomics. 53:410-412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ec162338025f86e063920b4b839364
https://doi.org/10.1006/geno.1998.5442
https://doi.org/10.1006/geno.1998.5442
Publikováno v:
Breast cancer research and treatment. 69(1)
A major goal of cancer chemotherapy is the identification of cytotoxic compounds that are highly selective for cancer cells. We describe here one such compound – a novel iron chelator, desferri-exochelin 772SM. This desferri-exochelin has unique ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b56c1f14dabef199a6c91a761a9881
https://pubmed.ncbi.nlm.nih.gov/11759830
https://pubmed.ncbi.nlm.nih.gov/11759830