Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Paula L Hedley"'
Autor:
Victoria E de Knegt, Paula L Hedley, Gitte Hedermann, Casper Wilstrup, Marie Bækvad-Hansen, Ida N Thagaard, Henrik Hjalgrim, Jørgen Kanters, Mads Melbye, David M Hougaard, Anders Hviid, Lone Krebs, Morten Breindahl, Ulrik Lausten-Thomsen, Michael Christiansen
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283909 (2023)
In Denmark, a nationwide COVID-19 lockdown was implemented on March 12, 2020 and eased on April 14, 2020. The COVID-19 lockdown featured reduced prevalence of extremely preterm or extremely low birthweight births. This study aims to explore the impac
Externí odkaz:
https://doaj.org/article/49c3fe60a79e485b806b2bd6cb4c9eda
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0272465 (2023)
IntroductionPre-eclampsia (PE) is a leading cause of perinatal morbidity and mortality worldwide. Low-dose aspirin can prevent PE in high risk pregnancies if started early. However, despite intense research into the area, early pregnancy screening fo
Externí odkaz:
https://doaj.org/article/8ea8035dbef14457b13c404a07701765
Autor:
Gitte Hedermann, Paula L Hedley, Ida N Thagaard, Lone Krebs, Charlotte Kvist Ekelund, Thorkild I A Sørensen, Michael Christiansen
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252343 (2021)
BackgroundCongenital heart defects (CHDs) are the most common congenital malformations. The aetiology of CHDs is complex. Large cohort studies and systematic reviews and meta-analyses based on these have reported an association between higher risk of
Externí odkaz:
https://doaj.org/article/6eaf68dfdc08462a8f7badf0217b7e11
Autor:
Christian M Hagen, Vanessa F Gonçalves, Paula L Hedley, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Christine S Hansen, Jørgen K Kanters, Jimmi Nielsen, Ole Mors, Alfonso B Demur, Thomas D Als, Merete Nordentoft, Anders Børglum, Preben B Mortensen, James Kennedy, Thomas M Werge, David M Hougaard, Michael Christiansen
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208828 (2018)
Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiat
Externí odkaz:
https://doaj.org/article/7b7ccbdae1364f90b1f8698727cce3e6
Autor:
Jonas Bybjerg-Grauholm, Christian M Hagen, Vanessa F Gonçalves, Marie Bækvad-Hansen, Christine S Hansen, Paula L Hedley, Jørgen K Kanters, Jimmi Nielsen, Michael Theisen, Ole Mors, James Kennedy, Thomas D Als, Alfonso B Demur, Merete Nordentoft, Anders Børglum, Preben B Mortensen, Thomas M Werge, David M Hougaard, Michael Christiansen
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208829 (2018)
Mitochondrial DNA (mtDNA) haplogroups (hgs) are evolutionarily conserved sets of mtDNA SNP-haplotypes with characteristic geographical distribution. Associations of hgs with disease and physiological characteristics have been reported, but have frequ
Externí odkaz:
https://doaj.org/article/9d4ecedb89b043e085e49ee484ce1525
Autor:
Christian M Hagen, Frederik H Aidt, Ole Havndrup, Paula L Hedley, Morten K Jensen, Jørgen K Kanters, Tam T Pham, Henning Bundgaard, Michael Christiansen
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124540 (2015)
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease primarily caused by mutations in genes coding for sarcomeric proteins. A molecular-genetic etiology can be established in ~60% of cases. Evolutionarily conserved mitochondrial DNA (mtDNA)
Externí odkaz:
https://doaj.org/article/347616c48d174892929bd3afcbb890c8
Autor:
Christian M Hagen, Frederik H Aidt, Paula L Hedley, Morten K Jensen, Ole Havndrup, Jørgen K Kanters, Johanna C Moolman-Smook, Severin O Larsen, Henning Bundgaard, Michael Christiansen
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71904 (2013)
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes coding for proteins involved in sarcomere function. The disease is associated with mitochondrial dysfunction. Evolutionarily developed variation in mitochondrial DNA
Externí odkaz:
https://doaj.org/article/4388564e67bf4d619bb8318a47927675
Autor:
Bright Adu, Daniel Dodoo, Selorme Adukpo, Paula L Hedley, Fareed K N Arthur, Thomas A Gerds, Severin O Larsen, Michael Christiansen, Michael Theisen
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46197 (2012)
Plasmodium falciparum malaria kills nearly a million people annually. Over 90% of these deaths occur in children under five years of age in sub-Saharan Africa. A neutrophil mediated mechanism, the antibody dependent respiratory burst (ADRB), was rece
Externí odkaz:
https://doaj.org/article/baadd38e913a4a89a47adbcd7926eb9d
Autor:
Bright Adu, Daniel Dodoo, Selorme Adukpo, Ben A Gyan, Paula L Hedley, Bamenla Goka, George O Adjei, Severin O Larsen, Michael Christiansen, Michael Theisen
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29465 (2011)
BACKGROUND: Cerebral malaria (CM) is the most severe outcome of Plasmodium falciparum infection and a major cause of death in children from 2 to 4 years of age. A hospital based study in Ghana showed that P. falciparum induces eosinophilia and found
Externí odkaz:
https://doaj.org/article/7c4c1486f9ea40b4968454aa740149d5
Autor:
Kristina Wendelboe Olsen, Paula L. Hedley, Christian M. Hagen, Line Rode, Sophie Placing, Karen R Wøjdemann, Anne-Cathrine Shalmi, Karin Sundberg, Anne Nørremølle, Ann Tabor, Joanna L. Elson, Michael Christiansen
ObjectiveTo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.MethodsThis retrospective study haplotyped 235 control and 78 preeclam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565ceb44c913c5372151d447e97ae61e
https://doi.org/10.1101/2023.05.22.23290334
https://doi.org/10.1101/2023.05.22.23290334
