Zobrazeno 1 - 10
of 455
pro vyhledávání: '"Paula M, Alves"'
Autor:
Pedro Vicente, Joana I. Almeida, Inês E. Crespo, Nikolaus Virgolini, Inês A. Isidro, Maria Eréndira Calleja-Cervantes, Juan R. Rodriguez-Madoz, Felipe Prosper, Paula M. Alves, Margarida Serra
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Hepatocytes-like cells (HLC) derived from human induced pluripotent stem cells show great promise for cell-based liver therapies and disease modelling. However, their application is currently hindered by the low production yields of existing
Externí odkaz:
https://doaj.org/article/70c758a07bc245059b4c1832ecd92381
Autor:
Kiran Iqbal Masood, Shama Qaiser, Syed Hani Abidi, Erum Khan, Syed Faisal Mahmood, Areeba Hussain, Zara Ghous, Khekahsan Imtiaz, Natasha Ali, Muhammad Hasan, Haris Ali Memon, Maliha Yameen, Shiza Ali, Sadaf Baloch, Gulzar Lakhani, Paula M. Alves, Najeeha Talat Iqbal, Kumail Ahmed, Junaid Iqbal, Zulfiqar A. Bhutta, Rabia Hussain, Martin Rottenberg, J. Pedro Simas, Marc Veldhoen, Kulsoom Ghias, Zahra Hasan
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Protection against SARS-CoV-2 is mediated by humoral and T cell responses. Pakistan faced relatively low morbidity and mortality from COVID-19 through the pandemic. To examine the role of prior immunity in the population, we studi
Externí odkaz:
https://doaj.org/article/daab1b9127084bd1ae6c4561d555d5e2
Autor:
Catarina M. Gomes, Maria João Sebastião, Gabriela Silva, Filipa Moura, Daniel Simão, Patrícia Gomes-Alves, Paula M. Alves, Catarina Brito
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Engineered 3D models employing human induced pluripotent stem cell (hiPSC) derivatives have the potential to recapitulate the cell diversity and structure found in the human central nervous system (CNS). Therefore, these complex cellula
Externí odkaz:
https://doaj.org/article/0f7b8e5722b64a128671efc652b70aa4
Autor:
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, António Roldão, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The first exposure to influenza is presumed to shape the B-cell antibody repertoire, leading to preferential enhancement of the initially formed responses during subsequent exposure to viral variants. Here, we investigated whether this principle rema
Externí odkaz:
https://doaj.org/article/fe0da1bcfd6c40f6beed32ab73a26fdd
Autor:
Marco Silvano, Nikolaus Virgolini, Ricardo Correia, Colin Clarke, Inês A. Isidro, Paula M. Alves, António Roldão
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
The insect cell-baculovirus expression vector system (IC-BEVS) has been widely used to produce recombinant protein at high titers, including complex virus-like particles (VPLs). However, cell-to-cell variability upon infection is yet one of the least
Externí odkaz:
https://doaj.org/article/f37779f98da846e497732d9cc4cb4ee6
Autor:
Akash Khandelwal, Francisca Arez, Paula M. Alves, Lassina Badolo, Catarina Brito, Christoph Fischli, Diana Fontinha, Claude Oeuvray, Miguel Prudêncio, Matthias Rottmann, Justin Wilkins, Özkan Yalkinoglu, Wilhelmina M. Bagchus, Thomas Spangenberg
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibitor
Externí odkaz:
https://doaj.org/article/1a184acca8e44dcf9fd53edb5f8e0845
Autor:
Stefanie K. Menzies, Raquel Arinto-Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso, Camille Abada, Thomas Crasset, Fabien Durbesson, Rebecca J. Edge, Priscila El-Kazzi, Sophie Hall, Damien Redureau, Richard Stenner, Johara Boldrini-França, Huan Sun, António Roldão, Paula M. Alves, Robert A. Harrison, Renaud Vincentelli, Imre Berger, Loïc Quinton, Nicholas R. Casewell, Christiane Schaffitzel
Publikováno v:
Toxins, Vol 15, Iss 12, p 673 (2023)
Snakebite envenoming can be a life-threatening medical emergency that requires prompt medical intervention to neutralise the effects of venom toxins. Each year up to 138,000 people die from snakebites and threefold more victims suffer life-altering d
Externí odkaz:
https://doaj.org/article/ec9c5b6609d8440596a5de2726789690
Autor:
João Faro-Viana, Marie-Louise Bergman, Lígia A. Gonçalves, Nádia Duarte, Teresa P. Coutinho, Patrícia C. Borges, Christian Diwo, Rute Castro, Paula Matoso, Vanessa Malheiro, Ana Brennand, Lindsay Kosack, Onome Akpogheneta, João M. Figueira, Conceição Cardoso, Ana M. Casaca, Paula M. Alves, Telmo Nunes, Carlos Penha-Gonçalves, Jocelyne Demengeot
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Here, in a longitudinal cohort of 1245 hospital care workers and 146 nursing home residents, the authors find that a large inter-individual variation in anti-spike antibody levels after one dose of BNT162b2mRNA vaccine is partially explained by age,
Externí odkaz:
https://doaj.org/article/cf463c30cb5c4ebca7bfc8987cfe0b96
Autor:
Miguel F. Tenreiro, Henrique V. Almeida, Tomás Calmeiro, Elvira Fortunato, Lino Ferreira, Paula M. Alves, Margarida Serra
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The extracellular matrix (ECM) of engineered human cardiac tissues corresponds to simplistic biomaterials that allow tissue assembly, or animal derived off-the-shelf non-cardiac specific matrices. Decellularized ECM from human cardiac tissue
Externí odkaz:
https://doaj.org/article/80f5207bcc144240aedefa1844a6dd8d
Autor:
João P. Mendes, Bárbara Fernandes, Earl Pineda, Shashi Kudugunti, Mike Bransby, René Gantier, Cristina Peixoto, Paula M. Alves, António Roldão, Ricardo J. S. Silva
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Adeno-associated viruses (AAVs) demand for clinical trials and approved therapeutic applications is increasing due to this vector’s overall success and potential. The high doses associated with administration strategies challenges bioprocess engine
Externí odkaz:
https://doaj.org/article/eb6e26dfbfb0422c8be339d3785d3d01