Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Paula M, Canas"'
Autor:
Ana P. Simões, Marina A. M. Portes, Cátia R. Lopes, Felipe Vanz, Vanessa S. Lourenço, Anna Pliássova, Ingride L. Gaspar, Henrique B. Silva, Ângelo R. Tomé, Paula M. Canas, Rui D. Prediger, Rodrigo A. Cunha
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Fear learning is essential to survival, but traumatic events may lead to abnormal fear consolidation and overgeneralization, triggering fear responses in safe environments, as occurs in post-traumatic stress disorder (PTSD). Adenosine A2A re
Externí odkaz:
https://doaj.org/article/3834a2837f16481986b09c5d0cbaafe9
Autor:
Ana Carla L. Nunes, Marta Carmo, Andrea Behrenswerth, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4903 (2024)
Adenosine A2A receptor (A2AR) antagonists are the leading nondopaminergic therapy to manage Parkinson’s disease (PD) since they afford both motor benefits and neuroprotection. PD begins with a synaptic dysfunction and damage in the striatum evolvin
Externí odkaz:
https://doaj.org/article/9fd4d223dd634e1eb1dfdbe7c500495b
Autor:
Cátia R. Lopes, António C. Silva, Henrique B. Silva, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha, João Pedro Lopes
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1173 (2023)
The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer’s disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the b
Externí odkaz:
https://doaj.org/article/9889209a01ac4ec1a0d7451a1a94d22a
Autor:
Cátia R. Lopes, Joana S. Silva, Joana Santos, Matilde S. Rodrigues, Daniela Madeira, Andreia Oliveira, Ana Moreira-de-Sá, Vanessa S. Lourenço, Francisco Q. Gonçalves, Henrique B. Silva, Ana Patrícia Simões, Anabela P. Rolo, Paula M. Canas, Ângelo R. Tomé, Carlos M. Palmeira, João Pedro Lopes, Rodrigo A. Cunha, Paula Agostinho, Samira G. Ferreira
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 6968 (2023)
Alzheimer’s disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old fe
Externí odkaz:
https://doaj.org/article/74eefc30c039410eb7b8b72a8ce3d869
Autor:
Cátia R. Lopes, Andreia Oliveira, Ingride Gaspar, Matilde S. Rodrigues, Joana Santos, Eszter Szabó, Henrique B. Silva, Ângelo R. Tomé, Paula M. Canas, Paula Agostinho, Rui A. Carvalho, Rodrigo A. Cunha, Ana Patrícia Simões, João Pedro Lopes, Samira G. Ferreira
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 106 (2023)
Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors a
Externí odkaz:
https://doaj.org/article/c1dfbb01209e4e63a8978f837859d8ba
Autor:
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105441- (2021)
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A
Externí odkaz:
https://doaj.org/article/218cea5ef5a84400aaea77837c4e90ac
Autor:
Ana Patrícia Simões, Francisco Q. Gonçalves, Daniel Rial, Samira G. Ferreira, João Pedro Lopes, Paula M. Canas, Rodrigo A. Cunha
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12826 (2022)
Adenosine A2A receptors (A2AR) control fear memory and the underlying processes of synaptic plasticity in the amygdala. In other brain regions, A2AR activation is ensured by ATP-derived extracellular adenosine formed by ecto-5′-nucleotidase or CD73
Externí odkaz:
https://doaj.org/article/bf67d92b1f7a47ef9716b399742bc61e
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Extracellular adenosine is produced with increased metabolic activity or stress, acting as a paracrine signal of cellular effort. Adenosine receptors are most abundant in the brain, where adenosine acts through inhibitory A1 receptors to decrease act
Externí odkaz:
https://doaj.org/article/761460cf0db84b22be41c8771fe5f39b
Autor:
Ana Moreira-de-Sá, Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Ângelo R. Tomé, Rodrigo A. Cunha, Paula M. Canas
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105137- (2020)
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of function of the maternally inherited Ube3a neuronal protein, whose main features comprise severe intellectual disabilities and motor impairments. Previous studies with the Ube3
Externí odkaz:
https://doaj.org/article/b59b852f614d4665b6515b9ec4f33605
Autor:
António C. Silva, Cristina Lemos, Francisco Q. Gonçalves, Anna V. Pliássova, Nuno J. Machado, Henrique B. Silva, Paula M. Canas, Rodrigo A. Cunha, João Pedro Lopes, Paula Agostinho
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 72-81 (2018)
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A2A receptors (A2AR) are mostly located in synapses controlling synaptic plasticity. The over-activation of adenosine A2A receptors (A2AR) causes memory deficits and th
Externí odkaz:
https://doaj.org/article/7eac53947721403c9a17b334ba8169ed