Výsledky vyhledávání - "Paula M O' Connor"

Akademický článek

Saturation mutagenesis of lysine 12 leads to the identification of derivatives of nisin A with enhanced antimicrobial activity.

Autor: Evelyn M Molloy, Des Field, Paula M O' Connor, Paul D Cotter, Colin Hill, R Paul Ross

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58530 (2013)

It is becoming increasingly apparent that innovations from the "golden age" of antibiotics are becoming ineffective, resulting in a pressing need for novel therapeutics. The bacteriocin family of antimicrobial peptides has attracted much attention in

Externí odkaz: https://doaj.org/article/8a176b389f4349b0adac4de721f442ed

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Akademický článek

The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation

Autor: Paula M. O’ Connor, Eileen F. O’ Shea, Paul D. Cotter, Colin Hill, R. Paul Ross

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)

Abstract Bactofencin A is a novel class IId bacteriocin, produced by the intestinal isolate Lactobacillus salivarius DPC6502, which has potent activity against medically significant pathogens including Staphylococcus aureus. This bacteriocin is unusu

Externí odkaz: https://doaj.org/article/c88d2e5ef0df477290231ea0360b64e8

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Nisin M: a bioengineered Nisin A variant that retains full induction capacity but has significantly reduced antimicrobial activity

Autor: Lorraine A. Draper, Colin Hill, R. Paul Ross, Aoife Grainger, Paula M. O’ Connor, Des Field, Michelle O’ Connor

Publikováno v: Appl Environ Microbiol

Nisin A is a potent antimicrobial with potential as an alternative to traditional antibiotics, and a number of genetically modified variants have been created that target clinically relevant pathogens. In addition to antimicrobial activity, nisin aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24544291bd985cbbff4b18c8227db60f
https://hdl.handle.net/10468/12183

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Expression, purification and antimicrobial activity of recombinant pediocin PA-1 M31L, a PA-1 derivative with enhanced stability

Autor: Beatriz Mesa-Pereira, Taís M. Kuniyoshi, Sara Arbulu, Collin Hill, Paul Ross, Ricardo Pinheiro de Souza Oliveira, Paula M. O’ Connor, Paul D. Cotter

Publikováno v: Access Microbiology. 1

Pediocin PA −1 is class IIa bacteriocin that displays efficient antimicrobial activity against pathogenic Listeriaspp. This bacteriocin is known to lose activity during long periods of storage especially at non optimal pH, thus reducing its usefuln

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1016f84ffb4032e3f970f85ba741b8f
https://doi.org/10.1099/acmi.ac2019.po0471

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Bioengineering Nisin to overcome the Nisin Resistance Protein

Autor: Colin Hill, Des Field, R. Paul Ross, Paul D. Cotter, Tony Blake, Paula M. O’ Connor, Harsh Mathur

Publikováno v: Molecular Microbiology.

The emergence and dissemination of antibiotic resistant bacteria is a major medical challenge. Lantibiotics are highly modified bacterially produced antimicrobial peptides that have attracted considerable interest as alternatives or adjuncts to exist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe9a26e00a7293d36e9e8d235f664c8
https://doi.org/10.1111/mmi.14183

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The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation

Autor: R. Paul Ross, Paul D. Cotter, Colin Hill, Eileen F. O’ Shea, Paula M. O’ Connor

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)

Bactofencin A is a novel class IId bacteriocin, produced by the intestinal isolate Lactobacillus salivarius DPC6502, which has potent activity against medically significant pathogens including Staphylococcus aureus. This bacteriocin is unusual in tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc865af8166610f4c7073617a3e73f6
http://europepmc.org/articles/PMC6081437

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Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity

Autor: Colin Hill, Paul D. Cotter, Catalin Iancu, Paula M. O’ Connor, Lorraine A. Draper, R. Paul Ross, Evelyn M. Molloy, Des Field

Publikováno v: Microbial Biotechnology. 6:564-575

The lantibiotic lacticin 3147 consists of two ribosomally synthesized and post-translationally modified antimicrobial peptides, Ltnα and Ltnβ, which act synergistically against a wide range of Gram-positive microorganisms. We performed saturation m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f64c705e08a57cb760d106118c6306b0
https://doi.org/10.1111/1751-7915.12041

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Subspecies diversity in bacteriocin production by intestinalLactobacillus salivariusstrains

Autor: Colin Hill, Eileen F. O’ Shea, Emma J. Raftis, Paul D. Cotter, Paula M. O’ Connor, Catherine Stanton, R. Paul Ross, Paul W. O' Toole

Publikováno v: CIÊNCIAVITAE
ResearcherID

peer-reviewed Addendum to: O’Shea EF, O’Connor PM, Raftis EJ, O’Toole PW, Stanton C, Cotter PD, Ross RP, et al. Production of multiple bacteriocins from a single locus by gastrointestinal strains of Lactobacillus salivarius. J Bacteriol 2011; 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffe1ce11427ad04cf10aff47f308631
https://doi.org/10.4161/gmic.21417

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Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and the gut microbiota in C57BL/6J mice

Autor: Paula M. O’ Connor, John F. Cryan, R. Paul Ross, Liam McAllan, Kanishka N. Nilaweera, Gerald F. Fitzgerald, Helen M. Roche, Paul D. Cotter, Peter Skuse

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88904 (2014)
PLoS ONE

peer-reviewed Macronutrient quality and composition are important determinants of energy balance and the gut microbiota. Here, we investigated how changes to protein quality (casein versus whey protein isolate; WPI) and the protein to carbohydrate (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44064635a7084f19552c4758e9557467
http://europepmc.org/articles/PMC3919831?pdf=render

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Saturation mutagenesis of lysine 12 leads to the identification of derivatives of nisin A with enhanced antimicrobial activity

Autor: Evelyn M. Molloy, Colin Hill, Paul D. Cotter, R. Paul Ross, Paula M. O’ Connor, Des Field

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 3, p e58530 (2013)

peer-reviewed It is becoming increasingly apparent that innovations from the “golden age” of antibiotics are becoming ineffective, resulting in a pressing need for novel therapeutics. The bacteriocin family of antimicrobial peptides has attracted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7438d6e383e3f21923594c079ea616
https://pubmed.ncbi.nlm.nih.gov/23505531

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