Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Paula M Oliver"'
Autor:
Asif A Dar, Keisuke Sawada, Joseph M Dybas, Emily K Moser, Emma L Lewis, Eddie Park, Hossein Fazelinia, Lynn A Spruce, Hua Ding, Steven H Seeholzer, Paula M Oliver
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001041 (2021)
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. Here we pr
Externí odkaz:
https://doaj.org/article/1ccf70c70537433581dda2a256654825
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
AbstractT cell receptor (TCR) signaling must be precisely tuned to limit collateral damage and prevent reactivity to self, while still allowing robust protective immune responses that control pathogen invasion. One process that can be used to promote
Externí odkaz:
https://doaj.org/article/cc43a320be7f487eaf4c595ea0a80421
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34478 (2012)
The bacteria inhabiting the mammalian gastrointestinal (GI) tract play a vital role in normal digestion and immune function. In a healthy host, the immune system is tolerant to gut bacteria and does not mount an effector response to bacteria-derived
Externí odkaz:
https://doaj.org/article/b3df68e8714148faa9bcd436e8735678
Autor:
Meredith H Shaffer, Yanping Huang, Evann Corbo, Gregory F Wu, Marielena Velez, John K Choi, Ichiko Saotome, Judy L Cannon, Andrea I McClatchey, Anne I Sperling, Jonathan S Maltzman, Paula M Oliver, Avinash Bhandoola, Terri M Laufer, Janis K Burkhardt
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12404 (2010)
Ezrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling and pol
Externí odkaz:
https://doaj.org/article/56ce580815234058a88d288fe69bec5a
Autor:
Asif A. Dar, Dale D. Kim, Scott M. Gordon, Kathleen Klinzing, Siera Rosen, Ipsita Guha, Nadia Porter, Yohaniz Ortega, Katherine S. Forsyth, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Laurence C. Eisenlohr, Edward M. Behrens, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk f
Externí odkaz:
https://doaj.org/article/13ee6ca256cb4b35a160900e56452abc
Autor:
Binod Kumar, Natania S. Field, Dale D. Kim, Asif A. Dar, Yanqun Chen, Aishwarya Suresh, Christopher F. Pastore, Li-Yin Hung, Nadia Porter, Keisuke Sawada, Palak Shah, Omar Elbulok, Emily K. Moser, De’Broski R. Herbert, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cytokine signaling influences the differentiation of CD4+ T cells into varying functional subsets. Here the authors show that an E3 ubiquitin ligase Cul5 alters TH2 and TH9 development and absence of Cul5 in T cells results in higher levels of allerg
Externí odkaz:
https://doaj.org/article/d9e5115c68644de29848a0530e463a6f
Autor:
Emily K Moser, Joseph M Dybas, Steven H. Seeholzer, Lynn A. Spruce, Paula M. Oliver, Michael P. Cancro, Jennifer Roof
Publikováno v:
The Journal of Experimental Medicine
Itch is a catalytic ubiquitin ligase that prevents autoimmunity in humans and mice. Here, Moser et al. show that Itch negatively regulates B cell proliferation and metabolic fitness to limit antigen-driven B cell responses and antibody production aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9492ec231bfe3c7c1276429dd8e77a8
http://europepmc.org/articles/PMC6719427
http://europepmc.org/articles/PMC6719427
Autor:
Paula M. Oliver, Hua Ding, Joseph M Dybas, Steven H. Seeholzer, Claire E. O’Leary, Lynn A. Spruce
Publikováno v:
Nat Immunol
Despite gathering evidence that ubiquitylation can direct non-degradative outcomes, most investigations of ubiquitylation in T cells have focused on degradation. Here, we integrated proteomic and transcriptomic datasets from primary mouse CD4(+) T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968d9576994f24c9aa8fc0a73f43f33c
https://doi.org/10.1038/s41590-019-0381-6
https://doi.org/10.1038/s41590-019-0381-6
Autor:
Binod, Kumar, Natania S, Field, Dale D, Kim, Asif A, Dar, Yanqun, Chen, Aishwarya, Suresh, Christopher F, Pastore, Li-Yin, Hung, Nadia, Porter, Keisuke, Sawada, Palak, Shah, Omar, Elbulok, Emily K, Moser, De'Broski R, Herbert, Paula M, Oliver
Publikováno v:
Nature communications. 13(1)
Antigen encounter directs CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72266d146caad703b93b84eeac2d7004
https://pubmed.ncbi.nlm.nih.gov/35589717
https://pubmed.ncbi.nlm.nih.gov/35589717
Autor:
Paula M. Oliver, Asif Amin Dar, Emily K Moser, Eddie Park, Lynn A. Spruce, Steven H. Seeholzer, Emma L. Lewis, Joseph M Dybas, Keisuke Sawada, Hossein Fazelinia, Hua Ding
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001041 (2021)
PLoS Biology
PLoS Biology
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. Here we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13928ffd424e36a9b3728364b68f3b94
https://doaj.org/article/1ccf70c70537433581dda2a256654825
https://doaj.org/article/1ccf70c70537433581dda2a256654825