Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Paula L, Hoffman"'
Autor:
Boris Tabakoff, Paula L. Hoffman
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The translation of extracellular signals to intracellular responses involves a number of signal transduction molecules. A major component of this signal transducing function is adenylyl cyclase, which produces the intracellular “second messenger,
Externí odkaz:
https://doaj.org/article/1e399e0ea179475aba14bf965332dac5
Autor:
Ryan Lusk, Paula L. Hoffman, Spencer Mahaffey, Samuel Rosean, Harry Smith, Jan Silhavy, Michal Pravenec, Boris Tabakoff, Laura M. Saba
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation. The
Externí odkaz:
https://doaj.org/article/75e02fa602fb446085e3faeeaa0486aa
Autor:
Cecilia M. Borghese, Melissa Herman, Lawrence D. Snell, Keri J. Lawrence, Hyun-Young Lee, Donald S. Backos, Lauren A. Vanderlinden, R. Adron Harris, Marisa Roberto, Paula L. Hoffman, Boris Tabakoff
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABAA)
Externí odkaz:
https://doaj.org/article/deb9d0e8116a4679aa8f5c369a838e42
Autor:
Paula L. Hoffman, Michal Pravenec, Laura Saba, Spencer Mahaffey, Jennifer Mahaffey, Boris Tabakoff, Lauren A. Vanderlinden
BackgroundCardiac hypertrophy can be considered a maladaptive response which in many cases results in heart failure and sudden death. Genetic predisposition to cardiac hypertrophy is ill-defined, but current research has given credence to a role of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbcb54b61d7982b5e1861020298e6bc2
https://doi.org/10.21203/rs.3.rs-766340/v1
https://doi.org/10.21203/rs.3.rs-766340/v1
Autor:
Dorothy J. Yamamoto, Jody Tanabe, Mark S. Brown, Ellen L. Burnham, Brianne Sutton, Deborah H. Glueck, Paula L. Hoffman, Boris Tabakoff
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND Acute alcohol produces effects on cerebral metabolism and blood flow. Alcohol is converted to acetate, which serves as a source of energy for the brain and is an agonist at G protein-coupled receptors distributed in different cell types in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f376ee545a04385cb65bb9a629c8f47f
https://doi.org/10.1111/acer.14173
https://doi.org/10.1111/acer.14173
Autor:
Igor Ponomarev, Robert W. Williams, Brent R. Kisby, Susan E. Bergeson, Kerrie H. Lodowski, Denesa R. Lockwood, Laura Saba, Aashlesha Walchale, Tamara J. Phillips, Robert Hitzemann, Julie A. Owen, Angela R. Ozburn, Deborah A. Finn, Andrew Holmes, Michelle M McManus, Jason A. Bubier, Boris Tabakoff, Praneetha Panthagani, Elissa J. Chesler, Ari E. Berman, Matthew Hein, Paula L. Hoffman
Publikováno v:
Biol Psychiatry
There is compelling evidence that sex and gender have crucial roles in excessive alcohol (ethanol) consumption. Here we review some of the data from the perspective of brain transcriptional differences between males and females, focusing on rodent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2848114b1368aa82413c8310e065f6
https://pubmed.ncbi.nlm.nih.gov/34274109
https://pubmed.ncbi.nlm.nih.gov/34274109
Autor:
Lauren A Vanderlinden, Laura M Saba, Katerina Kechris, Michael F Miles, Paula L Hoffman, Boris Tabakoff
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68878 (2013)
To identify brain transcriptional networks that may predispose an animal to consume alcohol, we used weighted gene coexpression network analysis (WGCNA). Candidate coexpression modules are those with an eigengene expression level that correlates sign
Externí odkaz:
https://doaj.org/article/7fdaa945beb84eab8915cd650ed712c8
Autor:
Paula L. Hoffman, Sarath Chandra Janga, Boris Tabakoff, Swapna Vidhur Daulatabad, Spencer Mahaffey, Gregg E. Homanics, Laura Saba
Publikováno v:
Genes, Brain, and Behavior
LncRNAs are important regulators of quantitative and qualitative features of the transcriptome. We have used QTL and other statistical analyses to identify a gene coexpression module associated with alcohol consumption. The “hub gene” of this mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6774deee4f6c3a1423e8ffa5348f9b73
https://doi.org/10.1111/gbb.12698
https://doi.org/10.1111/gbb.12698
Autor:
Jennifer L. Groebner, Laura E. Nagy, Helmut K. Seitz, Lawrence Cohen, Afifiyan Nikko, Vitocruz Edward, Samuel W. French, Sebastian Mueller, Kylie K. Harrall, Pamela L. Tuma, Manuela G. Neuman, Opris Mihai, Laura Saba, Heidekazu Tsukamoto, Mendoza Alejandro, Michael Fasullo, Paula L. Hoffman, Boris Tabakoff, Jia Yue, Stephen Malnick, French A. Barbara, Tillman Brittany, Bernd Schnabl
Publikováno v:
Biomedicines
Biomedicines, vol 8, iss 3
Biomedicines, Vol 8, Iss 3, p 63 (2020)
Biomedicines, vol 8, iss 3
Biomedicines, Vol 8, Iss 3, p 63 (2020)
The following review article presents clinical and experimental features of alcohol-induced liver disease (ALD). Basic aspects of alcohol metabolism leading to the development of liver hepatotoxicity are discussed. ALD includes fatty liver, acute alc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb24183bfae96be240540435639e6b52
http://europepmc.org/articles/PMC7148515
http://europepmc.org/articles/PMC7148515
Autor:
Boris Tabakoff, Paula L. Hoffman
Publikováno v:
Journal of psychiatry and brain science
We report on the ongoing project "A Novel Therapeutic to Ameliorate Chronic Pain and Reduce Opiate Use." Over 100 million adults in the U.S. suffer from intermittent or constant chronic pain, and chronic pain affects at least 10% of the world's popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19107c99735e49939e131e6284f0da21
https://doi.org/10.20900/jpbs.20200022
https://doi.org/10.20900/jpbs.20200022