Výsledky vyhledávání - "Paula Lee Tao"

Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning

Autor: David Cain, Milady R. Niñonuevo, Jordan J Baker, Dana McDaniel, Yuting Huang, Judith Zhu-Shimoni, Hongbin Liu, Paula Lee Tao, Charlene Li

Publikováno v: Analytical Chemistry. 91:965-976

Bispecific antibodies are regarded as the next generation of therapeutic modalities as they can simultaneously bind multiple targets, increasing the efficacy of treatments for several diseases and opening up previously unattainable treatment designs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3510a0a81863367542f847a72077362
https://doi.org/10.1021/acs.analchem.8b04071

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Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody

Autor: Paula Lee Tao, Aaron T. Wecksler, Alavattam Sreedhara, Galahad Deperalta, Jian Yin, Bruce Kabakoff

Publikováno v: Molecular pharmaceutics. 15(4)

Photostability conditions as prescribed by ICH guidelines induced highly reduction-resistant scrambled disulfides that contribute to the population of apparent nonreducible aggregates in an IgG1 mAb. Photoinduced cross-linked species were isolated un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeba7e1e7ac037d0ed672b65d27a8d1
https://pubmed.ncbi.nlm.nih.gov/29502420

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